☆ 4.6 Review

Autoimmune pre-disease

AUTOIMMUNITY REVIEWS (2023)

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Review Clinical Neurology

Assessment of the impact of shift work on thyroid disorders: a systematic review and meta-analysis

Jingyi Luo et al.

Summary: This study conducted a meta-analysis to summarize the impact of shift work on thyroid disorders. The results showed that shift work may lead to abnormal TSH and FT4 levels, but had no clear effect on the risk of positive thyroid autoantibodies.

SLEEP AND BREATHING (2023)

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Article Rehabilitation

Effects of 12-week aerobic exercise on patient-reported outcomes in women with systemic lupus erythematosus

Blanca Gavilan-Carrera et al.

Summary: This study found that 12 weeks of aerobic exercise may improve fatigue in women with systemic lupus erythematosus (SLE), although it did not have significant effects on other patient-reported outcomes (PROs). The improvements in cardiorespiratory fitness seemed to mediate the effects of exercise on reducing fatigue.

DISABILITY AND REHABILITATION (2022)

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Review Immunology

MHC haplotype and B cell autoimmunity: Correlation with pathogenic IgG autoantibody subclasses and Fc glycosylation patterns

Larissa Nogueira Almeida et al.

Summary: MHC haplotypes play a crucial role in the development of autoimmune diseases, modulating autoreactive B cell responses and facilitating the production of pathogenic IgG autoantibodies with reduced pathogenicity.

EUROPEAN JOURNAL OF IMMUNOLOGY (2022)

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Editorial Material Pharmacology & Pharmacy

Longitudinal Analysis Suggests Epstein--Barr as Cause of Multiple Sclerosis

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Review Immunology

Recent advances in understanding the genetic basis of systemic lupus erythematosus

Eunji Ha et al.

Summary: Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease with a high heritability of up to 66%, with most risk variants residing in non-coding regions. Recent studies have identified dozens of new SLE loci and integrated GWAS signals with other biological resources in genetic associations. The research also explores genetic risk scores for SLE and their associations with clinical features, as well as variant-driven pathogenetic functions and future challenges in genetic studies on SLE.

SEMINARS IN IMMUNOPATHOLOGY (2022)

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Review Respiratory System

Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease

Sebastian T. Lugg et al.

Summary: Smoking disrupts the function of alveolar macrophages, increasing the risk of acute lung injury and pulmonary infection.

THORAX (2022)

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Review Dermatology

The global incidence of bullous pemphigoid: a systematic review and meta-analysis

M. S. M. Persson et al.

Summary: The global incidence of Bullous Pemphigoid is generally low but appears to be increasing over time, with higher rates in Europe and Asia. There is significant heterogeneity in the pooled estimates, indicating that the burden of disease may be underestimated.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Allergy

Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings

Maria Sokolova et al.

Summary: Autoantibodies such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA) are key markers of rheumatoid arthritis (RA) and can impact disease course and progression. The identification of new autoantibodies and advancements in diagnostic techniques have led to a decrease in the seronegative patient population. Autoantibodies not only play a role in the pathogenesis of RA but also directly influence disease progression and radiographic outcomes.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

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Article Rheumatology

Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching

Xiaoyang Yue et al.

Summary: This study successfully induced AT1R antibodies using an immunization strategy and found that these antibodies activate the AT1R, leading to inflammation and fibrosis. These findings suggest that AT1R antibodies could be potential targets for therapies of systemic sclerosis (SSc) and other AT1R antibody-related diseases.

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Article Biochemistry & Molecular Biology

Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation

Stephen F. Marino et al.

Summary: CD177 is a receptor specific to neutrophils, presenting the PR3 autoantigen on their surface. The CD177:PR3 membrane complex plays a crucial role in the severity of PR3-ANCA diseases. High-affinity anti-CD177 monoclonal antibodies have been generated to interfere with PR3 binding to CD177 and reduce neutrophil activation.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Article Dermatology

Clinical features of dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid in Japan: A nationwide retrospective observational study

Seiko Sugiyama et al.

Summary: This retrospective study investigated the incidence, clinical presentation, and clinical course of DPP-4i-associated bullous pemphigoid (BP) using data from a nationwide registry for BP in Japan. The results showed that DPP-4i-BP was more common in males and non-inflammatory BP was more frequently observed in DPP-4i-BP cases. Some patients achieved spontaneous remission after discontinuing DPP-4i.

JOURNAL OF DERMATOLOGY (2022)

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Article Multidisciplinary Sciences

Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells

Bandik Foeh et al.

Summary: The microbial metabolite butyrate promotes the differentiation of IgM(+) plasma cells and their expression of IL-10. HDAC3 inhibition may be involved in the underlying pathway for both plasma cell differentiation and IL-10 expression, while reduced mitochondrial superoxide levels are crucial only for plasma cell differentiation.

PLOS ONE (2022)

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Review Rheumatology

Patient Experiences of Systemic Lupus Erythematosus: Findings From a Systematic Review, Meta-Summary, and Meta-Synthesis

Valentina Petrocchi et al.

Summary: Qualitative studies on the experience of patients with systemic lupus erythematosus have shown that SLE negatively impacts patients' daily lives, with fatigue and pain as the most frequent symptoms. The experience of living with SLE includes emotional fluctuations, striving for a normal life, listening to the body's limitations, reflecting on life projects, and coping with future uncertainties.

ARTHRITIS CARE & RESEARCH (2022)

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Review Immunology

Perspectives of at-Risk Individuals on Preventive Intervention for Rheumatoid Arthritis: A Mini Review

Marie Falahee et al.

Summary: There has been significant research on understanding the biological mechanisms of rheumatoid arthritis (RA) and the state of autoimmunity that precedes symptom development. This has sparked interest in identifying at-risk groups and exploring preventive interventions. Immunomodulatory agents and cellular therapies are being investigated for their potential to delay or prevent RA and other chronic autoimmune diseases. However, there are challenges in recruiting at-risk individuals for prevention trials and understanding their preferences for benefits and risks. This review aims to summarize current knowledge and make recommendations for further research on RA prevention.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Understanding the Concept of Pre-Clinical Autoimmunity: Prediction and Prevention of Systemic Lupus Erythematosus: Identifying Risk Factors and Developing Strategies Against Disease Development

May Y. Choi et al.

Summary: There is evidence that patients with systemic lupus erythematosus (SLE) have markers of inflammation and autoimmunity before the diagnosis. Understanding the preclinical phase of SLE can help identify at-risk patients and implement preventative strategies.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid

Yuichiro Iwamoto et al.

Summary: DPP-4 inhibitors are closely associated with bullous pemphigoid (BP) and may lead to disruption of immune tolerance. Checking autoimmune antibodies may be important in DPP-4i-related BP, even when symptoms improve.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Anaphylatoxins spark the flame in early autoimmunity

Jovan Schanzenbacher et al.

Summary: The complement system is an important part of the innate immune system with a complex role in autoimmunity. Dysregulation of the complement system has been associated with the development of autoimmune disorders. Anaphylatoxins, such as C3a and C5a, play a crucial role in the inflammatory response during autoimmunity and regulate both innate and adaptive immune responses.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Use of gliptins reduces levels of SDF-1/CXCL12 in bullous pemphigoid and type 2 diabetes, but does not increase autoantibodies against BP180 in diabetic patients

Antti Natynki et al.

Summary: The use of DPP4 inhibitors, such as gliptins, in patients with type 2 diabetes is associated with an increased risk of bullous pemphigoid (BP). This study investigated the presence of autoantibodies against the major BP autoantigen BP180 in patients with or without gliptin medication. The results showed that the presence of autoantibodies against BP180 was common in both groups, and the use of gliptins did not affect the seropositivity.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Immunogenic cell death as driver of autoimmunity in granulomatosis with polyangiitis

Christoph Brieske et al.

Summary: Cell death and dysregulated clearance of dead cells play crucial roles in chronic inflammatory processes and autoimmune diseases. This review discusses how regulated cell death and the release of damage-associated molecular patterns (DAMP) contribute to the granulomatous tissue inflammation and autoimmune responses in granulomatosis with polyangiitis (GPA).

FRONTIERS IN IMMUNOLOGY (2022)

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Article Rheumatology

Baseline IgG-Fc N-glycosylation profile is associated with long-term outcome in a cohort of early inflammatory arthritis patients

Thomas Senard et al.

Summary: This study assessed the association between IgG glycoforms and disease prognosis in early inflammatory arthritis patients. The results showed a significant association between high levels of IgG2/3 Fc galactosylation and favorable outcome after 2 years of treatment. The study suggests that using IgG glycosylation levels as a prognostic marker in early arthritis can overcome the limitations of current prognostic tools.

ARTHRITIS RESEARCH & THERAPY (2022)

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Article Rheumatology

Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada

Naizhuo Zhao et al.

Summary: This study aimed to estimate the associations between fine particulate matter and ozone with the onset of systemic autoimmune rheumatic diseases. The results showed a correlation between PM2.5 and SARDs incidence, but no clear relationship with ozone was found. Additional studies are needed to better understand the interplays between air pollutants and rheumatic diseases.

ARTHRITIS RESEARCH & THERAPY (2022)

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Article Multidisciplinary Sciences

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Kjetil Bjornevik et al.

Summary: This study suggests that multiple sclerosis may be caused by Epstein-Barr virus, with no direct association with other viral infections. These findings provide clues to the primary cause of MS.

SCIENCE (2022)

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Article Dermatology

Incidence, prevalence and mortality of bullous pemphigoid in England 1998-2017: a population-based cohort study

M. S. M. Persson et al.

Summary: The study found an increase in the incidence rate of BP in England, especially among elderly men. The burden of disease in the elderly population is substantial, and mortality is significantly higher in the first 2 years after a BP diagnosis.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Rheumatology

Obesity Progression Between Young Adulthood and Midlife and Incident Arthritis: A Retrospective Cohort Study of US Adults

Kaitlyn M. Berry et al.

Summary: Weight loss from young adulthood to midlife is associated with a substantially reduced risk of developing arthritis, emphasizing the importance of expanding obesity treatment and prevention to reduce the burden of arthritis.

ARTHRITIS CARE & RESEARCH (2021)

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Article Allergy

Enriched blood IgG sialylation attenuates IgG-mediated and IgG-controlled-IgE-mediated allergic reactions

Janina Petry et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Dermatology

IgG Fc N-Glycosylation Translates MHCII Haplotype into Autoimmune Skin Disease

Ann-Katrin Clauder et al.

Summary: This study found that in a mouse model of epidermolysis bullosa acquisita, mice with the susceptible H2s haplotype showed increased numbers of autoreactive CD4(+) T cells and elevated production of proinflammatory factors, along with a higher frequency of IgG autoantibodies with specific glycan structures. These results reveal that susceptibility to autoimmune diseases associated with major histocompatibility complex II acuminates in a proinflammatory IgG glycosylation pattern.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Dermatology

More Severe Erosive Phenotype Despite Lower Circulating Autoantibody Levels in Dipeptidyl Peptidase-4 Inhibitor (DPP4i)-Associated Bullous Pemphigoid: A Retrospective Cohort Study

Sascha Stander et al.

Summary: Patients with DPP4i-associated BP exhibit a more severe blistering and erosive presentation despite lower levels of typically pathogenic antibodies.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

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Article Rheumatology

Abdominal Obesity in Comparison with General Obesity and Risk of Developing Rheumatoid Arthritis in Women

Nathalie E. Marchand et al.

Summary: The study found that abdominal obesity increased the risk of developing rheumatoid arthritis, particularly for seropositive RA, among young and middle-aged women. However, abdominal obesity did not independently contribute to RA risk beyond general obesity.

JOURNAL OF RHEUMATOLOGY (2021)

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Article Rheumatology

Is exposure to environmental factors associated with a characteristic clinical and laboratory profile in systemic sclerosis? A retrospective analysis

Lisbeth A. Aguila et al.

Summary: This study showed that systemic sclerosis patients with previous exposure to environmental factors may have specific clinical characteristics, mainly a higher frequency of myopathy, more severe interstitial lung disease, particularly in male and African-Brazilian patients, associated with a lower frequency of ANA positivity.

RHEUMATOLOGY INTERNATIONAL (2021)

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Article Immunology

Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis

Francesca Romana Rizzo et al.

Summary: Exercise is recommended as a beneficial supportive therapy for people with MS, improving motor disability and pathological features. Chronic voluntary exercise has positive effects on motor disability, cognition, and hippocampal damage in an animal model of MS, by reducing inflammation, promoting synaptic plasticity, and protecting neurons. Overall, regular exercise improves cognitive function and brain pathology in EAE/MS.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Dermatology

Incidence of pemphigoid diseases in Northern Germany in 2016-first data from the Schleswig-Holstein Registry of Autoimmune Bullous Diseases

N. van Beek et al.

Summary: The study prospectively analyzed the incidence of PD in a well-defined geographical area in Northern Germany, finding the highest incidence among PD patients for bullous pemphigoid. The incidence of bullous pemphigoid is significantly increased compared to previous reports, and regional differences were also observed. Further studies are needed to clarify these findings.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Article Immunology

Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes

Yuko Okamato et al.

Summary: The presence of anti-citrullinated protein/peptide antibodies (ACPA) and epitope spreading is unique to rheumatoid arthritis (RA). Researchers found significantly elevated H3 citrullination in specific immune cells in subjects at risk for future development of RA as well as in early RA patients. These immune cells with elevated H3 citrullination display dysregulated cytokine production and formation of monocyte extracellular traps (METs), likely contributing to the development and perpetuation of inflammation in RA.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Medicine, General & Internal

Avacopan for the Treatment of ANCA-Associated Vasculitis

David R. W. Jayne et al.

Summary: In this study, the C5a receptor inhibitor avacopan was found to be noninferior to prednisone taper in achieving remission at week 26, but superior in achieving sustained remission at week 52 in patients with ANCA-associated vasculitis. All patients received cyclophosphamide or rituximab. The safety and clinical effects of avacopan beyond 52 weeks were not addressed in the trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Multidisciplinary Sciences

Association between physical activity and changes in intestinal microbiota composition: A systematic review

Viviana Aya et al.

Summary: This review summarizes the results of human studies comparing the microbiome of healthy individuals with different physical activity amounts. The findings suggest that there are significant variations in diversity indexes and relative abundance of certain bacteria in the gut microbiota of active individuals in longitudinal studies. Further research incorporating diverse methods to evaluate other aspects related to active lifestyles is recommended.

PLOS ONE (2021)

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Article Rheumatology

The Burden of Systemic Lupus Erythematosus in Germany: Incidence, Prevalence, and Healthcare Resource Utilization

Andreas Schwarting et al.

Summary: The study found that the incidence of SLE in Germany increased by 1.4 times over 5 years. Patients with SLE have higher healthcare costs, and costs increase with baseline severity. Early and effective treatments may delay disease progression and reduce the burden of SLE.

RHEUMATOLOGY AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

The Effects of Vitamin D on Immune System and Inflammatory Diseases

Tomoka Ao et al.

Summary: Vitamin D plays a crucial role in immune cells and has anti-inflammatory effects. Deficiency in vitamin D is associated with infectious diseases and autoimmune diseases, though its impact on treatment and prevention remains controversial.

BIOMOLECULES (2021)

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Letter Genetics & Heredity

Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA105:05 and-DRB107:01, in Germans

Christian Schwarm et al.

Summary: Bullous pemphigoid (BP) is characterized by autoimmunity against certain proteins, and the strongest association in Germans was found in the HLA loci HLA-DQA1*05:05 and HLA-DRB1*07:01. Further research with larger sample sizes and integrating multiple pathogenic factors is planned.

ORPHANET JOURNAL OF RARE DISEASES (2021)

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Article Toxicology

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

Victor Yuji Yariwake et al.

Summary: This study found that exposure to fine particulate matter air pollution exacerbates some SLE manifestations in lupus-prone mice, highlighting the need to reduce air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.

PARTICLE AND FIBRE TOXICOLOGY (2021)

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Review Immunology

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases

Hanna Grasshoff et al.

Summary: Regulatory T cells (Treg) are crucial for maintaining peripheral tolerance and controlling inflammation and autoimmunity, with the cytokine interleukin-2 (IL-2) playing a key role in their growth and survival. Many autoimmune and rheumatic diseases show disruptions in Treg biology, leading to an imbalance between protective and pathogenic immune cells. Low-dose IL-2 therapy aims to restore physiological balance by compensating for IL-2 deficiency and strengthening the Treg population to counteract inflammation effectively.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Autoantibodies in Rheumatoid Arthritis - Laboratory and Clinical Perspectives

Johan Ronnelid et al.

Summary: Measurement of autoantibodies like RF and ACPA is crucial in the diagnosis and treatment of RA, but lack of harmonization between different commercial tests poses a challenge. It is recommended that all RF and ACPA tests should have a diagnostic specificity of 98-99%, and the introduction of test result-specific likelihood ratios can provide more precise information for clinical decision-making. Detection of autoantibodies can also be used to predict future arthritis development and prognosis in at-risk patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Rheumatology

A comprehensive framework for navigating patient care in systemic sclerosis: A global response to the need for improving the practice of diagnostic and preventive strategies in SSc

Lesley Ann Saketkoo et al.

Summary: Systemic sclerosis (SSc) is the most lethal rheumatologic condition, often leading to death from complications like pulmonary fibrosis and pulmonary hypertension. Early detection and treatment are crucial in preventing irreversible organ damage.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Granulomatous Inflammation in ANCA-Associated Vasculitis

Antje Mueller et al.

Summary: ANCA-associated vasculitis (AAV) includes GPA, MPA, and EGPA, with GPA characterized by granulomatous inflammation in the respiratory tract. The mechanisms underlying granulomatous inflammation in GPA are not fully understood, but may involve various molecules and cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

New-onset IgG autoantibodies in hospitalized patients with COVID-19

Sarah Esther Chang et al.

Summary: In hospitalized COVID-19 patients, approximately 50% have detectable autoantibodies primarily targeting autoantigens associated with rare disorders. Additionally, a subset of autoantibodies develop de novo following SARS-CoV-2 infection.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice

Xiaoyang Yue et al.

Summary: This study highlights the crucial role of B cells and sustained autoimmunity in the pathogenesis of SSc, demonstrated through a humanized mouse model. It provides a powerful tool for studying interstitial lung disease and other disease manifestations such as myositis and interstitial nephritis.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Allergy

Presence of IgE Autoantibodies Against Eosinophil Peroxidase and Eosinophil Cationic Protein in Severe Chronic Spontaneous Urticaria and Atopic Dermatitis

Jorge Sanchez et al.

Summary: The study found that IgE responses against eosinophil proteins may contribute to chronic inflammation in patients with atopic dermatitis and chronic spontaneous urticaria. Cross-reactivity between EPX and TPO could explain thyroid problems in CSU patients.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2021)

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Article Rheumatology

Atorvastatin is unlikely to prevent rheumatoid arthritis in high risk individuals: results from the prematurely stopped STAtins to Prevent Rheumatoid Arthritis (STAPRA) trial

Laurette van Boheemen et al.

Summary: This trial investigated the preventive effect of atorvastatin on arthritis development in high-risk individuals, but was prematurely stopped due to a low inclusion rate mainly caused by unwillingness to participate. While a protective effect of atorvastatin on arthritis development was not demonstrated in this small group, further research is needed to address barriers to participation in prevention trials.

RMD OPEN (2021)

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Review Rheumatology

Current view on the pathogenic role of anti-citrullinated protein antibodies in rheumatoid arthritis

Anca Catrina et al.

Summary: ACPA may play a crucial role in the pathogenesis of RA, affecting the genetic and environmental risks in patients, leading to joint pain and bone loss. Research has shown that ACPAs can impact various cells, potentially triggering pathogenic pathways through multiple mechanisms.

RMD OPEN (2021)

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Review Allergy

Pro-inflammatory immunological effects of adipose tissue and risk of food allergy in obesity: Focus on immunological mechanisms

X. Guo et al.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2020)

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Article Dermatology

BP180-specific IgG is associated with skin adverse events, therapy response, and overall survival in non-small cell lung cancer patients treated with checkpoint inhibitors

Omar Hasan Ali et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Rheumatology

Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population

Toshihiro Kishikawa et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Letter Dermatology

Assessment of healthcare costs for patients with pemphigus and bullous pemphigoid in an academic centre in Germany

S. Staender et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

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Article Rheumatology

Benefits of exercise in patients with rheumatoid arthritis: a randomized controlled trial of a patient-specific exercise programme

Maha Azeez et al.

CLINICAL RHEUMATOLOGY (2020)

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Review Biochemistry & Molecular Biology

Air pollution and its effects on the immune system

Drew A. Glencross et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Review Rheumatology

Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era

Ping-Hsuan Hsieh et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Immunology

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis

Christina Gerstner et al.

BMC IMMUNOLOGY (2020)

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Review Clinical Neurology

The impact of physical exercise on the fatigue symptoms in patients with multiple sclerosis: a systematic review and meta-analysis

Nazanin Razazian et al.

BMC NEUROLOGY (2020)

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Article Cell & Tissue Engineering

Positive transcriptional response on inflammation and joint remodelling influenced by physical exercise in proteoglycan-induced arthritis: An animal study

S. A. Gonzalez-Chavez et al.

BONE & JOINT RESEARCH (2020)

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Editorial Material Allergy

Recent progresses and perspectives in autoimmune bullous diseases

Christian D. Sadik et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Autoantibody-positive healthy individuals with lower lupus risk display a unique immuneendotype

Samantha Slight-Webb et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants

Yannic C. Bartsch et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Dermatology

TYK2/JAK1 Inhibitor PF-06700841 in Patients with Plaque Psoriasis: Phase IIa, Randomized, Double-Blind, Placebo-Controlled Trial

Seth B. Forman et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Article Rheumatology

Increasing Prevalence of Antinuclear Antibodies in the United States

Gregg E. Dinse et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Article Medicine, General & Internal

Immune-related adverse events of checkpoint inhibitors

Manuel Ramos-Casals et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Review Immunology

Autoimmunity and organ damage in systemic lupus erythematosus

George C. Tsokos

NATURE IMMUNOLOGY (2020)

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Article Dermatology

Can moderate-intensity aerobic exercise ameliorate atopic dermatitis?

Wang Kuk Son et al.

EXPERIMENTAL DERMATOLOGY (2020)

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Review Dermatology

Association Between Medication Use and Bullous Pemphigoid A Systematic Review and Meta-analysis

Sian-De Liu et al.

JAMA DERMATOLOGY (2020)

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Article Dermatology

Evaluation of Risk of Bullous Pemphigoid With Initiation of Dipeptidyl Peptidase-4 Inhibitor vs Second-generation Sulfonylurea

Hemin Lee et al.

JAMA DERMATOLOGY (2020)

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Article Cell Biology

Impact of diet and genes on murine autoimmune pancreatitis

Robert Jaster et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Endocrinology & Metabolism

Autoantibody Production in Obesity: Is There Evidence for a Link Between Obesity and Autoimmunity?

Christina Tsigalou et al.

CURRENT OBESITY REPORTS (2020)

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Review Rheumatology

The genetics of rheumatoid arthritis

Laura E. Dedmon

RHEUMATOLOGY (2020)

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Review Immunology

Environmental pollutants and the immune response

Takafumi Suzuki et al.

NATURE IMMUNOLOGY (2020)

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Review Immunology

COVID-19: Infection or Autoimmunity

Timothy Icenogle

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, General & Internal

ANCA-associated vasculitis

A. Richard Kitching et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Review Immunology

What Makes Antibodies Against G Protein-Coupled Receptors so Special? A Novel Concept to Understand Chronic Diseases

Gabriela Riemekasten et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Correction Psychiatry

Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers (vol 20, 411, 2020)

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Review Immunology

How COVID-19 induces cytokine storm with high mortality

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INFLAMMATION AND REGENERATION (2020)

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Review Immunology

The microbiome in autoimmune diseases

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CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2019)

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Article Rheumatology

Abrupt and unexpected stressful life events are followed with increased disease activity in spondyloarthritis: A two years web-based cohort study

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JOINT BONE SPINE (2019)

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Article Rheumatology

Effects of Aerobic and Resistance Exercise in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial

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ARTHRITIS CARE & RESEARCH (2019)

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Article Rheumatology

Human leukocyte antigen (HLA)-DRB1 allele polymorphisms and systemic sclerosis

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MODERN RHEUMATOLOGY (2019)

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Review Immunology

Dysregulation of T Follicular Helper Cells in Lupus

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JOURNAL OF IMMUNOLOGY (2019)

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Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance

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KIDNEY INTERNATIONAL (2019)

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Article Rheumatology

Affinity Maturation of the Anti-Citrullinated Protein Antibody Paratope Drives Epitope Spreading and Polyreactivity in Rheumatoid Arthritis

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ARTHRITIS & RHEUMATOLOGY (2019)

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Editorial Material Rheumatology

Subclassifying ANCA-associated vasculitis: a unifying view of disease spectrum

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RHEUMATOLOGY (2019)

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Article Microbiology

Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity

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CELL HOST & MICROBE (2019)

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Article Pharmacology & Pharmacy

Predicting Rheumatoid Arthritis in At-risk Individuals

Laurette van Boheemen et al.

CLINICAL THERAPEUTICS (2019)

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Bystander activation and autoimmunity

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JOURNAL OF AUTOIMMUNITY (2019)

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An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

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NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Immunology

Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid

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FRONTIERS IN IMMUNOLOGY (2019)

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Article Immunology

A Cross-Sectional Study Comparing the Prevalence of Bullous Pemphigoid Autoantibodies in 275 Cases of Type II Diabetes Mellitus Treated With or Without Dipeptidyl Peptidase-IV Inhibitors

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FRONTIERS IN IMMUNOLOGY (2019)

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Review Medicine, General & Internal

Pemphigus

Enno Schmidt et al.

LANCET (2019)

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Rotating night shift work and risk of multiple sclerosis in the Nurses' Health Studies

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OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2019)

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Review Cell Biology

Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond

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CELLS (2019)

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Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

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NATURE COMMUNICATIONS (2019)

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A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity

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CELL HOST & MICROBE (2019)

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Review Immunology

Pathogenic memory plasma cells in autoimmunity

Hyun-Dong Chang et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

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Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis

Peter Lamprecht et al.

JOURNAL OF AUTOIMMUNITY (2019)

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Article Dermatology

Higher Frequency of Dipeptidyl Peptidase-4 Inhibitor Intake in Bullous Pemphigoid Patients than in the French General Population

Marthe Plaquevent et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Review Rheumatology

Clinical and pathophysiologic relevance of autoantibodies in rheumatoid arthritis

Sara de Brito Rocha et al.

ADVANCES IN RHEUMATOLOGY (2019)

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Patterns of ANA+ B cells for SLE patient stratification

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JCI INSIGHT (2019)

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Geospatial Correlation of Amyopathic Dermatomyositis With Fixed Sources of Airborne Pollution: A Retrospective Cohort Study

David R. Pearson et al.

FRONTIERS IN MEDICINE (2019)

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Review Rheumatology

An autumn tale: geriatric rheumatoid arthritis

Senol Kobak et al.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2018)

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Article Immunology

Physical activity and autoimmune diseases: Get moving and manage the disease

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AUTOIMMUNITY REVIEWS (2018)

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Cigarette smoke extract acts directly on CD4 T cells to enhance Th1 polarization and reduce memory potential

Joanne D. Tejero et al.

CELLULAR IMMUNOLOGY (2018)

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Article Dermatology

High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice

Yuko Higashi et al.

EXPERIMENTAL DERMATOLOGY (2018)

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Article Allergy

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Letter Dermatology

Vildagliptin Significantly Increases the Risk of Bullous Pemphigoid: A Finnish Nationwide Registry Study

Outi Varpuluoma et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Review Dermatology

Influence of cigarette smoking on pemphigus - a systematic review and pooled analysis of the literature

O. Lai et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis

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LIFE SCIENCES (2018)

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Review Rheumatology

The B cell response to citrullinated antigens in the development of rheumatoid arthritis

Hans Ulrich Scherer et al.

NATURE REVIEWS RHEUMATOLOGY (2018)

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Article Multidisciplinary Sciences

Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome

Laura Kervezee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Multidisciplinary Sciences

C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism

Guang Sheng Ling et al.

SCIENCE (2018)

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Acute exposure to diesel and sewage biodiesel exhaust causes pulmonary and systemic inflammation in mice

Jose Mara de Brito et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

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Article Rheumatology

Affinity Maturation Drives Epitope Spreading and Generation of Proinflammatory Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis

Serra E. Elliott et al.

ARTHRITIS & RHEUMATOLOGY (2018)

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Article Respiratory System

Cigarette smoke exposure promotes differentiation of CD4+ T cells toward Th17 cells by CD40-CD40L costimulatory pathway in mice

Yi Liang et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2018)

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Review Immunology

Pathogenetic and Clinical Aspects of Anti-neutrophil Cytoplasmic Autoantibody-Associated vasculitides

Peter Lamprecht et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis

Yannic C. Bartsch et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Targeting Ige Antibodies by Immunoadsorption in Atopic Dermatitis

Michael Kasperkiewicz et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Mechanistic immunological based classification of rheumatoid arthritis

Dennis McGonagle et al.

AUTOIMMUNITY REVIEWS (2018)

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Letter Immunology

Cigarette smoking associates inversely with a cluster of two autoimmune diseases: ulcerative colitis and pemphigus

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IMMUNOLOGIC RESEARCH (2018)

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Article Immunology

In situ detection of PR3-ANCA+ B cells and alterations in the variable region of immunoglobulin genes support a role of inflamed tissue in the emergence of auto-reactivity in granulomatosis with polyangiitis

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JOURNAL OF AUTOIMMUNITY (2018)

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Article Multidisciplinary Sciences

Extensive impact of non-antibiotic drugs on human gut bacteria

Lisa Maier et al.

NATURE (2018)

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Review Immunology

Follicular Helper T Cells in Systemic Lupus Erythematosus

Sun Jung Kim et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Otavio Cabral-Marques et al.

NATURE COMMUNICATIONS (2018)

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Tobacco Use Worldwide: Legislative Efforts to Curb Consumption

M. Teresa Perez-Warnisher et al.

ANNALS OF GLOBAL HEALTH (2018)

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Article Immunology

Suppression of Neutrophil Antimicrobial Functions by Total Particulate Matter From Cigarette Smoke

Yao Zhang et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Rheumatology

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease

Yuriy Baglaenko et al.

ARTHRITIS RESEARCH & THERAPY (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

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Review Medicine, General & Internal

The Growing Incidence of Bullous Pemphigoid: Overview and Potential Explanations

Khalaf Kridin et al.

FRONTIERS IN MEDICINE (2018)

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Article Cell Biology

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8

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JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Immunology

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease

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NATURE IMMUNOLOGY (2017)

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Review Rheumatology

Update on the genetic architecture of rheumatoid arthritis

Kwangwoo Kim et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

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Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?

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ONCOTARGET (2017)

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First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial

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LANCET (2017)

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Article Medicine, General & Internal

Pathogenetic insights from the treatment of rheumatoid arthritis

Iain B. McInnes et al.

LANCET (2017)

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Circadian clock cryptochrome proteins regulate autoimmunity

Qi Cao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Letter Rheumatology

Stressful life events as a trigger for rheumatoid arthritis onset within a year: a case-control study

J. Gross et al.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2017)

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Review Rheumatology

Exercise and physical activity in systemic lupus erythematosus: A systematic review with meta-analyses

Tom O'Dwyer et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2017)

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Review Rheumatology

Obesity and the risk of systemic lupus erythematosus among women in the Nurses' Health Studies

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SEMINARS IN ARTHRITIS AND RHEUMATISM (2017)

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Transcriptomic analyses and leukocyte telomere length measurement in subjects exposed to severe recent stressful life events

N. Lopizzo et al.

TRANSLATIONAL PSYCHIATRY (2017)

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Daily Moderate Exercise Is Beneficial and Social Stress Is Detrimental to Disease Pathology in Murine Lupus Nephritis

Saba I. Aqel et al.

FRONTIERS IN PHYSIOLOGY (2017)

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Review Immunology

Mechanisms of Autoantibody-Induced Pathology

Ralf J. Ludwig et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Pemphigus

Michael Kasperkiewicz et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid

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PLOS ONE (2017)

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Article Rheumatology

Relationship between shift work and the onset of rheumatoid arthritis

Anna Karin Hedstrom et al.

RMD OPEN (2017)

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Association Between Inflammatory Skin Disease and Cardiovascular and Cerebrovascular Co-Morbidities in US Adults: Analysis of Nationwide Inpatient Sample Data

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AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2017)

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Article Dermatology

Increased frequency of multiple sclerosis among patients with bullous pemphigoid: a population-based cohort study on comorbidities anchored around the diagnosis of bullous pemphigoid

L. Kibsgaard et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

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Article Medicine, Research & Experimental

Estrogens regulate glycosylation of IgG in women and men

Altan Ercan et al.

JCI INSIGHT (2017)

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Article Rheumatology

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

Caroline von Spee-Mayer et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

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Article Nutrition & Dietetics

Long-term effects of weight reduction on the severity of psoriasis in a cohort derived from a randomized trial: a prospective observational follow-up study

Peter Jensen et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2016)

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Review Pathology

Mechanisms of Disease: Pemphigus and Bullous Pemphigoid

Christoph M. Hammers et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

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Review Immunology

Association between stressful life events and autoimmune diseases: A systematic review and meta-analysis of retrospective case-control studies

Brunetta Porcelli et al.

AUTOIMMUNITY REVIEWS (2016)

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Letter Immunology

Antibodies against angiotensin II type 1 receptor (AT1R) and endothelin receptor type A (ETAR) in systemic sclerosis (SSc)-response

Gabriela Riemekasten et al.

AUTOIMMUNITY REVIEWS (2016)

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Review Immunology

Smoke and autoimmunity: The fire behind the disease

Carlo Perricone et al.

AUTOIMMUNITY REVIEWS (2016)

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Article Immunology

Family study of monozygotic twins affected by pemphigus vulgaris

Adriana Martinelli Salathiel et al.

HUMAN IMMUNOLOGY (2016)

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Article Immunology

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity

Stephanie Hucke et al.

JOURNAL OF AUTOIMMUNITY (2016)

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Article Immunology

Skin microbiota-associated inflammation precedes autoantibody induced tissue damage in experimental epidermolysis bullosa acquisita

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JOURNAL OF AUTOIMMUNITY (2016)

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Review Immunology

The genetic basis of systemic lupus erythematosus: What are the risk factors and what have we learned

Maria Teruel et al.

JOURNAL OF AUTOIMMUNITY (2016)

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Review Immunology

Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies

Rufei Lu et al.

JOURNAL OF AUTOIMMUNITY (2016)

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Letter Dermatology

Prevalence and Age Distribution of Pemphigus and Pemphigoid Diseases in Germany

Franziska Huebner et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

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Article Rheumatology

Monocytic Angiotensin and Endothelin Receptor Imbalance Modulate Secretion of the Profibrotic Chemokine Ligand 18

Judith Rademacher et al.

JOURNAL OF RHEUMATOLOGY (2016)

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The economic burden of physical inactivity: a global analysis of major non-communicable diseases

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LANCET (2016)

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Review Medicine, General & Internal

Rheumatoid arthritis

Josef S. Smolen et al.

LANCET (2016)

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Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

Jun Wang et al.

NATURE GENETICS (2016)

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Review Rheumatology

Beyond pan-B-cell-directed therapy - new avenues and insights into the pathogenesis of SLE

Thomas Doerner et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

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Review Rheumatology

New insights into the immunopathogenesis of systemic lupus erythematosus

George C. Tsokos et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

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Article Multidisciplinary Sciences

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

Christoph T. Ellebrecht et al.

SCIENCE (2016)

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Article Multidisciplinary Sciences

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Yuhsuke Ohmi et al.

NATURE COMMUNICATIONS (2016)

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Article Rheumatology

Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity

Samantha Slight-Webb et al.

ARTHRITIS & RHEUMATOLOGY (2016)

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Article Clinical Neurology

Shift work at young age is associated with increased risk of multiple sclerosis in a Danish population

S. Gustavsen et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2016)

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Article Medicine, General & Internal

Systemic lupus erythematosus

Arvind Kaul et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

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Article Multidisciplinary Sciences

Psychiatric and neurological disorders are associated with bullous pemphigoid - a nationwide Finnish Care Register study

Anna-Kaisa Forsti et al.

SCIENTIFIC REPORTS (2016)

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Review Clinical Neurology

CNS autoimmune disease after Streptococcus pyogenes infections: animal models, cellular mechanisms and genetic factors

Tyler Cutforth et al.

FUTURE NEUROLOGY (2016)

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Review Immunology

Citrullination and autoimmunity

Guido Valesini et al.

AUTOIMMUNITY REVIEWS (2015)

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Autoantibody-defined risk for Type 1 diabetes mellitus in a general population of schoolchildren: results of the Karlsburg Type 1 Diabetes Risk Study after 18 years

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DIABETIC MEDICINE (2015)

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Article Immunology

Exacerbation of lupus nephritis by high sodium chloride related to activation of SGK1 pathway

Xi Yang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2015)

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Review Dermatology

Update on fogo selvagem, an endemic form of pemphigus foliaceus

Valeria Aoki et al.

JOURNAL OF DERMATOLOGY (2015)

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Article Immunology

Melanocyte antigen triggers autoimmunity in human psoriasis

Akiko Arakawa et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

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Article Immunology

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita

Hiroaki Iwata et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Oncology

The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita

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JOURNAL OF PATHOLOGY (2015)

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Article Medicine, General & Internal

High Sodium Intake Is Associated With Self-Reported Rheumatoid Arthritis: A Cross Sectional and Case Control Analysis Within the SUN Cohort

Eva Salgado et al.

MEDICINE (2015)

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Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

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NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Medicine, General & Internal

Pembrolizumab versus Ipilimumab in Advanced Melanoma

Caroline Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Genetics & Heredity

Prevalence of pemphigus and pemphigoid autoantibodies in the general population

Wiebke Pruessmann et al.

ORPHANET JOURNAL OF RARE DISEASES (2015)

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Article Medical Laboratory Technology

Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study

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TRANSLATIONAL RESEARCH (2015)

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Article Rheumatology

Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors

Adriano Taddeo et al.

ARTHRITIS RESEARCH & THERAPY (2015)

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Review Immunology

DPP4 in diabetes

Diana Roehrborn et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Rheumatology

Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort

Ian N. Bruce et al.

ANNALS OF THE RHEUMATIC DISEASES (2015)

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Review Allergy

Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms

Sylviane Muller et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2015)

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Article Clinical Neurology

Sodium intake is associated with increased disease activity in multiple sclerosis

Mauricio F. Farez et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2015)

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Article Immunology

Activation of C3a receptor is required in cigarette smoke-mediated emphysema

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MUCOSAL IMMUNOLOGY (2015)

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Article Multidisciplinary Sciences

IgG1 protects against renal disease in a mouse model of cryoglobulinaemia

Richard T. Strait et al.

NATURE (2015)

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Review Immunology

Infection-immunity liaison: Pathogen-driven autoimmune-mimicry (PDAIM)

Yukihiko Saeki et al.

AUTOIMMUNITY REVIEWS (2014)

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Review Immunology

Obesity in autoimmune diseases: Not a passive bystander

Mathilde Versini et al.

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Diet and physical exercise in psoriasis: a randomized controlled trial

L. Naldi et al.

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Increasing incidence of bullous pemphigoid in Northern Finland: a retrospective database study in Oulu University Hospital

A. -K. Forsti et al.

BRITISH JOURNAL OF DERMATOLOGY (2014)

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Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages

H. J. Metcalfe et al.

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Angiotensin II type 1 and 2 receptors and lymphatic vessels modulate lung remodeling and fibrosis in systemic sclerosis and idiopathic pulmonary fibrosis

Edwin Roger Parra et al.

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GAD autoantibody affinity in schoolchildren from the general population

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Co-occurrence of autoantibodies in healthy blood donors

Jasper Pruessmann et al.

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Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes

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Type I and type II Fc receptors regulate innate and adaptive immunity

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Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease

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Effects of Smoking and Shared Epitope on the Production of Anti-Citrullinated Peptide Antibody in a Japanese Adult Population

Chikashi Terao et al.

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Cigarette smoking and risk of rheumatoid arthritis: a dose-response meta-analysis

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Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies

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Association of Granulomatosis With Polyangiitis (Wegener's) With HLA-DPB1*04 and SEMA6A Gene Variants: Evidence Grom Genome-Wide Analysis

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Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease: lessons from animal models

Fleur Schaper et al.

CURRENT OPINION IN RHEUMATOLOGY (2013)

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The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies

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EXPERIMENTAL DERMATOLOGY (2013)

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S. Colafrancesco et al.

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T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies

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B Cells, Dendritic Cells, and Macrophages Are Required To Induce an Autoreactive CD4 Helper T Cell Response in Experimental Epidermolysis Bullosa Acquisita

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Stressful Life Events Antedating Chronic Childhood Arthritis

Kate M. Neufeld et al.

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Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Markus Kleinewietfeld et al.

NATURE (2013)

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Healthcare utilization and cost of systemic lupus erythematosus in a US managed care health plan

Cindy Garris et al.

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Molecular Mimicry as a Mechanism of Autoimmune Disease

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CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2012)

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Animal models of antineutrophil cytoplasm antibody-associated vasculitis

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CURRENT OPINION IN RHEUMATOLOGY (2012)

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Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

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Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs

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Twin studies in autoimmune disease: Genetics, gender and environment

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Marlene Rabinovitch

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Population-Specific Association between a Polymorphic Variant in ST18, Encoding a Pro-Apoptotic Molecule, and Pemphigus Vulgans

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Taming lupus-a new understanding of pathogenesis is leading to clinical advances

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NATURE MEDICINE (2012)

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Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

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Th17 Cell Enhances CD8 T-Cell Cytotoxicity via IL-21 Production in Emphysema Mice

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Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy: Prevalence and Comorbidity

Claudia Sardu et al.

PLOS ONE (2012)

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Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages

Akira Koarai et al.

RESPIROLOGY (2012)

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Involvement of stress in the pathogenesis of autoimmune thyroid disease: A prospective study

Grigoris Effraimidis et al.

PSYCHONEUROENDOCRINOLOGY (2012)

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Infection and autoimmune disease

Asli Gamze Sener et al.

RHEUMATOLOGY INTERNATIONAL (2012)

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Correlation of serum level of high mobility group box 1 with the burden of granulomatous inflammation in granulomatosis with polyangiitis (Wegener's)

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ANNALS OF THE RHEUMATIC DISEASES (2011)

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Air pollution in autoimmune rheumatic diseases: A review

Sylvia C. L. Farhat et al.

AUTOIMMUNITY REVIEWS (2011)

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Autoimmune diseases in patients with pemphigus and their first-degree relatives

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INTERNATIONAL JOURNAL OF DERMATOLOGY (2011)

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Complement-Fixing Anti-Type VII Collagen Antibodies Are Induced in Th1-Polarized Lymph Nodes of Epidermolysis Bullosa Acquisita-Susceptible Mice

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Generation of Antibodies of Distinct Subclasses and Specificity Is Linked to H2s in an Active Mouse Model of Epidermolysis Bullosa Acquisita

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Risk Factors for Bullous Pemphigoid in the Elderly: A Prospective Case-Control Study

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

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MECHANISMS OF DISEASE Systemic Lupus Erythematosus

George C. Tsokos

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Review Medicine, General & Internal

MECHANISMS OF DISEASE The Pathogenesis of Rheumatoid Arthritis

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NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease

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Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells

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TOXICOLOGY IN VITRO (2011)

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Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies

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ANNALS OF THE RHEUMATIC DISEASES (2010)

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Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

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ANNALS OF THE RHEUMATIC DISEASES (2010)

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Editorial Material Rheumatology

Serum HMGB1 levels are increased in active Wegener's granulomatosis and differentiate between active forms of ANCA-associated vasculitis

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ANNALS OF THE RHEUMATIC DISEASES (2010)

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Long-Term Impact of Delay in Assessment of Patients With Early Arthritis

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ARTHRITIS AND RHEUMATISM (2010)

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The prevalence of 30 ICD-10 autoimmune diseases in Denmark

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IMMUNOLOGIC RESEARCH (2010)

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Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4+:CD8+ T-cell ratios are reversed by smoking cessation: Influence of bone mass on immune cell response to and recovery from smoke exposure

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Development of self-reactive germinal center B cells and plasma cells in autoimmune FcγRIIB-deficient mice

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Infections and autoimmunity: the multifaceted relationship

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A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

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Complement: a key system for immune surveillance and homeostasis

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The role of defective clearance of apoptotic cells in systemic autoimmunity

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Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Local inflammation occurs before systemic inflammation in patients with COPD

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Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents

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Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis?

Frauke Foerger et al.

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Reversible changes in serum immunoglobulin galactosylation during the immune response and treatment of inflammatory autoimmune arthritis

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Drug-induced subacute cutaneous lupus erythematosus: a paradigm for bedside-to-bench patient-oriented translational clinical investigation

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Drug-induced autoimmunity

Fatma Dedeoglu

CURRENT OPINION IN RHEUMATOLOGY (2009)

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Development of an IgG4-Based Predictor of Endemic Pemphigus Foliaceus (Fogo Selvagem)

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Cytokine Switch and Bystander Suppression of Autoimmune Responses to Multiple Antigens in Experimental Autoimmune Encephalomyelitis by a Single Recombinant T-Cell Receptor Ligand

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Cigarette Smoking and Cutaneous Damage in Systemic Lupus Erythematosus

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JOURNAL OF RHEUMATOLOGY (2009)

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Finding the missing heritability of complex diseases

Teri A. Manolio et al.

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Article Respiratory System

Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation

Esmaeil Mortaz et al.

RESPIRATORY RESEARCH (2009)

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The relationship between plasma microparticles and disease manifestations in patients with systemic sclerosis

Serena Guiducci et al.

ARTHRITIS AND RHEUMATISM (2008)

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Airway infiltration of CD4+CCR6+Th17 type cells associated with chronic cigarette smoke induced airspace enlargement

Oliver J. Harrison et al.

IMMUNOLOGY LETTERS (2008)

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Review Cell Biology

Cigarette smoking and innate immunity

H. Mehta et al.

INFLAMMATION RESEARCH (2008)

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Impact of smoking on pemphigus

Mahin Valikhani et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2008)

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Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice

Clinton S. Robbins et al.

JOURNAL OF IMMUNOLOGY (2008)

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Relation between stressful life events, neuropeptides and cytokines: results from the LISA birth cohort study

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PEDIATRIC ALLERGY AND IMMUNOLOGY (2008)

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Serum proteomic profiling associated with immune system impaired by stress using ProteinChip technology

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NEUROIMMUNOMODULATION (2008)

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Fc gamma receptors as regulators of immune responses

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NATURE REVIEWS IMMUNOLOGY (2008)

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Circulating pemphigus autoantibodies in healthy relatives of pemphigus patients:: coincidental phenomenon with a risk of disease development?

Jolanta Dorota Torzecka et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2007)

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Distribution of collagen XVII in the human brain

Allan Seppaenen et al.

BRAIN RESEARCH (2007)

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Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms

Latisha D. Heinlen et al.

ARTHRITIS AND RHEUMATISM (2007)

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Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus

Beatriz Duarte Palma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)

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Role of different pathways of the complement cascade in experimental bullous pemphigoid

Kelly C. Nelson et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation

Yoshikatsu Kaneko et al.

SCIENCE (2006)

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Effect of smoking on crevicular polymorphonuclear neutrophil function in periodontally healthy subjects

A Güntsch et al.

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Article Biochemistry & Molecular Biology

Collagen XVII is expressed in human CNS neurons

A Seppänen et al.

MATRIX BIOLOGY (2006)

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Article Immunology

TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE

M Ehlers et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

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A new model for an etiology of rheumatoid arthritis

L Klareskog et al.

ARTHRITIS AND RHEUMATISM (2006)

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Review Rheumatology

Cigarette smoking and autoimmune disease: what can we learn from epidemiology?

K. H. Costenbader et al.

LUPUS (2006)

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Article Immunology

Effects of MHC and gender on lupus-like Autoimmunity in nba2 Congenic mice

MR Gubbels et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Endocrinology & Metabolism

In insulin-autoantibody-positive children from the general population, antibody affinity identifies those at high and low risk

M Schlosser et al.

DIABETOLOGIA (2005)

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Article Immunology

C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist

LH Bao et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2005)

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Article Immunology

Stress is not associated with thyroid peroxidase autoantibodies in euthyroid women

TGA Strieder et al.

BRAIN BEHAVIOR AND IMMUNITY (2005)

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The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus

MT McClain et al.

ARTHRITIS AND RHEUMATISM (2004)

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Article Medicine, General & Internal

Actual causes of death in the United States, 2000

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)

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Specific autoantibodies precede the symptoms of rheumatoid arthritis - A study of serial measurements in blood donors

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ARTHRITIS AND RHEUMATISM (2004)

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The effects of daily stress and stressful life events on the clinical symptomatology of patients with lupus erythematosus

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PSYCHOSOMATIC MEDICINE (2004)

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Article Biochemistry & Molecular Biology

HMGB1 is an endogenous immune adjuvant released by necrotic cells

P Rovere-Querini et al.

EMBO REPORTS (2004)

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Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

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BLOOD (2004)

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Article Immunology

Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice

BF Hoyer et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

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Article Rheumatology

Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors

Y Kawaguchi et al.

ARTHRITIS AND RHEUMATISM (2004)

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Article Medicine, General & Internal

Development of autoantibodies before the clinical onset of systemic lupus erythematosus

MR Arbuckle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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Article Rheumatology

Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis

S Rantapää-Dahlqvist et al.

ARTHRITIS AND RHEUMATISM (2003)

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Review Dermatology

Progress in the understanding of the pathology and pathogenesis of cutaneous drug eruptions - Implications for management

AN Crowson et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2003)

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Review Rheumatology

Drug-induced rheumatic syndromes

BL Brogan et al.

CURRENT OPINION IN RHEUMATOLOGY (2003)

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Article Immunology

Arthritis critically dependent on innate immune system players

H Ji et al.

IMMUNITY (2002)

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Article Medicine, General & Internal

A comparison of oral and topical corticosteroids in patients with bullous pemphigoid

P Joly et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Article Endocrinology & Metabolism

Family characteristics and life events before the onset of autoimmune type 1 diabetes in young adults -: A nationwide study

B Littorin et al.

DIABETES CARE (2001)

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