期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 24, 页码 6445-6458出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1128-16.2016
关键词
deep brain stimulation; dyskinesia; electrocorticography; local field potentials; motor cortex; Parkinson's disease
资金
- University of California
- National Institute of Neurological Disorders and Stroke [R01 NS090913-01]
- Michael J. Fox Foundation
Hyperkinetic states are common in human movement disorders, but their neural basis remains uncertain. One such condition is dyskinesia, a serious adverse effect of medical and surgical treatment for Parkinson's disease (PD). To study this, we used a novel, totally implanted, bidirectional neural interface to obtain multisite long-term recordings. We focus our analysis on two patients with PD who experienced frequent dyskinesia and studied them both at rest and during voluntary movement. We show that dyskinesia is associated with a narrowband gamma oscillation in motor cortex between 60 and 90 Hz, a similar, though weaker, oscillation in subthalamic nucleus, and strong phase coherence between the two. Dyskinesia-related oscillations are minimally affected by voluntary movement. When dyskinesia persists during therapeutic deep brain stimulation (DBS), the peak frequency of this signal shifts to half the stimulation frequency. These findings suggest a circuit-level mechanism for the generation of dyskinesia as well as a promising control signal for closed-loop DBS.
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