期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 29, 页码 7676-7692出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4201-15.2016
关键词
brain network integration; brain states; functional connectivity; neuronal network analysis; spiking activity; wakefulness and sleep
资金
- European Union (EU FP7 ICT Grant) [270108]
- Netherlands Organization for Scientific Research (NWO ALW-Open Grant) [820.02.020]
- EU [720270]
- Human Brain Project HBP SGA1
- FLAG-ERA JTC project CANON (NWO)
Behavioral states arecommonly considered global phenomena with homogeneous neural determinants. However, recent studies indicate that behavioral states modulate spiking activity with neuron-level specificity as a function of brain area, neuronal subtype, and preceding history. Although functional connectivity also strongly depends on behavioral state at a mesoscopic level and is globally weaker in non-REM (NREM) sleep and anesthesia than wakefulness, it is unknown how neuronal communication is modulated at the cellular level. We hypothesize that, as for neuronal activity, the influence of behavioral states on neuronal coupling strongly depends on type, location, and preceding history of involved neurons. Here, we applied nonlinear, information-theoretical measures of functional connectivity to ensemble recordings with single-cell resolution to quantify neuronal communication in the neocortex and hippocampus of rats during wakefulness and sleep. Although functional connectivity (measured in terms of coordination between firing rate fluctuations) was globally stronger in wakefulness than in NREM sleep (with distinct traits for cortical and hippocampal areas), the drop observed during NREM sleep was mainly determined by a loss of inter-areal connectivity between excitatory neurons. Conversely, local (intra-area) connectivity and long-range (inter-areal) coupling between interneurons were preserved during NREM sleep. Furthermore, neuronal networks that were either modulated or not by a behavioral task remained segregated during quiet wakefulness and NREM sleep. These results show that the drop in functional connectivity during wake-sleep transitions globally holds true at the cellular level, but confine this change mainly to long-range coupling between excitatory neurons.
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