Digital Twins for Predictive, Preventive Personalized, and Participatory Treatment of Immune-Mediated Diseases

Editorial Material Critical Care Medicine

An Oversight in Oversight Reconciling the Medical Device Industry, Clinicians, and Regulation

Kelly C. Landeen et al.

CHEST (2022)

Article Genetics & Heredity

A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets

Xinxiu Li et al.

Summary: This study presents a scalable framework for modeling dynamic changes in medical digital twins on cellulome- and genome-wide scales, in order to prioritize upstream regulators (URs) for biomarker and drug discovery.

GENOME MEDICINE (2022)

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Article Multidisciplinary Sciences

Pathogenic variants damage cell composition and single-cell transcription in cardiomyopathies

Daniel Reichart et al.

SCIENCE (2022)

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Review Health Care Sciences & Services

The health digital twin to tackle cardiovascular disease-a review of an emerging interdisciplinary field

Genevieve Coorey et al.

Summary: Precision medicine in cardiovascular disease has the potential to benefit from the concept of digital twins, where virtual representations of patients receive real-time updates on various data variables to predict diseases and optimize treatment selection. Through a systematic literature review, it was found that digital twin research in the field of cardiovascular disease is interdisciplinary and globally established, with numerical simulation models being the main focus. However, implementation challenges include ethical constraints and clinical barriers to the adoption of decision tools based on artificial intelligence systems.

NPJ DIGITAL MEDICINE (2022)

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Article Cell Biology

Gene-environment interactions explain a substantial portion of variability of common neuropsychiatric disorders

Hanxin Zhang et al.

Summary: This study explores the contribution of gene-environment interactions in ten major neuropsychiatric disorders, finding that while they only account for a small portion of total phenotypic variance in some disorders, they play a significantly larger role in others. The research integrates clinical data, family pedigrees, spatial distribution of individuals, socio-economic and demographic factors, and environmental measurements.

CELL REPORTS MEDICINE (2022)

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Article Computer Science, Interdisciplinary Applications

Virtual patients for mechanical ventilation in the intensive care unit

Cong Zhou et al.

Summary: The study develops a digital clone model to predict lung mechanics in response to changes in mechanical ventilation, enabling personalised care. Results show that the virtual patient model accurately predicts patient-specific lung responses, guiding personalised and optimised mechanical ventilation therapy.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2021)

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Editorial Material Multidisciplinary Sciences

Using digital twins in viral infection

Reinhard Laubenbacher et al.

SCIENCE (2021)

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News Item Medicine, General & Internal

NHS to trial artificial pancreas for patients with type 1 diabetes

Gareth Iacobucci

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Health Care Sciences & Services

Digital Twins: From Personalised Medicine to Precision Public Health

Maged N. Kamel Boulos et al.

Summary: A digital twin is a virtual model of a physical entity, increasingly used in various industry sectors. In the fields of medicine and public health, digital twin technology can drive radical transformation towards precision medicine and personalized treatments. Digital twins enable learning, discovering new knowledge, and hypothesis generation, while also playing a key role in formulating highly personalized treatments and interventions.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Medicine, General & Internal