期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 116, 期 2, 页码 892-903出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00103.2016
关键词
extracellular action potential; spike sorting; ground truth; juxtacellular recording; polytrodes
资金
- European Union's Seventh Framework Programme (FP7) [600925]
- FCT-MCTES Doctoral Grant [SFRH/BD/76004/2011]
- Bial Foundation [190/12]
- Champalimaud Foundation
- Sainsbury Wellcome Centre
- Gatsby Charitable Foundation
- Wellcome Trust
- Fundação para a Ciência e a Tecnologia [SFRH/BD/76004/2011] Funding Source: FCT
Cross-validating new methods for recording neural activity is necessary to accurately interpret and compare the signals they measure. Here we describe a procedure for precisely aligning two probes for in vivo paired-recordings such that the spiking activity of a single neuron is monitored with both a dense extracellular silicon polytrode and a juxtacellular micropipette. Our new method allows for efficient, reliable, and automated guidance of both probes to the same neural structure with micrometer resolution. We also describe a new dataset of paired-recordings, which is available online. We propose that our novel targeting system, and ever expanding cross-validation dataset, will be vital to the development of new algorithms for automatically detecting/sorting single-units, characterizing new electrode materials/designs, and resolving nagging questions regarding the origin and nature of extracellular neural signals.
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