Hepato and renoprotective activity of Kappaphycus alvarezii ethanolic extract in cisplatin causes hepatic and kidney harm in Albino Wistar rats

In the current study, an ethanol extract of Kappaphycus alvarezii was tested for its ability to protect albino rats from cisplatin-induced hepato and nephrotoxicity. The addition of cisplatin (5 mg/kg) substantially increases the serum hepato-specific enzymes of ALP, ALT, AST, and bilirubin in rats. In comparison to the control group, total cholesterol and triglyceride levels were considerably higher. After 30 days of administration of K. alvarezii seaweed extract (250, 350, and 450 mg/kg of body wt.), the increased levels of liver marker enzymes compared to cisplatin-induced species was due to a considerable reduction. In comparison to cisplatin-induced rats, serum urea, uric acid, and creatinine levels were greater, whereas calcium, potassium, sodium, phosphorous, and protein levels were lower, with considerable normalization of histological architecture. The GC - MS data confirmed the presence of nine distinct chemicals. Overall, the current investigation discovered that an ethanol extract of K. alvarezii may protect albino rats against cisplatin-induced hepato and nephrotoxicity and that this was most likely due to active chemicals in the extract.

Automated summary

This study found that an ethanol extract of Kappaphycus alvarezii can effectively protect albino rats from cisplatin-induced hepato and nephrotoxicity. Cisplatin administration increased the levels of hepato-specific enzymes and lipid markers in rats, while the administration of K. alvarezii extract reduced these markers and improved histological architecture. The presence of nine distinct chemicals in the extract was confirmed by GC-MS analysis. Overall, the study suggests that K. alvarezii extract may protect albino rats against cisplatin-induced liver and kidney toxicity through its active chemicals.