Wave-theory-based analysis of a fiber optic bio-sensor illuminated by radially polarized Bessel-Gauss beam: an approach for early diagnosis of breast cancer with a high-resolution technique

With the establishment of validity using authoritative experimental results, an analytical investigation of an SPR-based fiber optic sensor, employing a wave-theory-based technique for determining breast cancer by shining a radi-ally polarized Bessel-Gauss (RPBG) beam, is proposed. First, by using a radially polarized Gaussian (RPG) beam, the observed sensitivity is 9404.61 dB/RIU, where the acquired results are in good concurrence with the experimen-tal data reported by Yan et al. [Chin. Opt. Lett.7, 909 (2009)]. Thus, the proposed theory has been validated with the reported experimental data. This theoretical analysis is further extended by utilizing an RPBG beam, where the observed sensitivity is 21,699.26 dB/RIU and 5846 nm/RIU, with a resolution of 4.61 x 10-7, which is 2.5 times superior to the reported results to date. By using an RPBG beam, the proposed method, to our best knowledge, is the first to achieve much higher sensitivity in the area of fiber optic breast cancer detection. The higher sensitivity achieved at lower concentrations of an HER2 biomarker has led to the idea of early diagnosis of breast cancer by optically assessing it at its earlier stage using a high-resolution wavelength-interrogation technique. (c) 2022 Optica Publishing Group

Automated summary

This study proposes an analytical investigation of an SPR-based fiber optic sensor for breast cancer detection using a wave-theory-based technique with a radially polarized Bessel-Gauss beam. The validity of the proposed theory is validated with experimental data, and the use of a radially polarized beam achieves higher sensitivity and resolution compared to previous results. This method shows promise for early diagnosis of breast cancer by optically assessing it at its earlier stage.