期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 87, 期 11, 页码 1212-1217出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2016-313979
关键词
-
资金
- Multiple Sclerosis Society in the UK
- UCL UCLH Comprehensive Biomedical Research Centre
- National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative)
- Engineering and Physical Sciences Research Council [EP/H046410/1, EP/J020990/1, EP/K005278]
- Medical Research Council [MR/J01107X/1]
- EU-FP7 project VPH-DARE@IT [FP7- ICT-2011-9-601055]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative) [BW.mn.BRC10269]
- MS Society of Great Britain and Northern Ireland
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- Engineering and Physical Sciences Research Council [EP/J020990/1, EP/H046410/1] Funding Source: researchfish
- Health and Care Research Wales [HF-14-21] Funding Source: researchfish
- Medical Research Council [MR/J01107X/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10058] Funding Source: researchfish
- EPSRC [EP/J020990/1, EP/H046410/1] Funding Source: UKRI
- MRC [MR/J01107X/1] Funding Source: UKRI
Objective To assess the association between proximity to the inner (ventricular and aqueductal) and outer (pial) surfaces of the brain and the distribution of normal appearing white matter (NAWM) and grey matter (GM) abnormalities, and white matter (WM) lesions, in multiple sclerosis (MS). Methods 67 people with relapse-onset MS and 30 healthy controls were included in the study. Volumetric T1 images and high-resolution (1 mm(3)) magnetisation transfer ratio (MTR) images were acquired and segmented into 12 bands between the inner and outer surfaces of the brain. The first and last bands were discarded to limit partial volume effects with cerebrospinal fluid. MTR values were computed for all bands in supratentorial NAWM, cerebellar NAWM and brainstem NA tissue, and deep and cortical GM. Band WM lesion volumes were also measured. Results Proximity to the ventricular surfaces was associated with progressively lower MTR values in the MS group but not in controls in supratentorial and cerebellar NAWM, brainstem NA and in deep and cortical GM. The density of WM lesions was associated with proximity to the ventricles only in the supratentorial compartment, and no link was found with distance from the pial surfaces. Conclusions In MS, MTR abnormalities in NAWM and GM are related to distance from the inner and outer surfaces of the brain, and this suggests that there is a common factor underlying their spatial distribution. A similar pattern was not found for WM lesions, raising the possibility that different factors promote their formation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据