Enzalutamide or Abiraterone Acetate With Prednisone in the Treatment of Metastatic Castration-resistant Prostate Cancer in Real-life Clinical Practice: A Long-term Single Institution Experience

Background/Aim: Enzalutamide (ENZ) and abiraterone acetate with prednisone (AAP) represent novel hormonal therapies used in the treatment of metastatic castration-resistant prostate cancer (mCRPC). The aim of the study was to assess the long-term outcome of mCRPC patients treated with ENZ or AAP in real-life clinical practice. Patients and Methods: The outcomes of 337 mCRPC patients treated with ENZ or AAP were retrospectively analysed. Results: Median radiographic progression-free (rPFS) and overall survival (OS) of patients treated in the first line (pre -chemotherapy) was 13.89 (95% CI=12.40-16.80) and 31.02 (95% CI=24.27-37.44) months vs. 10.97 (95% CI=8.97-14.82) and 26.57 (95% CI=15.97-33.92) months for those treated in the second line (post-chemotherapy). We found inferior survival for patients with synchronous metastases, high Gleason score (GS) and visceral metastases. Conclusion: The efficacy of both ENZ and AAP in mCRPC patients is herein confirmed. Synchronous metastases, high GS and visceral metastases were identified as significant adverse prognostic factors.

Automated summary

This study retrospectively analyzed the long-term outcomes of 337 mCRPC patients treated with ENZ or AAP. The study confirmed the efficacy of both ENZ and AAP in mCRPC patients, and identified synchronous metastases, high GS, and visceral metastases as significant adverse prognostic factors.