Tenecteplase Improves Reperfusion across Time in Large Vessel Stroke

Article Neuroimaging

Early recanalization in large-vessel occlusion stroke patients transferred for endovascular treatment

Nerea Arrarte Terreros et al.

Summary: Early recanalization in transferred EVT patients with LVO stroke is associated with clinical improvement, more distal occlusions, and shorter thrombi at baseline imaging.

JOURNAL OF NEUROINTERVENTIONAL SURGERY (2022)

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Article Medicine, General & Internal

Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas The RACECAT Randomized Clinical Trial

Natalia Perez de la Ossa et al.

Summary: This study aimed to compare the outcomes of transporting patients with suspected large-vessel occlusion stroke directly to a thrombectomy-capable center versus to the closest local stroke center in nonurban areas of Catalonia, Spain. The results showed no significant difference in 90-day neurological outcomes between the two transport strategies.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Clinical Neurology

Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne Mobile Stroke Unit (TASTE-A): a phase 2, randomised, open-label trial

Andrew Bivard et al.

Summary: The use of tenecteplase in a mobile stroke unit in Melbourne, Australia resulted in superior reperfusion compared to alteplase upon hospital arrival, with no safety concerns.

LANCET NEUROLOGY (2022)

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Article Clinical Neurology

Time from IV Thrombolysis to Thrombectomy and Outcome in Acute Ischemic Stroke

Francois Zhu et al.

Summary: The study analyzed the association between the time from IVT to EVT and functional outcome in patients with acute ischemic stroke, showing that a longer time was associated with worse outcomes. This provides a basis for further studies to optimize treatment timing.

ANNALS OF NEUROLOGY (2021)

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Article Clinical Neurology

Early Recanalization With Alteplase in Stroke Because of Large Vessel Occlusion in the ESCAPE Trial

Johanna M. Ospel et al.

Summary: Intravenous alteplase significantly influences the technical outcome of early recanalization, and early recanalization is a strong predictor for patients to achieve good outcomes. However, 59.0% of patients still failed to achieve early reperfusion.

STROKE (2021)

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Article Clinical Neurology

Pre- and Interhospital Workflow Times for Patients With Large Vessel Occlusion Stroke Transferred for Endovasvular Thrombectomy

Laura C. C. van Meenen et al.

Summary: In patients transferred from a primary stroke center to a comprehensive stroke center for endovascular thrombectomy, the median time from first alarm to arrival at the receiving center was over 2.5 hours. Dispatch of ambulances with the highest level of urgency for endovascular thrombectomy transfers significantly decreased the time to treatment.

FRONTIERS IN NEUROLOGY (2021)

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Article Medicine, General & Internal