4.6 Review

R-spondin family biology and emerging linkages to cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pathology

Tumour mutational burden: an overview for pathologists

Kenneth D. Doig et al.

Summary: Cancer immunotherapy shows promise but its effects vary among patients and tumor types. Objective diagnostic biomarkers are needed to predict patient responses to immunotherapies. Tumor mutational burden (TMB) is one such biomarker that can stratify patients for response to immune checkpoint inhibitor therapies.

PATHOLOGY (2022)

Article Oncology

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Andreas Seeber et al.

Summary: The molecular features of colorectal cancers with RSPOfp/RNF43 mutations were characterized in this study, revealing new RSPO fusion events and identifying additional mutations associated with RSPOfp and RNF43 mutations. The findings have important implications for the development of therapeutic strategies targeting these mutations.

CLINICAL CANCER RESEARCH (2022)

Article Gastroenterology & Hepatology

Expression of R-Spondin 1 in ApcMin/+ Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling

Marianne Lahde et al.

Summary: Expression of RSPO1 in ApcMin/thorn mice increases apoptosis and reduces proliferation and Wnt signaling in adenoma cells, resulting in development of fewer and smaller intestinal tumors and longer mouse survival.

GASTROENTEROLOGY (2021)

Review Biochemistry & Molecular Biology

The role of R-spondin proteins in cancer biology

Eline J. ter Steege et al.

Summary: RSPO proteins play a crucial role in activating the Wnt/beta-catenin signaling pathway in stem cells and progenitor cells. Deregulation of RSPOs has been implicated in various cancer types, with potential for therapeutic targeting in cancer cases with RSPO overrepresentation.

ONCOGENE (2021)

Article Oncology

Tumor Microenvironment-Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy

Yuting Tang et al.

Summary: R-spondin 3 expression is associated with favorable prognosis and enhances infiltration and function of NK cells and T cells in tumors, leading to tumor regression, and also increases tumor sensitivity to anti-PD-1 therapy.

CANCER DISCOVERY (2021)

Article Cell Biology

RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia

Rui Sun et al.

Summary: RSPO2 promotes self-renewal of AML cells and may serve as a marker for poor prognosis. It maintains AML self-renewal independently of WNT by inhibiting BMP receptor signaling.

CELL REPORTS (2021)

Article Cell Biology

R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells

Zhilong Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth

Marie-Cecile De Cian et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Biochemistry & Molecular Biology

R-spondin-mediated WNT signaling potentiation in mammary and breast cancer development

Johanna M. Tocci et al.

IUBMB LIFE (2020)

Article Biotechnology & Applied Microbiology

R-Spondin 1 (RSPO1) Increases Mouse Intestinal Organoid Unit Size and Survivalin vitroand Improves Tissue-Engineered Small Intestine Formationin vivo

Gabriel Levin et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

LGR5 constitutively activates NF-κB signaling to regulate the growth of intestinal crypts

Shanshan Lai et al.

FASEB JOURNAL (2020)

Review Oncology

Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Oncology

RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer

Haifeng Gu et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Editorial Material Medicine, General & Internal

Understanding the role of the R-spondin 2-LGR4 system in tongue squamous cell carcinoma progression

Ahmed Al-Samadi et al.

EBIOMEDICINE (2019)

Article Cell Biology

R-spondin-3 induces secretory, antimicrobial Lgr5+ cells in the stomach

Michael Sigal et al.

NATURE CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

Christine Harnack et al.

NATURE COMMUNICATIONS (2019)

Article Gastroenterology & Hepatology

R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner

Caitlin B. Conboy et al.

HEPATOLOGY COMMUNICATIONS (2019)

Review Dentistry, Oral Surgery & Medicine

R-spondin signaling as a pivotal regulator of tissue development and homeostasis

Kenichi Nagano

JAPANESE DENTAL SCIENCE REVIEW (2019)

Article Biochemistry & Molecular Biology

R-Spondin-2 Is Upregulated in Idiopathic Pulmonary Fibrosis and Affects Fibroblast Behavior

Adrian Munguia-Reyes et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating beta-catenin

Shiying Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Chemistry, Medicinal

In silico discovery of quinoxaline derivatives as novel LRP5/6-sclerostin interaction inhibitors

Jiwon Choi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Integrative & Complementary Medicine

Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells

Shubin Yu et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Review Oncology

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

Nithya Krishnamurthy et al.

CANCER TREATMENT REVIEWS (2018)

Article Multidisciplinary Sciences

PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

Gediminas Greicius et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biology

R-spondins can potentiate WNT signaling without LGRs

Andres M. Lebensohn et al.

Article Cell & Tissue Engineering

R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass

M. Noelle Knight et al.

BONE RESEARCH (2018)

Article Oncology

Clinical value of R-spondins in triple-negative and metaplastic breast cancers

F. Coussy et al.

BRITISH JOURNAL OF CANCER (2017)

Article Medicine, Research & Experimental

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

Gabriele Picco et al.

EMBO MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/β-catenin signaling in cells

Miho Fujiwara et al.

FEBS LETTERS (2016)

Review Oncology

The emerging complexity of gene fusions in cancer

Fredrik Mertens et al.

NATURE REVIEWS CANCER (2015)

Article Biochemistry & Molecular Biology

Regulation of the Follistatin Gene by RSPO-LGR4 Signaling via Activation of the WNT/β-Catenin Pathway in Skeletal Myogenesis

Xiang Hua Han et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Recurrent R-spondin fusions in colon cancer

Somasekar Seshagiri et al.

NATURE (2012)

Article Multidisciplinary Sciences

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao et al.

NATURE (2012)

Article Multidisciplinary Sciences

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

Austin Gurney et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Biotechnology & Applied Microbiology

The R-spondin protein family

Wim B. M. de lau et al.

GENOME BIOLOGY (2012)

Article Biochemistry & Molecular Biology

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

Andrei Glinka et al.

EMBO REPORTS (2011)

Article Biochemistry & Molecular Biology

A WNT/β-Catenin Signaling Activator, R-spondin, Plays Positive Regulatory Roles during Skeletal Myogenesis

Xiang Hua Han et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Molecular analysis shows differential expression of R-spondin1 in zebrafish (Danio rerio) gonads

Yanmei Zhang et al.

MOLECULAR BIOLOGY REPORTS (2011)

Article Multidisciplinary Sciences

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

Wim de Lau et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Curtis A. Thorne et al.

NATURE CHEMICAL BIOLOGY (2010)

Article Endocrinology & Metabolism

Thrombospondins and Novel TSR-containing Proteins, R-spondins, Regulate Bone Formation and Remodeling

Kurt D. Hankenson et al.

Current Osteoporosis Reports (2010)

Article Multidisciplinary Sciences

R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/β-catenin pathway

Jingsong Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Developmental Biology

R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation

Ayhan Kocer et al.

BMC DEVELOPMENTAL BIOLOGY (2008)

Article Developmental Biology

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

Olga Kazanskaya et al.

DEVELOPMENT (2008)

Article Developmental Biology

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

Sheila M. Bell et al.

DEVELOPMENT (2008)

Article Biochemistry & Molecular Biology

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

Kazuma Tomizuka et al.

HUMAN MOLECULAR GENETICS (2008)

Article Mathematical & Computational Biology

Molecular modeling of the TSR domain of R-spondin 4

Leila Ayadi

BIOINFORMATION (2008)

Article Developmental Biology

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

Ju-Suk Nam et al.

DEVELOPMENTAL BIOLOGY (2007)

Article Reproductive Biology

Microarray analyses of newborn mouse ovaries lacking Nobox

Youngsok Choi et al.

BIOLOGY OF REPRODUCTION (2007)

Article Developmental Biology

R-spondin3 is required for mouse placental development

Motoko Aoki et al.

DEVELOPMENTAL BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors

Michael D. Gordon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)