Systematic review with meta-analysis of mid-regional pro-adrenomedullin (MR-proadm) as a prognostic marker in Covid-19-hospitalized patients

Letter Cardiac & Cardiovascular Systems

Myocarditis: A complication of COVID-19 and long-COVID-19 syndrome as a serious threat in modern cardiology

Lukasz Szarpak et al.

CARDIOLOGY JOURNAL (2022)

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Letter Cardiac & Cardiovascular Systems

Need to update cardiological guidelines to prevent COVID-19 related myocardial infarction and ischemic stroke

Gabriella Nucera et al.

CARDIOLOGY JOURNAL (2022)

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Article Medicine, General & Internal

Prognostic value of copeptin and mid-regional proadrenomedullin in COVID-19-hospitalized patients

Rita Indirli et al.

Summary: This study assessed the predictive value of copeptin and MR-proADM for in-hospital outcomes in COVID-19 patients. The results showed that both copeptin and MR-proADM could predict mortality, complications, and length of stay. They may be useful for early risk stratification and care intensification in COVID-19 patients.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Medicine, General & Internal

Age and clinical signs as predictors of COVID-19 symptoms and cycle threshold value

Ismail Dergaa et al.

Summary: This study investigated the relationship between different symptoms in COVID-19 patients and viral load. The study found that symptomatic patients were typically older with higher temperature and heart rate, lower blood oxygen saturation, and higher viral load. There was no correlation between age and viral load.

LIBYAN JOURNAL OF MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Cytokines from Bench to Bedside: A Retrospective Study Identifies a Definite Panel of Biomarkers to Early Assess the Risk of Negative Outcome in COVID-19 Patients

Martina Fabris et al.

Summary: The aim of this study was to identify relevant cytokines that can help select COVID-19 patients with worse prognosis. IL-6 was identified as the most important biomarker, and its combination with other cytokines and inflammatory markers improved the prediction of negative outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Virology

Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective Study

Davide Mangioni et al.

Summary: Coagulopathy and immune dysregulation have been identified as important causes of adverse outcomes in COVID-19. This study found that mid-region proadrenomedullin (MR-proADM) is associated with endothelial damage and has been proposed as a prognostic factor for COVID-19. In vitro interferon gamma (IFN gamma) production correlates with infection risk and mortality. MR-proADM at admission and during hospitalization is strongly associated with in-hospital mortality in COVID-19 pneumonia patients. Low in vitro IFN gamma production after the first week of hospitalization is linked to mortality in non-vaccinated patients, possibly identifying those with higher degrees of immune suppression.

VIRUSES-BASEL (2022)

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Article Medicine, General & Internal

Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department

Marilena Minieri et al.

Summary: This study analyzed data from 321 COVID-19 patients to assess the potential role of the biomarker MR-proADM in predicting in-hospital mortality and the need for ventilation. The results showed that MR-proADM had a good predictive performance in these aspects.

DIAGNOSTICS (2022)

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Article Immunology

Mid-regional Proadrenomedullin Biomarker Predicts Coronavirus Disease 2019 Clinical Outcomes: A US-Based Cohort Study

Natalie J. Atallah et al.

Summary: MR-proADM functions as a valuable biomarker for the early risk stratification and detection of severe disease progression of patients with COVID-19. In the prediction of death, MR-proADM performed better compared to many other commonly used biomarkers.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Medicine, General & Internal

Prognostic value of proadrenomedullin in patients with COVID-19 pneumonia

Aleksandr A. A. Astapovskii et al.

Summary: This study found that MR-proADM has a higher prognostic value in predicting the outcome of patients with COVID-19 compared to routine inflammatory markers and the National Early Warning Score (NEWS).

FRONTIERS IN MEDICINE (2022)

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Article Infectious Diseases

Mid-Regional Pro-Adrenomedullin as a Prognostic Factor for Severe COVID-19 ARDS

Etienne de Montmollin et al.

Summary: This study aimed to evaluate MR-proADM as a prognostic biomarker and marker of bacterial superinfection in severe SARS-CoV-2 infection. The results showed that MR-proADM is a good predictor of outcome in severe SARS-CoV-2 infection and could be a useful tool to assess bacterial superinfection in COVID-19 patients.

ANTIBIOTICS-BASEL (2022)

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Article Anesthesiology

Mid-regional pro-adrenomedullin as a predictor of in-hospital mortality in adult patients with COVID-19: a single-centre prospective study

Dmitry Popov et al.

Summary: This study found that MR-proADM has the highest predictive value for in-hospital mortality in patients with COVID-19 compared to other indicators. Non-survivors had older age, lower hemoglobin oxygen saturation, lower lymphocyte levels, higher lactate dehydrogenase and aspartate aminotransferase levels, and higher MR-proADM levels.

ANAESTHESIOLOGY INTENSIVE THERAPY (2022)

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Letter Cardiac & Cardiovascular Systems

Myocardial injury: a future challenge for long-COVID-19 complications

Lukasz Szarpak et al.

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES (2021)

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Article Medical Laboratory Technology

The vasoactive peptide MR-pro-adrenomedullin in COVID-19 patients: an observational study

Claudia Gregoriano et al.

Summary: The study showed a close association between admission MR-proADM levels and in-hospital mortality in COVID-19 patients, with good predictive capability. An admission MR-proADM threshold of 0.93 nmol/L was found to best predict in-hospital mortality, playing an important role in risk stratification and ruling out fatal outcomes for COVID-19 patients.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

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Letter Cardiac & Cardiovascular Systems

Heart inflammation risk after COVID-19 vaccine

Lukasz Szarpak et al.

CARDIOLOGY JOURNAL (2021)

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Article Infectious Diseases

Circulating MR-proADM levels, as an indicator of endothelial dysfunction, for early risk stratification of mid-term mortality in COVID-19 patients

Luis Garcia de Guadiana-Romualdo et al.

Summary: MR-proADM plays a role in the mid-term prognosis of COVID-19 patients and may assist physicians with risk stratification. The study found that MR-proADM levels were an independent predictor of 90-day mortality in COVID-19 patients.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

MR-proADM as marker of endotheliitis predicts COVID-19 severity

Luis Garcia de Guadiana-Romualdo et al.

Summary: This study investigated the relationship between circulating mid-regional proadrenomedullin (MR-proADM) levels and the prognosis of COVID-19 patients, and found that MR-proADM was the best predictor for death and disease progression in these patients.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Letter Cardiac & Cardiovascular Systems

D-dimer levels predict COVID-19 severity and mortality

Kurt Ruetzler et al.

KARDIOLOGIA POLSKA (2021)

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Article Multidisciplinary Sciences

Effectiveness of mid-regional pro-adrenomedullin (MR-proADM) as prognostic marker in COVID-19 critically ill patients: An observational prospective study

Giorgia Montrucchio et al.

Summary: In COVID-19 ICU patients, MR-proADM consistently showed higher values in non-survivors and better predicted mortality compared to other biomarkers. Repeated measurements of MR-proADM may aid in rapid and effective decision-making, while further studies are needed to elucidate the mechanisms behind the increase in MR-proADM in COVID-19 patients.

PLOS ONE (2021)

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Article Virology

Mid-Regional Pro-Adrenomedullin, Methemoglobin and Carboxyhemoglobin as Prognosis Biomarkers in Critically Ill Patients with COVID-19: An Observational Prospective Study

Crhistian-Mario Oblitas et al.

Summary: In critically ill COVID-19 patients, elevated MR-proADM levels on admission were associated with a higher risk of 30-day mortality and poor outcomes. MetHb and COHb levels were not found to be associated with prognosis in this study.

VIRUSES-BASEL (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Making things right! Shouldn't we screen patients with thromboembolic events for SARS-CoV-2 infection, during the pandemia?

C. de Roquetaillade et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Pediatrics

Biomarkers in COVID-19: An Up-To-Date Review

Madhusudan Samprathi et al.

Summary: Biomarkers play a crucial role in the COVID-19 pandemic, providing important information for clinical diagnosis and treatment. Different categories of biomarkers offer valuable insights, but there is still a lack of definitive answers on which biomarkers to evaluate when and in whom, and how best to utilize this information.

FRONTIERS IN PEDIATRICS (2021)

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Article

Retrospective evaluation of laboratory findings of suspected paediatric COVID-19 patients with positive and negative RT-PCR

Eda Yaman et al.

Disaster and Emergency Medicine Journal (2021)

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Article Critical Care Medicine

Endothelium-associated biomarkers mid-regional proadrenomedullin and C-terminal proendothelin-1 have good ability to predict 28-day mortality in critically ill patients with SARS-CoV-2 pneumonia: A prospective cohort study

Jos A. H. van Oers et al.

Summary: The study assessed the ability of MR-proADM and CT-proET-1 to predict 28-day mortality in critically ill patients with SARS-CoV-2 pneumonia. Both biomarkers showed good predictive ability for mortality at baseline and over time, with high accuracy in identifying non-survivors.

JOURNAL OF CRITICAL CARE (2021)

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Article Urology & Nephrology

Kidney Outcomes in Long COVID

Benjamin Bowe et al.

Summary: The study showed that survivors of COVID-19 had an increased risk of kidney outcomes in the post-acute phase of the disease, indicating the importance of paying attention to kidney disease in long-term COVID-19 care.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Medical Laboratory Technology

The vasoactive peptide MR-pro-adrenomedullin in COVID-19 patients: an observational study

Claudia Gregoriano et al.

Summary: Elevated levels of MR-proADM on admission and during hospital stay are independently associated with in-hospital mortality in COVID-19 patients, allowing for better risk stratification and the potential to rule out fatal outcomes.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

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Article Medicine, General & Internal