☆ 4.6 Review

Using chronobiology-based second-generation artificial intelligence digital system for overcoming antimicrobial drug resistance in chronic infections

ANNALS OF MEDICINE (2023)

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Microtubules as a potential platform for energy transfer in biological systems: a target for implementing individualized, dynamic variability patterns to improve organ function

Yaron Ilan

Summary: This paper reviews the important role of microtubules in cellular function, as well as their dynamic instability and energy transfer functions. It demonstrates that targeting microtubules can improve cell plasticity and organ function, and potentially control quantum effects in biological systems. This finding is significant for the development of microtubule-targeting drug therapies and personalized medicine.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2023)

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Review Cell Biology

Circadian rhythms in infectious diseases and symbiosis

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Summary: Many organisms have evolved timekeeping mechanisms to optimize cellular functions and anticipate environmental changes. Recent research has focused on the interactions between hosts and microbes, with a specific emphasis on how circadian clocks modulate these interactions.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

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Article Environmental Sciences

A Subject-Tailored Variability-Based Platform for Overcoming the Plateau Effect in Sports Training: A Narrative Review

Ram Gelman et al.

Summary: The plateau effect in training is a significant obstacle that affects both professional athletes and average individuals. The lack of continuous improvement in muscle-nerve-axis performance and cardiorespiratory parameters is due to compensatory adaptation mechanisms. Overcoming this plateau has proven to be only partially successful, and it remains a significant unmet need for individuals with chronic neuromuscular, cardiopulmonary, and metabolic diseases. This review discusses the obstacles in overcoming the training plateau and proposes implementing subject-tailored variability patterns to prevent and overcome this plateau in muscle and cardiorespiratory performance.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Review Microbiology

Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

Sahaya Nadar et al.

Summary: This review discusses the formation of biofilms and the strategies and mechanisms of antibiofilm agents. It emphasizes the importance of using multiple approaches and combination therapy to enhance the control and management of biofilms.

MICROORGANISMS (2022)

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Review Medicine, General & Internal

Digital Medical Cannabis as Market Differentiator: Second-Generation Artificial Intelligence Systems to Improve Response

Yaron Ilan

Summary: The legalization of cannabis products and the interest in their therapeutic benefits have created new opportunities for therapy and marketing. However, the variability in formulations, administration modes, therapeutic regimens, and patient responses make it difficult to standardize medical cannabis-based treatments. Digital medical cannabis, controlled by second-generation AI systems, aims to improve patient responses and address tolerance and variability issues. It offers potential benefits for standardization, therapeutic efficacy, cost reduction, and revenue increase.

FRONTIERS IN MEDICINE (2022)

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Review Infectious Diseases

Genetic susceptibility to viral disease in humans

Trine H. Mogensen

Summary: This article reviews the major IEIs predisposing to severe or chronic viral infections, discussing the clinical implications for individualized prophylaxis and treatment. Insights into genetic predisposition to viral infections in humans, with a focus on defects related to innate immune responses, are provided.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Review Infectious Diseases

The circadian rhythm of viruses and its implications on susceptibility to infection

Jose-Ramon Blanco et al.

Summary: Circadian genes have an impact on hormonal, metabolic, and immunological pathways and are implicated in some infectious diseases. Understanding the mechanisms linking circadian rhythms and viral infections is important for personalized precision medicine.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2022)

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Article Pharmacology & Pharmacy

Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology

Dory Rotnemer-Golinkin et al.

Summary: This feasibility study established a model to determine the personalized-inherent variability in a time-dependent response to immune triggers. The results demonstrate significant inter- and intrasubject variations in the timing and magnitude of immune response to triggers. These findings emphasize the importance of considering individualized time-dependent variability in immune responses when designing personalized-based immunotherapies.

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Review Clinical Neurology

Digital Analgesic Comprising a Second-Generation Digital Health System: Increasing Effectiveness by Optimizing the Dosing and Minimizing Side Effects

Henny Azmanov et al.

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JOURNAL OF PAIN RESEARCH (2022)

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Review Microbiology

Recent Strategies to Combat Biofilms Using Antimicrobial Agents and Therapeutic Approaches

Looniva Shrestha et al.

Summary: Biofilms are complex bacterial assemblages that cause chronic infections. The development of antibiofilm compounds has become crucial for the treatment of biofilm-associated infections.

PATHOGENS (2022)

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Review Health Care Sciences & Services

Next-Generation Personalized Medicine: Implementation of Variability Patterns for Overcoming Drug Resistance in Chronic Diseases

Yaron Ilan

Summary: Chronic diseases pose a significant challenge to healthcare, and non-responsiveness to chronic therapies is a major obstacle to their effectiveness. Variability in drug response is associated with the loss of drug effectiveness. This review proposes a three-phase platform for overcoming drug resistance, which includes introducing irregularity, developing a personalized pattern of irregularity, and implementing individualized genetic and proteomic-based methods to improve therapeutic efficacy.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article Biochemistry & Molecular Biology

The constrained disorder principle defines living organisms and provides a method for correcting disturbed biological systems

Yaron Ilan

Summary: The constrained disorder principle defines the existence and function of living organisms by specifying that biological systems operate within constrained random boundaries of disorder. This principle distinguishes living organisms from non-living organisms by the intrinsic disorder within personalized dynamic random boundaries. The constrained disorder is mandatory for the systems' existence and adaptability in continuously changing environments. It also determines the health and disease states by specifying the degree of disorder and the arbitrary boundaries of biological systems.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

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Review Health Care Sciences & Services

Ingestible electronic sensors to measure instantaneous medication adherence: A narrative review

Peter R. Chai et al.

Summary: Digital pill systems are a novel and direct method of measuring adherence, providing instantaneous adherence support. Research based on clinical trials and qualitative investigations has shown the potential of digital pill systems in measuring medication adherence and improving adherence.

DIGITAL HEALTH (2022)

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Article Clinical Neurology

The Importance of Sleep and Circadian Rhythms for Vaccination Success and Susceptibility to Viral Infections

Nina C. M. Schmitz et al.

Summary: Sleep and circadian rhythms are closely linked to the immune system and vaccination success. Lack of sleep and poor sleep quality can increase vulnerability, while sleep duration and timing may affect antibody response after vaccination. It is recommended to have at least 7 hours of sleep every night to reduce infection risk and optimize vaccine efficacy.

CLOCKS & SLEEP (2022)

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Review Biochemistry & Molecular Biology

Molecular regulations of circadian rhythm and implications for physiology and diseases

Francesca Fagiani et al.

Summary: Circadian rhythms are endogenous oscillations with a ca. 24-hour period associated with the earth's daily rotation and light/dark cycle. The circadian clock, consisting of transcription factors, not only generates rhythms but also controls physiological functions and intracellular pathways in tissues and organs. Disruption of circadian rhythms can impact human diseases and understanding this field represents a significant challenge in establishing precision medicine.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Endocrinology & Metabolism

Adropin as a potential mediator of the metabolic system-autonomic nervous system-chronobiology axis: Implementing a personalized signature-based platform for chronotherapy

Yotam Kolben et al.

Summary: Adropin, a peptide hormone, plays a significant role in energy homeostasis and metabolic regulation, influenced by circadian rhythms. The autonomic nervous system and circadian clocks are crucial in regulating metabolic pathways and energy balance, with chronotherapy showing beneficial effects in various systems. There is potential for adropin to act as a mediator in the metabolic system-autonomic nervous system axis, with personalized adropin and circadian rhythm-based platforms for chronotherapy being discussed for enhancing treatment efficacy.

OBESITY REVIEWS (2021)

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Review Cardiac & Cardiovascular Systems

Improving Diuretic Response in Heart Failure by Implementing a Patient-Tailored Variability and Chronotherapy-Guided Algorithm

Ariel Kenig et al.

Summary: Heart failure is a significant public health issue associated with high mortality and healthcare costs. The variability in response to diuretics and development of diuretic resistance have negative impacts on clinical outcomes. This review examines the mechanisms of diuretic resistance and discusses a novel model for overcoming it through personalized treatment strategies.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Short-Term Cohousing of Sick with Healthy or Treated Mice Alleviates the Inflammatory Response and Liver Damage

Yehudit Shabat et al.

Summary: The study found that cohousing sick mice with healthy or treated mice can alleviate liver damage in sick animals, reduce the incidence of immune-mediated hepatitis, and lower levels of liver damage-related biomarkers.

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Review Gastroenterology & Hepatology

Role of circadian rhythm and autonomic nervous system in liver function: a hypothetical basis for improving the management of hepatic encephalopathy

Yuval Ishay et al.

Summary: Hepatic encephalopathy is a common and debilitating complication of cirrhosis, affecting many patients despite the effectiveness of various therapies. The circadian rhythm plays a crucial role in liver functions, impacting liver pathology and metabolism. Utilizing circadian rhythm-based approaches could potentially enhance the efficacy of treatments for recurrent and persistent hepatic encephalopathy.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

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Article Biology

Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic

Shaon Sengupta et al.

Summary: This article reviews the interaction between circadian rhythms and viral infections, highlighting the importance of circadian clock in regulating viral replication and host responses. Future research directions are proposed to further explore the multifaceted role of circadian clock in viral infections.

JOURNAL OF BIOLOGICAL RHYTHMS (2021)

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Review Pharmacology & Pharmacy

Improving the long-term response to antidepressants by establishing an individualized platform based on variability and chronotherapy

Yuval Isahy et al.

Summary: This article discusses the mechanisms associated with the loss of response to antidepressants and the potential role of the autonomic nervous system and chronobiology in the pathogenesis and treatment response of depression. It introduces a novel treatment strategy based on individual variability and guided by chronotherapy regimens. The implementation of personalized algorithms is proposed to shed light on the mechanisms of TRD and improve long-term drug response.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS (2021)

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Article Environmental Sciences

Improving Global Healthcare and Reducing Costs Using Second-Generation Artificial Intelligence-Based Digital Pills: A Market Disruptor

Yaron Ilan

Summary: The digital pill, utilizing a second-generation AI system, improves patient response to drugs, reduces healthcare costs, and provides a market differentiator for branded and generic drug companies.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Review Endocrinology & Metabolism

Platform introducing individually tailored variability in nerve stimulations and dietary regimen to prevent weight regain following weight loss in patients with obesity

Tawfik Khoury et al.

Summary: Preventing weight regain following successful weight loss is a major challenge in obesity treatment, with long-term sustainability in weight loss still unresolved due to the body's compensatory adaptation mechanisms.

OBESITY RESEARCH & CLINICAL PRACTICE (2021)

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Review Immunology

Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis

Brittney D. Gimza et al.

Summary: Staphylococcus aureus is a common etiologic agent in osteomyelitis, a prevalent invasive disease. Treatment of this infection is challenging due to antimicrobial resistant strains, antibiotic tolerance in staphylococci, and bone remodeling and destruction.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Medicine, General & Internal

Duration of Bisphosphonate Drug Holidays in Osteoporosis Patients: A Narrative Review of the Evidence and Considerations for Decision-Making

Kaleen N. Hayes et al.

Summary: Bisphosphonates are the primary treatment for osteoporosis, and a drug holiday of two to three years is recommended for most patients after long-term use to reduce the risk of adverse events. Duration of bisphosphonate effects during the drug holiday and individual patient factors should be considered when determining the appropriate time to stop therapy.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Gastroenterology & Hepatology

Helicobacter pylori infection and antibiotic resistance - from biology to clinical implications

Evariste Tshibangu-Kabamba et al.

Summary: Helicobacter pylori is a major human pathogen with increasing antibiotic resistance posing a serious threat to human health. The resistance mechanisms include single drug resistance, multidrug resistance, and heteroresistance, primarily related to mutational changes and target-mediated mechanisms. Further research is needed to explore additional biological attributes driving drug resistance in H. pylori for better treatment outcomes.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Review Pharmacology & Pharmacy

Connected healthcare: Improving patient care using digital health technologies

Atheer Awad et al.

Summary: Digital technologies of Healthcare 4.0 are revolutionizing traditional healthcare models, with advancements in patient monitoring, personalized medicine, precision surgery, and medical logistics using drones. This review discusses the most promising healthcare technologies, their strengths, limitations, and opportunities for clinical adoption.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Medicine, Research & Experimental

A digital health platform for assisting the diagnosis and monitoring of COVID-19 progression: An adjuvant approach for augmenting the antiviral response and mitigating the immune-mediated target organ damage

Yuval Ishay et al.

Summary: The COVID-19 pandemic has posed challenges for clinicians in diagnosis and treatment, with studies showing immune dysregulation as a key factor. A new platform has been introduced for sharing information on diagnosis and monitoring of patients with COVID-19, along with an approach to enhance antiviral immune response.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

Establishing a second-generation artificial intelligence-based system for improving diagnosis, treatment, and monitoring of patients with rare diseases

Noa Hurvitz et al.

Summary: Patients with rare diseases face challenges such as late diagnosis, lack of proper response to therapies, and absence of valid monitoring tools. First-generation AI algorithms are limited by the shortage of big data resources, hindering their usefulness for patients and physicians.

EUROPEAN JOURNAL OF HUMAN GENETICS (2021)

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Article Oncology

Drug Holidays and Overall Survival of Patients with Metastatic Colorectal Cancer

Silvio Ken Garattini et al.

Summary: The study suggests that drug holidays (DHs) during treatment of metastatic colorectal cancer may provide longer overall survival, while different de-escalation strategies help reduce toxicity and ensure quality of life.

CANCERS (2021)

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Article Surgery

Long-term survival achieved by repeated administration of ramucirumab after drug holidays due to proteinuria in recurrent gastric cancer

Naoyuki Uehata et al.

Summary: RAM has been proven effective against unresectable or recurrent gastric cancer, but its administration is often discontinued due to adverse events. This case report highlights the successful long-term survival achieved by a patient with recurrent gastric cancer through repeated RAM administration following long-term drug holidays due to proteinuria.

SURGICAL CASE REPORTS (2021)

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Review Biology

The Circadian Clock and Viral Infections

Helene Borrmann et al.

Summary: The circadian clock is crucial for regulating virus infections and host responses, providing opportunities for novel antiviral therapies.

JOURNAL OF BIOLOGICAL RHYTHMS (2021)

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Article Medicine, General & Internal

Treatment of Highly Drug-Resistant Pulmonary Tuberculosis

Francesca Conradie et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Cell Biology

Order Through Disorder: The Characteristic Variability of Systems

Yaron Ilan

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Immunology

For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases

Aissatou Bailo Diallo et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

Introducing variability in targeting the microtubules: Review of current mechanisms and future directions in colchicine therapy

Esther Forkosh et al.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2020)

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Review Clinical Neurology

The role of chronobiology in drug-resistance epilepsy: The potential use of a variability and chronotherapy-based individualized platform for improving the response to anti-seizure drugs

Assaf Potruch et al.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2020)

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Review Gastroenterology & Hepatology

T-Cell Immunity in Pancreatic Cancer

Reham Ajina et al.

PANCREAS (2020)

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Review Medicine, Research & Experimental

Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects

Yaron Ilan

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

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Article Health Care Sciences & Services

Second-Generation Digital Health Platforms: Placing the Patient at the Center and Focusing on Clinical Outcomes

Yaron Ilan

FRONTIERS IN DIGITAL HEALTH (2020)

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Advanced Tailored Randomness: A Novel Approach for Improving the Efficacy of Biological Systems

Yaron Ilan

JOURNAL OF COMPUTATIONAL BIOLOGY (2020)

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Review Immunology

Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming resistance to antiviral agents

Ram Gelman et al.

EMERGING MICROBES & INFECTIONS (2020)

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Article Immunology

Drug-free Holidays: Compliance, Tolerability, and Acceptability of a 3-Day Atovaquone/Proguanil Schedule for Pretravel Malaria Chemoprophylaxis in Australian Travelers

Colleen L. Lau et al.

CLINICAL INFECTIOUS DISEASES (2019)

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Review Medicine, Research & Experimental

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JOURNAL OF TRANSLATIONAL MEDICINE (2019)

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Review Medicine, General & Internal

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LANCET (2019)

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ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2019)

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Review Cell Biology

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Yaron Ilan

CELL BIOLOGY INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

The role of microtubules in the immune system and as potential targets for gut-based immunotherapy

Tahel Ilan-Ber et al.

MOLECULAR IMMUNOLOGY (2019)

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Review Immunology

β-Glycosphingolipids as Mediators of Both Inflammation and Immune Tolerance: A Manifestation of Randomness in Biological Systems

Yaron Ilan

FRONTIERS IN IMMUNOLOGY (2019)

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CURRENT OPINION IN MICROBIOLOGY (2019)

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Personalized inherent randomness of the immune system is manifested by an individualized response to immune triggers and immunomodulatory therapies: a novel platform for designing personalized immunotherapies

Madi El-Haj et al.

IMMUNOLOGIC RESEARCH (2019)

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Overcoming randomness does not rule out the importance of inherent randomness for functionality

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JOURNAL OF BIOSCIENCES (2019)

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Letter Endocrinology & Metabolism

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OSTEOPOROSIS INTERNATIONAL (2019)

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Review Immunology

Introducing Patterns of Variability for Overcoming Compensatory Adaptation of the Immune System to Immunomodulatory Agents: A Novel Method for Improving Clinical Response to Anti-TNF Therapies

Tawfik Khoury et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Microtubules: From understanding their dynamics to using them as potential therapeutic targets

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JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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A Personalized Signature and Chronotherapy-Based Platform for Improving the Efficacy of Sepsis Treatment

Ariel Kenig et al.

FRONTIERS IN PHYSIOLOGY (2019)

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Review Gastroenterology & Hepatology

Why targeting the microbiome is not so successful: can randomness overcome the adaptation that occurs following gut manipulation?

Yaron Ilan

CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY (2019)

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Letter Clinical Neurology

Intermittent drug holidays in fingolimod therapy for multiple sclerosis

Masami Tanaka et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

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Letter Clinical Neurology

Intermittent drug holidays in fingolimod therapy for multiple sclerosis

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MULTIPLE SCLEROSIS JOURNAL (2018)

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Article Pharmacology & Pharmacy

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ANTIVIRAL RESEARCH (2018)

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CRITICAL CARE (2018)

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Digital adherence technologies for the management of tuberculosis therapy: mapping the landscape and research priorities

Ramnath Subbaraman et al.

BMJ GLOBAL HEALTH (2018)

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Review Microbiology

An overview of the antimicrobial resistance mechanisms of bacteria

Wanda C. Reygaert

AIMS MICROBIOLOGY (2018)

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Review Medicine, General & Internal

Role of Chronobiology as a Transdisciplinary Field of Research: Its Applications in Treating Mood Disorders

Okan Caliyurt

BALKAN MEDICAL JOURNAL (2017)

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Article Environmental Sciences

Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis

Xiaoqiu Liu et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2017)

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Review Immunology

Coinhibitory Receptor expression and immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic viral infections and Cancer

Isobel S. Okoye et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Mobile health treatment support intervention for HIV and tuberculosis in Mozambique: Perspectives of patients and healthcare workers

Jose Antonio Nhavoto et al.

PLOS ONE (2017)

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Review Infectious Diseases

Antibiotic resistance in Helicobacter pylori

Claudio Alba et al.

CURRENT OPINION IN INFECTIOUS DISEASES (2017)

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Article Pharmacology & Pharmacy

A Mathematical Model to Predict HIV Virological Failure and Elucidate the Role of Lymph Node Drug Penetration

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CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2017)

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Article Genetics & Heredity

Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging

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GENETICS (2016)

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Article Infectious Diseases

Enhancing management of tuberculosis treatment with video directly observed therapy in New York City

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INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2016)

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Editorial Material Biotechnology & Applied Microbiology

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NATURE BIOTECHNOLOGY (2016)

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Prospective single-arm interventional pilot study to assess a smartphone-based system for measuring and supporting adherence to medication

James S. Molton et al.

BMJ OPEN (2016)

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Article Genetics & Heredity

Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging

Daniel Nichol et al.

GENETICS (2016)

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Article Public, Environmental & Occupational Health

Feasibility of Real Time Medication Monitoring Among HIV Infected and TB Patients in a Resource-Limited Setting

I. Marion de Sumari-de Boer et al.

AIDS AND BEHAVIOR (2016)

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Article Infectious Diseases

Feasibility of tuberculosis treatment monitoring by video directly observed therapy: a binational pilot study

R. S. Garfein et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2015)

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Article Multidisciplinary Sciences

A new antibiotic kills pathogens without detectable resistance

Losee L. Ling et al.

NATURE (2015)

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Article Medicine, General & Internal

Effectiveness of Electronic Reminders to Improve Medication Adherence in Tuberculosis Patients: A Cluster-Randomised Trial

Xiaoqiu Liu et al.

PLOS MEDICINE (2015)

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Drug Holidays From ADHD Medication: International Experience Over the Past Four Decades

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JOURNAL OF ATTENTION DISORDERS (2015)

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SMS reminders to improve the tuberculosis cure rate in developing countries (TB-SMS Cameroon): a protocol of a randomised control study

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Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes

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Correlative Time-Resolved Fluorescence Microscopy To Assess Antibiotic Diffusion-Reaction in Biofilms

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Article Multidisciplinary Sciences

Assessing the impact of adherence to anti-retroviral therapy on treatment failure and resistance evolution in HIV

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Bacteriology and Antibiotic Resistance in Chronic Rhinosinusitis

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Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders

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AIDS (2011)

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Origins and Evolution of Antibiotic Resistance

Julian Davies et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2010)

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Article Biochemistry & Molecular Biology

ARDB-Antibiotic Resistance Genes Database

Bo Liu et al.

NUCLEIC ACIDS RESEARCH (2009)

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Review Pharmacology & Pharmacy

Chronobiology and chronotoxicology of antibiotics and aminoglycosides

Denis Beauchamp et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

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Article Microbiology

Use of confocal microscopy to analyze the rate of vancomycin penetration through Staphylococcus aureus biofilms

KK Jefferson et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)

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Review Gastroenterology & Hepatology

H pylori antibiotic resistance:: prevalence, importance, and advances in testing

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