期刊
ANNALS OF HEMATOLOGY
卷 102, 期 1, 页码 89-97出版社
SPRINGER
DOI: 10.1007/s00277-022-05061-w
关键词
Cytogenetic evolution; Acute myeloid leukemia; Allogeneic hematopoietic stem cell transplantation; Relapse; Prognosis
类别
This study analyzed 34 AML patients who relapsed after allo-HSCT and found that cytogenetic evolution (CGE) had a significant impact on the prognosis, with more complex cytogenetic characteristics in the CGE group. The 6-month post-relapse overall survival was significantly lower in the CGE group. Other factors such as the occurrence of chronic graft-versus-host disease and conditioning regimen were also associated with the prognosis.
Acute myeloid leukemia (AML) patients relapsing after allogeneic hematopoietic stem cell transplantation (allo-HSCT) have a poor prognosis. Cytogenetic evolution (CGE) has been investigated and found to have an important impact on the prognosis of relapsed leukemia, but its impact on AML patients relapsing after transplantation remains controversial. In this study, we analyzed 34 AML patients relapsing after allo-HSCT, among whom 14 developed additional abnormalities in chromosomal karyotype after leukemia recurrence (CGE group) and 20 patients did not (non-CGE group). We found that the cytogenetic characteristics were much more complex at relapse in the CGE group, and the acquisition of aberrations at relapse most commonly involved chromosome 11. The 6-month post-relapse overall survival (PROS) of the CGE group was significantly lower than that of the non-CGE group (21.4% versus 50.0%, P = 0.004). The CGE group also showed a trend of worse 2-year OS (7.1% versus 28.6%, P = 0.096). In the multivariate analyses, the occurrence of chronic graft-versus-host disease (HR 0.27 [95% CI, 0.11-0.68], P = 0.006) and a reduced-intensity FBA conditioning regimen (HR 0.42 [95% CI, 0.18-0.98], P = 0.045) were found to be two independent factors for a better PROS, whereas CGE (HR 3.16 [95% CI, 1.42-7.05], P = 0.005) was associated with a worse PROS. In conclusion, CGE was associated with a poor prognosis in AML patients who relapsed after allo-HSCT, and the importance of monitoring karyotype changes after transplantation should be noted.
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