4.5 Article

Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

HLA-matching with PTCy: a reanalysis of a CIBMTR dataset with propensity score matching and donor age

Alexander Ambinder et al.

Summary: This study compares the outcomes of blood or marrow transplantation using haploidentical donors and HLA-matched donors with different prophylactic methods. The results suggest that there is no significant difference in overall survival, disease-free survival, relapse rate, and nonrelapse mortality between the two groups. The impact of HLA matching on transplant outcomes with posttransplant cyclophosphamide may be less meaningful than previously reported.

BLOOD ADVANCES (2022)

Article Oncology

Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia

Charles Craddock et al.

Summary: The intensified RIC conditioning regimen, FLAMSA-Bu, did not improve outcomes for adults undergoing transplantation for high-risk AML or MDS, regardless of pretransplant MRD status. Pretransplant detectable MRD was associated with disease relapse, but acquisition of full donor T-cell chimerism improved overall survival.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Hematology

Impaired T- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide

Benedetta Rambaldi et al.

Summary: Administration of posttransplant cyclophosphamide has increased the number of patients undergoing HLA-haploidentical hematopoietic cell transplantation. Immune reconstitution in haplo-HCT patients showed delayed T-cell recovery skewed towards effector memory T cells and higher regulatory T cell ratios early after transplant. NK cell reconstitution also differed, with increased immature NK cells and enrichment of specific NK cell metadusters after haplo-HCT.

BLOOD ADVANCES (2021)

Article Hematology

A phase 2 trial of GVHD prophylaxis with PTCy, sirolimus, and MMF after peripheral blood haploidentical transplantation

Nelli Bejanyan et al.

Summary: The study demonstrates that GVHD prophylaxis with sirolimus/MMF following PTCy effectively prevents grade II-IV aGVHD after PB haplo-HCT, highlighting the need for a prospective comparison of sirolimus vs tacrolimus in combination with MMF for GVHD prophylaxis after PB HCT.

BLOOD ADVANCES (2021)

Article Hematology

HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis

Mahasweta Gooptu et al.

Summary: After comparing outcomes of 2036 haploidentical and 284 matched unrelated donor (MUD) transplantations with posttransplant cyclophosphamide (PTCy) graft-versus-host disease (GVHD) prophylaxis, it was found that MUD transplants had lower acute GVHD and nonrelapse mortality rates, as well as higher disease-free and overall survival, especially in recipients of reduced-intensity regimens. However, no significant differences were observed in patients receiving myeloablative conditioning regimens, highlighting the importance of donor-recipient HLA matching for allogeneic transplantation.
Article Hematology

Standardizing Definitions of Hematopoietic Recovery, Graft Rejection, Graft Failure, Poor Graft Function, and Donor Chimerism in Allogeneic Hematopoietic Cell Transplantation: A Report on Behalf of the American Society for Transplantation and Cellular Therapy

Mohamed A. Kharfan-Dabaja et al.

Summary: Allogeneic hematopoietic cell transplantation (allo-HCT) has made significant advances in recent years, broadening its indications and improving outcomes. Despite achieving consensus on certain definitions, challenges remain, such as the lack of agreement on delayed engraftment.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

Article Hematology

Myeloablative versus Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndromes-Long-Term Follow-Up of the BMT CTN 0901 Clinical Trial

Bart L. Scott et al.

Summary: This study provides long-term follow-up results of a randomized comparison of myeloablative conditioning (MAC) and reduced-intensity conditioning (MC) before allogeneic hematopoietic cell transplantation (HCT) for acute myelogenous leukemia (AML) or myelodysplasia (MDS). The findings suggest that while MAC patients had higher transplant-related mortality (TRM), they had significantly better overall survival compared to RIC patients. The study highlights the importance of conditioning intensity in determining outcomes post-HCT for AML and MDS patients.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

Article Oncology

Post-transplantation cyclophosphamide versus antithymocyte globulin in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation from HLA-identical sibling donors: A retrospective analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Giorgia Battipaglia et al.

Summary: GVHD is a major complication after allo-HSCT. Adding ATG or PTCY to standard immunosuppressive agents can reduce GVHD in different donor settings. Comparing outcomes of AML patients undergoing allo-HSCT from HLA-identical sibling donors with PTCY or ATG, it was found that while the overall outcomes were similar, ATG may be associated with lower incidence of chronic GVHD.

CANCER (2021)

Review Immunology

T cell regeneration after immunological injury

Enrico Velardi et al.

Summary: This article discusses the importance of immune reconstitution, specifically of T cells, following periods of haematopoietic cell stress. Delayed or defective recovery of T cells can have significant clinical consequences, highlighting the need for therapeutic strategies to restore immune function.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Oncology

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD

Bruce R. Blazar et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)