期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 88, 期 2, 页码 152-164出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2016-314411
关键词
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资金
- National Institutes of Health [NIH-AG046374, K01 AG049152]
- Larry J Hilbom Foundation
- Research Council of Norway [213837, 225989, 223273, 237250/EU JPND]
- South East Norway Health Authority [2013-123]
- Norwegian Health Association
- KG Jebsen Foundation
- National Alzheimer's Coordinating Center
- ASNR Foundation
- NIH/NIDA [U24DA041123]
- Alzheimer's Society [284]
- Alzheimers Research UK [ART-PG2011-20, ARUK-PhD2014-16] Funding Source: researchfish
- Medical Research Council [G0502157, G0400074, MR/M008525/1, MC_U123160657, G1100643, G0600724, MR/M023664/1, MC_UU_00005/12, MC_UU_00024/9, G0301152, G0700943, MC_U123160651, MC_U105597119, G1100540, MR/M501724/1, G0900652, MR/J009482/1] Funding Source: researchfish
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/C013102/1] Funding Source: researchfish
- National Institute for Health Research [CL-2012-18-010, NF-SI-0512-10033] Funding Source: researchfish
- Parkinson's UK [K-1501] Funding Source: researchfish
- Wellcome Trust [103838/Z/14/Z] Funding Source: researchfish
- MRC [G0301152, MR/M023664/1, G0700943, MC_UU_00024/9, MC_U123160651, G1100540, G0400074, G0502157, MC_U105597119, MR/M008525/1, MC_UU_00005/12, MR/J009482/1, G0900652, MC_U123160657, G0600724] Funding Source: UKRI
Background Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders is still not well understood. Here we evaluated genetic overlap between FTD, AD and PD to assess shared pathobiology and identify novel genetic variants associated with increased risk for FTD. Methods Summary statistics were obtained from the International FTD Genomics Consortium, International PD Genetics Consortium and International Genomics of AD Project (n>75 000 cases and controls). We used conjunction false discovery rate (FDR) to evaluate genetic pleiotropy and conditional FDR to identify novel FTD-associated SNPs. Relevant variants were further evaluated for expression quantitative loci. Results We observed SNPs within the HLA, MAPT and APOE regions jointly contributing to increased risk for FTD and AD or PD. By conditioning on polymorphisms associated with PD and AD, we found 11 loci associated with increased risk for FTD. Meta-analysis across two independent FTD cohorts revealed a genome-wide signal within the APOE region (rs6857, 30-UTR=PVRL2, p=2.21x10(-12)), and a suggestive signal for rs1358071 within the MAPT region (intronic=CRHR1, p=4.91x10(-7)) with the effect allele tagging the H1 haplotype. Pleiotropic SNPs at the HLA and MAPT loci associated with expression changes in cis-genes supporting involvement of intracellular vesicular trafficking, immune response and endo/lysosomal processes. Conclusions Our findings demonstrate genetic pleiotropy in these neurodegenerative diseases and indicate that sporadic FTD is a polygenic disorder where multiple pleiotropic loci with small effects contribute to increased disease risk.
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