期刊
ANIMAL CELLS AND SYSTEMS
卷 26, 期 6, 页码 338-347出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/19768354.2022.2141316
关键词
Breed-specific SNPs; breed-informative; genomic characteristics; native pigs; whole genome sequencing
资金
- Ministry of Education of the Republic of Korea
- National Research Foundation of Korea [NRF-2022R1A2C4002510]
- Cooperative Research Program for Agriculture Science & Technology Development, Rural Development Administration, Republic of Korea [PJ01620403]
Although conserving native pig breeds is important in Korea, there is limited research on the genomic aspects of identifying breed-specific variations. This study used whole genome sequencing data to identify breed-specific SNPs in native pig breeds, aiming to understand their unique characteristics, such as meat quality and disease resistance. Gene ontology analysis revealed specific biological processes associated with breed-specific SNPs, providing insights into the reasons behind the unique characteristics of native pig breeds.
Although conserving native pig breeds is important in Korea, research on the genomic aspects to identify breed-specific variations in native pig breeds is uncommon. Single nucleotide polymorphisms (SNPs) can be a powerful source for identifying breed-specific variants. We used whole genome sequencing data, including Jeju Native Pig (JNP), Korean Native Pig (KNP), Korean Wild Boar (KWB), and other western commercial pig breeds to determine native pig breed-specific SNPs. Furthermore, the goal was not only to determine the genomic specificity of native pig breeds but also to identify SNPs that carry breed-specific information (breed-informative SNPs) that can be related to breed characteristics. The representative characteristics of native pigs are their unique meat quality and disease resistance. We surveyed the gene ontology (GO) of native pigs with breed-specific SNPs. Examining the genes associated with GO may contribute to revealing the reasons for the unique characteristics of native pig breeds. The enriched GOs terms were neuron projection development, cell surface receptor signaling pathway, ion homeostasis in JNP, cell adhesion and wound healing in KNP, and DNA repair and reproduction in KWB. We expect that this study of breed-specific SNPs will enable us to gain a deeper understanding of native pigs in Korea.
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