期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 87, 期 9, 页码 1000-1004出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2015-311321
关键词
ALZHEIMER'S DISEASE
资金
- Swedish Research Council
- Wolfson Foundation
- NIHR UCL/H Biomedical Research Centre and Queen Square Dementia BRU
- Alzheimer's Research UK
- Medical Research Centre
- Medical Research Council
- Motor Neurone Disease Association Lady Edith Wolfson Senior Clinical Fellowship
- Knut and Alice Wallenberg Foundation
- Frimurarestiftelsen
- Swedish State Support for Clinical Research
- Medical Research Council [MR/K01014X/1] Funding Source: researchfish
- Motor Neurone Disease Association [Turner/Jan13/944-795] Funding Source: researchfish
- MRC [MR/K01014X/1] Funding Source: UKRI
Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurodegenerative diseases. Yet the increasing complexity of molecular histopathology at the cellular level in neurodegenerative disorders frequently appears at odds with phenotyping based on clinically-directed, macroscopic regional brain involvement. While cross-disease comparisons can provide insights into the differential vulnerability of networks and neuronal populations, we focus here on what is known about selective vulnerability-related factors that might explain the differential phenotypic expressions of the same diseasein this case, typical and atypical forms of Alzheimer's disease. Whereas considerable progress has been made in this area, much is yet to be elucidated; further studies comparing different phenotypic variants aimed at identifying both vulnerability and resilience factors may provide valuable insights into disease pathogenesis, and suggest novel targets for therapy.
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