Tumor-Selective Activation of Toll-Like Receptor 7/8 Agonist Nano-Immunomodulator Generates Safe Anti-Tumor Immune Responses upon Systemic Administration

Article Chemistry, Multidisciplinary

Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors

Judith Stickdorn et al.

Summary: Specific immune responses are crucial for the development of effective tumor vaccines. A pH-responsive nanogel platform consisting of an antigen and an immune adjuvant can elicit strong immune responses and inhibit tumor growth.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Tumor-Microenvironment-Activatable Polymer Nano-Immunomodulator for Precision Cancer Photoimmunotherapy

Jing Liu et al.

Summary: This study reports a smart semiconducting polymer nano-immunomodulator that can achieve precise regulation of photodynamic immunotherapy for cancer in the acidic tumor microenvironment. The release of immunogenic factors and TLR7 agonist at the tumor site activates dendritic cells, leading to strong antitumor activities. Additionally, the nano-immunomodulator can directly eradicate tumors and induce immunogenic cancer cell death. This approach enhances systemic antitumor immune responses, resulting in inhibition of tumor growth and metastasis.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Imiquimod-gemcitabine nanoparticles harness immune cells to suppress breast cancer

Bijay Singh et al.

Summary: Monotherapy with a single chemotherapeutic regimen has faced challenges in terms of clinical efficacy, leading to the need for combination therapy. This study demonstrates the potential of a hyaluronic acid-based drug combination of gemcitabine with imiquimod to stimulate immune cells and suppress breast cancer growth.

BIOMATERIALS (2022)

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Article Chemistry, Multidisciplinary

A pH-/Enzyme-Responsive Nanoparticle Selectively Targets Endosomal Toll-like Receptors to Potentiate Robust Cancer Vaccination

Heming Xia et al.

Summary: This study reports a pH-/enzyme-responsive TLR7/8 agonist-conjugated nanovaccine (TNV) that intelligently responds to the endosomal environment and releases the TLR7/8 agonist precisely at the receptor site, resulting in effective immune activation.

NANO LETTERS (2022)

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Article Multidisciplinary Sciences

pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages

Leonard Kaps et al.

Summary: In this study, liver fibrosis progression was prevented by repolarizing M2-type macrophages towards a non-fibrotic phenotype using a pH-degradable nanogel carrier system. The nanogels efficiently delivered the drug alendronate to nonparenchymal cells of fibrotic livers, reprogramming profibrotic M2 into antifibrotic M1 macrophages and preventing liver fibrosis progression. This approach has potential implications for the treatment of diseases driven by M2-type macrophages, including cancer.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Engineering, Biomedical

In Situ Tumor Vaccination with Calcium-Linked Degradable Coacervate Nanocomplex Co-Delivering Photosensitizer and TLR7/8 Agonist to Trigger Effective Anti-Tumor Immune Responses

Yutong Liu et al.

Summary: This study reports a novel nanocomplex that can induce tumor antigen production, promote maturation of dendritic cells, and expansion of T cells through intratumoral injection and laser irradiation, showing potential for tumor suppression and therapeutic application in pre-operative and post-operative settings.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

An Intelligent Nanovehicle Armed with Multifunctional Navigation for Precise Delivery of Toll-Like Receptor 7/8 Agonist and Immunogenic Cell Death Amplifiers to Eliminate Solid Tumors and Trigger Durable Antitumor Immunity

Yanyun Hao et al.

Summary: Intelligent nanovehicles accurately deliver drugs to tumor cells and dendritic cells, reducing tumor burden through immunogenic cell death and generating long-term immune protection.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

Anne Huppertsberg et al.

Summary: pH-responsive nanogels were fabricated for safe delivery of TLR7/8-stimulating imidazoquinolines, showing a spatially controlled immunostimulatory activity in the spleen after intravenous injection, without causing systemic off-target inflammatory responses. This approach highlights the potential of pH-degradable nanogels as a promising platform for intravenous administration of small-molecular TLR7/8 agonists in immune therapeutic applications.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Immunology

Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells

Faezzah Baharom et al.

Summary: The study demonstrates that using a self-assembling nanoparticle vaccine and adjuvant can expand stem-like CD8(+) T cells, optimize anti-tumor immunity, and enhance the strength and effectiveness of the anti-tumor response.

NATURE IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary