☆ 4.8 Review

Recent Advances in Oral and Transdermal Protein Delivery Systems

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

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Review Chemistry, Multidisciplinary

Dendritic Mesoporous Nanoparticles: Structure, Synthesis and Properties

Chun Xu et al.

Summary: Dendritic mesoporous silica nanoparticles have attracted attention due to their wide applications, but the terminology used is ambiguous. This review provides a critical analysis of reported dendritic silica nanoparticles according to their structural classification, updating the understanding of their formation mechanisms and the control of structural parameters. The review also focuses on the applications of dendritic mesoporous nanoparticles in the biomedical field, offering new insights into the structure-property relationship.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Biochemical Research Methods

Chemo-Enzymatic PEGylation/POxylation of Murine Interleukin-4

Dorothee Haas et al.

Summary: This study utilized PEtOx as an alternative to PEG for genetically extending murine IL-4 and successfully achieving site-directed conjugation through enzymatic coupling. This method allows for C-terminal bioconjugation of IL-4, extending its serum half-life and maintaining its therapeutic potency.

BIOCONJUGATE CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

Intestinal permeation enhancers enable oral delivery of macromolecules up to 70 kDa in size

Katherine C. Fein et al.

Summary: Decades of research on oral peptide drugs have led to clinically successful formulations, often utilizing permeation enhancers to facilitate absorption in the intestines. This study examined the effects of two permeation enhancers on the transport of macromolecules of varying sizes, highlighting their potential to improve the absorption of proteins.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Review Instruments & Instrumentation

Influencing factors and drug application of iontophoresis in transdermal drug delivery: an overview of recent progress

Yu Wang et al.

Summary: The stratum corneum of skin poses a strong barrier to most molecules, limiting transdermal drug delivery. Iontophoresis technology has emerged as an effective method to enhance drug permeation through the skin, providing a more efficient, noninvasive, and patient-friendly approach while widening the scope of drugs for transdermal delivery.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Oral insulin delivery by epithelium microenvironment-adaptive nanoparticles

Jianbo Li et al.

Summary: This study presents a novel nanoparticle platform for oral drug delivery based on adaptation to the intestinal microenvironment, demonstrating efficient drug protection and rapid mucus penetration at the jejunal epithelial surface. The platform showed significant reductions in blood glucose levels after intrajejunal administration in both normal and diabetic rats, highlighting its potential for controlled drug delivery.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Dual-modified nanoparticles overcome sequential absorption barriers for oral insulin delivery

Ziyue Xi et al.

Summary: By constructing a functional nanoparticle with dual-modification, this study addressed the absorption barriers for oral insulin delivery, improving its bioavailability and hypoglycemic effect. The formulation demonstrates the potential of oral macromolecule delivery by overcoming multiple gastrointestinal barriers with a simple dual-modification strategy.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Biochemistry & Molecular Biology

Hyaluronic-Acid-Coated Chitosan Nanoparticles for Insulin Oral Delivery: Fabrication, Characterization, and Hypoglycemic Ability

Haishan Wu et al.

Summary: A nanoparticle delivery system has been developed for insulin oral delivery, which can protect insulin, enhance absorption, and exhibit hyperglycemic effects.

MACROMOLECULAR BIOSCIENCE (2022)

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Review Gastroenterology & Hepatology

Foundations of gastrointestinal-based drug delivery and future developments

Jacqueline N. Chu et al.

Summary: Gastrointestinal-based drug delivery is preferred for its convenience and improved patient adherence, but absorption of drugs is limited by unique characteristics of the gastrointestinal tract, particularly for biologics. Overcoming challenges and considering unique features of each gastrointestinal compartment are essential for successful drug formulation. Emerging technologies aim to address remaining obstacles in gastrointestinal-based drug delivery.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Review Microbiology

Microbiome-based therapeutics

Matthew T. Sorbara et al.

Summary: Microbiome-based therapeutics have the potential to reduce disease susceptibility and enhance disease resistance. This review discusses the major bacterial phyla associated with health benefits and explores various microbiome-based therapeutics, including fecal microbiota transplantation, bacterial consortia, engineered symbiotic bacteria, and diet and prebiotics. It also highlights the challenges in therapeutic development and regulatory hurdles for clinical trials and manufacturing.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Instruments & Instrumentation

A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects

Arvinder K. Dhalla et al.

Summary: Biotherapeutics are difficult to deliver orally, but our orally ingestible robotic pill (RP) has shown promising safety and reliability in clinical studies, potentially serving as a versatile and reliable oral drug delivery platform.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Review Medicine, Research & Experimental

Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies

Guanyu Chen et al.

Summary: Despite the promise of oral delivery, harsh gastrointestinal conditions and defensive barriers hinder the development of suitable oral systems for peptide and protein drugs. Designing effective oral delivery strategies remains a challenge in the pharmaceutical field.

THERANOSTICS (2022)

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Article Multidisciplinary Sciences

Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery

Wei Chen et al.

Summary: Oral drug administration remains the preferred route for patients and health care providers, but delivering macromolecules through this route is challenging. In this study, a delivery system combining physical and nonphysical drug delivery enhancement modes was developed and tested in a large animal model. Inspired by a thorny-headed intestinal worm, a dynamic omnidirectional mucoadhesive microneedle system was created, which showed prolonged fixation on the gastric mucosa. The incorporation of sodium N-[8-(2-hydroxybenzoyl)amino] caprylate along with semaglutide demonstrated enhanced absorption in swine, and a targeted capsule system was developed to deploy intact microneedle-containing systems, enabling drug delivery in a privileged region of the gastrointestinal tract.

SCIENCE ADVANCES (2022)

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Article Pharmacology & Pharmacy

Milk-derived exosomes exhibit versatile effects for improved oral drug delivery

Lei Wu et al.

Summary: Exosomes, as endogenous courier vesicles, have gained increasing attention as biomimetic drug delivery vehicles. In this study, insulin-loaded milk-derived exosomes were fabricated and demonstrated to exhibit superior hypoglycemic effects when orally administered, compared with subcutaneously injected insulin. Mechanism studies revealed the multi-functional properties of milk-derived exosomes, including active multi-targeting uptake, pH adaptation, signal pathway activation, and mucus penetration, which contribute to their excellent oral performance.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Engineering, Biomedical

Micro-ecology restoration of colonic inflammation by in-Situ oral delivery of antibody-laden hydrogel microcapsules

Bo Li et al.

Summary: In-situ oral delivery of therapeutic antibodies is a convenient approach for chronic inflammation treatment. By using microcapsules as oral carriers, antibodies can survive in the gastrointestinal tract and achieve the same therapeutic effect as intravenous injection. The alteration of intestinal microorganism abundance after oral antibody-laden microcapsules delivery suggests the restoration of intestinal microecology.

BIOACTIVE MATERIALS (2022)

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Article Biotechnology & Applied Microbiology

Monocytes engineered with iSNAP inhibit human B-lymphoma progression

Haohsiang Wu et al.

Summary: The CD47-SIRP alpha axis has been rewired to create iSNAP-M, which activates engineered monocytes to suppress tumor progression.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers

Soheil Haddadzadegan et al.

Summary: The oral administration of therapeutic peptides and proteins faces various barriers, which can be overcome by using lipid-based nanocarriers. These nanocarriers enhance the lipophilic character of the drugs and protect them from enzymatic degradation. They can penetrate mucus and absorption membranes, enabling systemic delivery of the therapeutic molecules. Lipid-based nanocarriers show promising stability and delivery efficacy.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Chemical Approaches to Synthetic Drug Delivery Systems for Systemic Applications

Daniel Braatz et al.

Summary: Poor water solubility and low bioavailability of active pharmaceutical ingredients (APIs) are major challenges in pharmaceutical drug development. Drug delivery remains a key challenge for both small-molecule drugs and biopharmaceuticals. This Review provides insights into the challenges and requirements for designing and translating new polymer-based delivery systems, with a focus on chemical approaches for systemic drug delivery.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Medicinal

On the Utility of Chemical Strategies to Improve Peptide Gut Stability

Thomas Kremsmayr et al.

Summary: The inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a major challenge in oral peptide drug development. This study systematically analyzed the gut stability of different peptides and discussed medicinal chemistry strategies to improve peptide gut stability. It was found that cyclotides were the only scaffold class that could resist gastrointestinal degradation, and site-specific alterations were effective in improving stability. The importance of standardized test conditions and defined protocols for cross-study comparison was also highlighted.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Biotechnology & Applied Microbiology

Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors

Alex Abramson et al.

Summary: The study presents an orally dosed liquid auto-injector capable of delivering up to 4-mg doses of a bioavailable drug with up to 80% absolute bioavailability and a maximum plasma drug concentration within 30 min after dosing. This new approach improves dosing efficiencies and pharmacokinetics significantly compared to previous injector capsules and other chemical permeation enhancement technologies.

NATURE BIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Acid-Resistant and Physiological pH-Responsive DNA Hydrogel Composed of A-Motif and i-Motif toward Oral Insulin Delivery

Yuwei Hu et al.

Summary: An acid-resistant DNA hydrogel stable at extremely low pH values (as low as 1.2) has been developed. The hydrogel is formed by rational design of adenine (A)-rich and cytosine (C)-rich oligonucleotides, which can cross-link into duplex and quadruplex structures at different pH ranges. Under physiological pH, the hydrogel dissociates into a solution state. This acid-resistant and pH-responsive hydrogel has potential applications in oral drug delivery to acidic environments. Insulin was successfully encapsulated and orally administered using this hydrogel in diabetic rats.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

Lamprey-Teeth-Inspired Oriented Antibacterial Sericin Microneedles for Infected Wound Healing Improvement

Yan Deng et al.

Summary: An oriented antibacterial sericin microneedle (OASM) was designed for improved wound healing. The microneedles, inspired by lamprey teeth, provide both penetration and directional traction. Sericin, derived from silkworm cocoons, improves skin repair via hair follicle regeneration and angiogenesis. Additionally, zinc oxide nanoparticles enhance the antibacterial properties of the microneedles, showing promising clinical translational potential.

NANO LETTERS (2022)

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Article Biotechnology & Applied Microbiology

Development of spirulina for the manufacture and oral delivery of protein therapeutics

Benjamin W. Jester et al.

Summary: This study reports the genetic engineering methods for stable, high-level expression of bioactive proteins in spirulina, an edible photosynthetic cyanobacterium. Spirulina, as a biomanufacturing platform, combines the safety of a food-based production host with the accessible genetic manipulation and high productivity of microbial platforms, making it an advantageous system for manufacturing orally delivered therapeutic proteins.

NATURE BIOTECHNOLOGY (2022)

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Article Multidisciplinary Sciences

Needleless administration of advanced therapies into the skin via the appendages using a hypobaric patch

Faiza Benaouda et al.

Summary: This study demonstrates a novel method for needleless delivery of advanced therapies using a skin patch. By opening the skin appendages with a hypobaric chamber, direct delivery of vaccine antigens and drug nanoparticles was achieved. The patch was shown to enhance immune response to vaccine antigens and effectively reduce rat paw swelling.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Multidisciplinary Sciences

Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy

Dongxiao Zhang et al.

Summary: In this study, researchers have successfully developed an oral delivery system using Spirulina platensis as a microcarrier to protect the whole small intestine from radiation-induced injury during radiotherapy. The system accumulates the drug effectively and provides superior radioprotection compared to free drug and enteric capsules, preventing radiation-induced intestinal injury without affecting tumor regression. It also has benefits on gut microbiota homeostasis and long-term safety.

NATURE COMMUNICATIONS (2022)

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Article Pharmacology & Pharmacy

The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery

Jingyi Li et al.

Summary: This study demonstrates that the upregulated intestinal transporter PCFT facilitates the uptake and intracellular trafficking of ligand-modified nanoparticles. In cells with low expression of PCFT, nanoparticles are predominantly degraded in lysosomes.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Pharmacology & Pharmacy

Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors

Yuling Mao et al.

Summary: This study demonstrates that utilizing the intestinal lymphatic pathway for oral drug delivery can improve bioavailability and awaken the immune response in the body and lesion microenvironment. Researchers designed a novel nanocarrier called yMSN for targeted delivery of therapeutic cancer vaccines and antitumor drugs. The yMSN simultaneously awakened innate and adaptive immune responses, resulting in excellent antitumor efficacy.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Engineering, Biomedical

Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria

Yale Yue et al.

Summary: Outer membrane vesicles (OMVs) produced in the intestine by ingested genetically engineered bacteria, which are fused with tumour antigens, can serve as effective oral tumour vaccines in mice. These OMVs can stimulate dendritic cell maturation, inhibit tumour growth, and generate long-term antitumour immunity.

NATURE BIOMEDICAL ENGINEERING (2022)

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Review Pharmacology & Pharmacy

Characterization and impact of peptide physicochemical properties on oral and subcutaneous delivery

Alisa Klepach et al.

Summary: Peptides are an emerging modality in the biopharmaceutical industry, with subcutaneous delivery being the main route, but oral delivery is also being developed. However, barrier biology in subcutaneous tissue or the gastrointestinal tract can limit absorption of peptides, so careful molecular design is needed to optimize their properties. This review highlights effective techniques for evaluating the physicochemical properties of peptides and discusses the use of in vitro models in subcutaneous and oral delivery.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Biochemistry & Molecular Biology

Bile acid-based advanced drug delivery systems, bilosomes and micelles as novel carriers for therapeutics

Mohadeseh Nemati et al.

Summary: Diabetes mellitus affects a large number of patients worldwide and requires new methods to improve treatment efficacy. The use of bile acid mixed micelles and bilosomes can enhance the effectiveness of antidiabetic drugs and contribute to the development of new drug delivery systems.

CELL BIOCHEMISTRY AND FUNCTION (2022)

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Review Chemistry, Multidisciplinary

Dissolvable polymer microneedles for drug delivery and diagnostics

Masood Ali et al.

Summary: This comprehensive review provides contemporary knowledge on the design approaches of dissolvable transdermal microneedles, the materials science facilitating these delivery systems, and the opportunities these advanced materials can provide to enhance clinical outcomes.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Pharmacology & Pharmacy

Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hybrid nanocomposite system

Sang Hoon Lee et al.

Summary: This study developed a pH-responsive folic acid-grafted organic/inorganic hybrid nanocomposite system for targeted oral delivery of therapeutic antibodies. The system showed favorable drug carrier properties and exhibited pH-dependent drug release, leading to effective treatment of ulcerative colitis.

ACTA PHARMACEUTICA SINICA B (2022)

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Review Pharmacology & Pharmacy

Safety Challenges and Application Strategies for the Use of Dendrimers in Medicine

Xiang Li et al.

Summary: Dendrimers have various applications in medicine, particularly in gene and drug delivery, but their inherent toxicity limits their use in biological systems. Biocompatible dendrimers have been developed to reduce toxicity and technologies can be utilized to modify their properties. More comprehensive research on the harmful effects of dendrimers is needed for further advancements in the field.

PHARMACEUTICS (2022)

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Article Chemistry, Multidisciplinary

Materials and Carriers Development for Glucose-Responsive Insulin

Yuejun Yao et al.

Summary: Insulin replacement therapy plays a crucial role in controlling blood glucose levels, but the challenges of multiple injections and hypoglycemia risk have led to the development of glucose-responsive insulin delivery systems as a promising solution.

ACCOUNTS OF MATERIALS RESEARCH (2022)

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Review Chemistry, Multidisciplinary

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Jiang Ouyang et al.

Summary: Traditional treatments like chemotherapy and surgery often have severe side effects and cause pain. The emergence of nanomedicines and minimally invasive therapies has brought hope to patients with malignant diseases. Minimally invasive nanomedicines combine the advantages of nanomedicines and minimally invasive therapies, effectively targeting pathological cells and minimizing side effects. This review provides a comprehensive overview of the research status and challenges of minimally invasive nanomedicines and their applications in various fields.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Medicine, Research & Experimental

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Fei Qu et al.

Summary: Skin diseases have a significant impact on patients' quality of life and the global economy. Advanced transdermal drug delivery strategies, such as nanocarrier and microneedle-based systems, offer efficient and targeted drug delivery with reduced side effects and improved functions.

THERANOSTICS (2022)

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Review Materials Science, Multidisciplinary

Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications

Pooyan Makvandi et al.

Summary: This review discusses the biomimetic design, fabrication methods, and medical applications of bioinspired microneedles (BMNs), highlighting their potential in drug delivery, regenerative medicine, and other fields, as well as the future opportunities and challenges in clinical translation.

MATTER (2022)

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Review Chemistry, Multidisciplinary

Rational Design of Nanogels for Overcoming the Biological Barriers in Various Administration Routes

Qing Zhao et al.

Summary: This review examines recent advances in the rational design and structural modulation of nanogels to improve drug delivery efficiency by incorporating functional moieties or domains that allow them to regulate their structure and properties to overcome biological barriers. Future perspectives on the precise and efficient therapeutic use of nanogel formulations are also presented in this review.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Ionic Liquids and Deep Eutectic Solvents for Enhanced Delivery of Antibodies in the Gastrointestinal Tract

Pavimol Angsantikul et al.

Summary: This study presents the use of a novel ionic liquid and deep eutectic solvent, choline and glycolate (CGLY), as a platform for gastrointestinal administration of therapeutic antibodies. CGLY enhances paracellular transport of TNF alpha antibody in vitro and reduces intestinal mucus viscosity, improving antibody delivery. In vivo results in rats demonstrate that CGLY effectively delivers TNF alpha antibody into the intestinal mucosa and systemic circulation, with good tolerability observed in repeated dose studies.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Instruments & Instrumentation

Enhancement of skin permeability with thermal ablation techniques: concept to commercial products

Rabinarayan Parhi et al.

Summary: Traditionally, the skin is seen as a protective barrier, but it is now recognized as a specialized organ for drug delivery. Thermal ablation techniques have been proven to be effective in improving drug bioavailability in transdermal drug delivery.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Design of a self-unfolding delivery concept for oral administration of macromolecules

Jacob R. Jorgensen et al.

Summary: This study introduces a concept of oral delivery device using elastomeric material to enhance absorption of peptides like insulin. The polydimethylsiloxane foil unfolds in the intestine to closely contact with the intestinal mucosa, increasing peptide absorption. The potential for development of commercially viable biocompatible devices for oral delivery of macromolecules is promising.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Chemistry, Multidisciplinary

Lipid Nanoparticle-mRNA Formulations for Therapeutic Applications

Chang Wang et al.

Summary: This article highlights the effectiveness of lipid nanoparticles in delivering mRNA and their applications in treating various diseases. It also focuses on the recent advances in designing and developing different classes of lipids and lipid derivatives, as well as research directions in mRNA engineering.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Review Pharmacology & Pharmacy

Formulation strategies to improve the efficacy of intestinal permeation enhancers

Sam Maher et al.

Summary: The use of chemical permeation enhancers shows promise in improving oral absorption of low permeability active agents like peptides, but overcoming physiological barriers to achieve significant increases in bioavailability remains a challenge in clinical settings.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Cardiac & Cardiovascular Systems

Radiofrequency ablation: technological trends, challenges, and opportunities

Mohammadali Habibi et al.

Summary: RF ablation has been utilized in the treatment of cardiac arrhythmias for over three decades, and with improvements in catheter designs and energy delivery, the procedure is now much safer and more efficient.

EUROPACE (2021)

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Article Chemistry, Physical

Microneedle-array patch with pH-sensitive formulation for glucose-responsive insulin delivery

Feng-Qin Luo et al.

Summary: The study presents a novel glucose-responsive insulin delivery system using pH-sensitive insulin-loaded nanoparticles and glucose oxidase-catalase-loaded pH-insensitive nanoparticles. This system effectively regulates blood glucose levels within normal ranges for a prolonged period and reduces inflammation risks towards normal skin.

NANO RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Revealing the importance of carrier-cargo association in delivery of insulin and lipidated insulin

Ragna Guldsmed Diedrichsen et al.

Summary: The study found that shuffle and penetramax are potential carriers for the transmucosal delivery of insulin upon oral administration, with their effects depending on the association with cargo and cell membrane. Interestingly, the enhancement of cargo permeation through the tight epithelium points towards the paracellular route, contrary to the expected belief of transcellular route facilitated by cell-penetrating capabilities.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Pharmacology & Pharmacy

Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

David Dahlgren et al.

Summary: Paracellular permeation enhancers were found to increase the mucosal permeability of hydrophilic peptides with low molecular mass compared to those with a transcellular mechanism-of-action. Additionally, luminal hypotonicity primarily affects paracellular solute transport in the mucosal crypt region.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Chemistry, Applied

The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: A review

Andreia Bagliotti Meneguin et al.

Summary: Polysaccharides, through nano- and microencapsulation, can protect orally administered insulin from the harsh conditions of the gastrointestinal tract and improve permeability through cellular pathways, offering advantages such as targeted delivery.

CARBOHYDRATE POLYMERS (2021)

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Review Chemistry, Multidisciplinary

The Chemical Synthesis of Insulin: An Enduring Challenge

John A. Karas et al.

Summary: This review article discusses the challenges and advancements in chemically synthesizing insulin, a peptide hormone essential for the treatment of diabetes. Various strategies have been developed to assemble the intricate structure of insulin, enabling its efficient production and leading to the creation of novel analogues with optimized features for industrial manufacture.

CHEMICAL REVIEWS (2021)

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Article Biotechnology & Applied Microbiology

Trends in peptide drug discovery

Markus Muttenthaler et al.

Summary: This Perspective summarizes key trends in peptide drug discovery and development, including human hormones, elegant medicinal chemistry and rational design strategies, peptide drugs derived from nature, and major breakthroughs in molecular biology and peptide chemistry. It also emphasizes lessons from earlier approaches that are still relevant today and discusses emerging strategies impact on peptide drug discovery.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Pharmacology & Pharmacy

Nanocarriers for oral delivery of biologics: small carriers for big payloads

Yuxue Cao et al.

Summary: Biologics, or macromolecular therapeutics of biological origin, have emerged as a rapidly growing class of drugs for the treatment of chronic and acute conditions. However, their administration via the parenteral route results in high cost, low patient compliance, and systemic toxicity, prompting researchers to focus on developing carriers for oral delivery. This review examines the challenges of oral biologics delivery, discusses conventional formulation strategies and their limitations, and explores the progress and limitations of using nanocarriers for oral delivery of biologics.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

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Article Immunology

Engineered Bacteria of MG1363-pMG36e-GLP-1 Attenuated Obesity-Induced by High Fat Diet in Mice

Lingfang Wang et al.

Summary: The genetically engineered bacteria secreting GLP-1 can effectively improve obesity by promoting fatty acid oxidation and increasing intestinal microbial diversity in obese mice induced by high fat diet.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Instruments & Instrumentation

A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin

Irene Santalices et al.

Summary: The study developed and characterized a novel nanoemulsion for oral delivery of hydrophobically modified insulin. The nanoemulsion showed good stability, miscibility, and mucodiffusive behavior in vitro, as well as high interaction and internalization in cell cultures. Additionally, it demonstrated a moderate hypoglycemic response in both healthy and diabetic rat models.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Materials Science, Multidisciplinary

Synthesis and characterization of PVP microneedle patch using metal bioelectrodes for novel drug delivery system

Su-Jin Yang et al.

Summary: This study developed a novel microneedle patch using metal bioelectrodes for enhanced drug delivery efficiency and biocompatibility. The metal-coated PVP microneedle patches show significant improvements in drug release efficiency and mechanical properties, making them suitable for cosmetic and medical applications.

MATERIALS & DESIGN (2021)

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Review Pharmacology & Pharmacy

Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

Ting Liu et al.

Summary: Microneedles play a crucial role in transdermal delivery of protein and peptide drugs, offering advantages over traditional injection methods and promising prospects in conventional therapies.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Nanoscience & Nanotechnology

Virus-Mimicking Mesoporous Silica Nanoparticles with an Electrically Neutral and Hydrophilic Surface to Improve the Oral Absorption of Insulin by Breaking Through Dual Barriers of the Mucus Layer and the Intestinal Epithelium

Yi Zhang et al.

Summary: The research team developed mesoporous silica nanoparticles mimicking virus surfaces to effectively penetrate the mucous layer and intestinal epithelium. These nanoparticles successfully loaded insulin to maintain its bioactivity under simulated intestinal conditions. In animal experiments, the nanoparticles reduced blood glucose levels in diabetic rats.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

The Current Status of MOF and COF Applications

Ralph Freund et al.

Summary: The amalgamation of different disciplines at the heart of reticular chemistry has broadened the boundaries of chemistry. Reticular design enables precise prediction of crystalline framework structures, tunability of chemical composition, and fine-tuning of material properties in metal-organic frameworks and covalent organic frameworks. Leveraging the unique properties of reticular materials has led to significant advances in both fundamental and applied research.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Oral delivery of antioxidant enzymes for effective treatment of inflammatory disease

Zhiying Zeng et al.

Summary: The approach of encapsulating native antiinflammatory proteins in wind chimes like cyclodextrin (WCC) for oral protein delivery is effective in enhancing stability and delivery efficiency. The integration of SOD and CAT in WCC nanovehicles shows synergistic effects in inhibiting inflammatory response, as demonstrated in a mouse colitis model.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Translational Applications of Hydrogels

Santiago Correa et al.

Summary: Advances in hydrogel technology have led to diverse applications in medicine and environmental engineering, providing solutions for various diseases and medical conditions. Collaboration across disciplines is essential for the development of contemporary hydrogels to accomplish complex biological tasks in different fields.

CHEMICAL REVIEWS (2021)

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Article Multidisciplinary Sciences

Orally deliverable strategy based on microalgal biomass for intestinal disease treatment

Danni Zhong et al.

Summary: The innovative strategy of oral drug delivery using a formulation based on Spirulina platensis loaded with curcumin shows promise for treating intestinal diseases. The formulation not only improves drug bioavailability but also demonstrates excellent antitumor and anti-inflammatory efficacy.

SCIENCE ADVANCES (2021)

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Review Pharmacology & Pharmacy

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Quangang Zhu et al.

Summary: Oral administration of proteins and peptides has been a big demand in clinical use, and research has focused on developing new technologies to overcome GI barriers, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, and intestinal microdevices. Some new technologies have been under clinical trials or even on the market.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Chemistry, Multidisciplinary

Shark Tooth-Inspired Microneedle Dressing for Intelligent Wound Management

Maoze Guo et al.

Summary: Intelligent wound management beyond therapeutic drug treatment shows potential in promoting recovery from chronic wounds. A shark tooth-inspired microneedle patch was developed using biomimetic structures for stable adhesion, controlled drug release, and analysis of inflammatory factors, as well as sensitive motion monitoring with MXene electronics, demonstrating improved recovery for full-thickness cutaneous wounds.

ACS NANO (2021)

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Article Engineering, Biomedical

Mucoadhesive versus mucopenetrating nanoparticles for oral delivery of insulin

Hongbo Cheng et al.

Summary: Mucoadhesive and mucopenetrating nanoparticles have different absorption mechanisms in enhancing oral insulin absorption. Mucopenetrating nanoparticles have a faster onset of action, while mucoadhesive nanoparticles show a sustained hypoglycemic effect. Overall, there is no significant difference in pharmacological availability between the two types of nanoparticles.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Microneedle-Mediated Vaccination: Innovation and Translation

Tao Sheng et al.

Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Protein Engineering Strategies for Improved Pharmacokinetics

Aurelie Rondon et al.

Summary: Protein therapeutics have become an important pillar in treating various diseases, but their clinical application is often hindered by issues such as short half-life and immunogenicity. Strategies to extend the half-life of proteins are being developed through polymer chemistry, protein engineering, and fusion to other proteins, with a focus on balancing between half-life extension and maintaining therapeutic activity.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Magneto-Responsive Microneedle Robots for Intestinal Macromolecule Delivery

Xiaoxuan Zhang et al.

Summary: The novel magneto-responsive microneedle robots are designed for efficient oral delivery of versatile macromolecules. With polarized magnetic substrate, the microneedle tips can target the small intestinal wall, insert into the tissue, and release encapsulated actives under specific magnetic fields, demonstrating practical values in oral delivery of insulin and blood glucose regulation.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A pH-Triggered Self-Unpacking Capsule Containing Zwitterionic Hydrogel-Coated MOF Nanoparticles for Efficient Oral Exendin-4 Delivery

Yuhao Zhou et al.

Summary: Oral delivery of peptides or proteins through a pH-triggered self-unpacking capsule can improve bioavailability by enhancing penetration in the gastrointestinal environment and intestinal mucosa. This strategy significantly increases plasma levels of exendin-4, boosts endogenous insulin secretion, and effectively lowers blood glucose levels.

ADVANCED MATERIALS (2021)

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Article Pharmacology & Pharmacy

Transient Permeation Enhancer® (TPE®) technology for oral delivery of octreotide: a technological evaluation

David J. Brayden et al.

Summary: The FDA approval of oral semaglutide for type 2 diabetes and oral octreotide for acromegaly demonstrates that selected niche peptides can be administered orally with the use of selected intestinal permeation enhancers. The oral octreotide formulation MYCAPSSA has shown promising results in terms of safety and efficacy, offering acromegaly patients a convenient alternative to monthly depot injections. The Transient Permeation Enhancer technology used in this formulation has shown potential in improving oral absorption of macromolecules.

EXPERT OPINION ON DRUG DELIVERY (2021)

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Article Materials Science, Multidisciplinary

Stimuli-responsive transdermal microneedle patches

Pooyan Makvandi et al.

Materials Today (2021)

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Review Endocrinology & Metabolism

One hundred years of insulin therapy

Chantal Mathieu et al.

Summary: Insulin, while not a cure for diabetes, has proven to be life-saving for type 1 diabetes patients and essential therapy for others with diabetes. Research on insulin analogues continues, with a focus on finding new treatments and potentially a true cure for diabetes.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Article Engineering, Biomedical

Modulation of Gastrointestinal Mucus Properties with Ionic Liquids for Drug Delivery

Kevin Peng et al.

Summary: Studies have shown that choline-based ionic liquids can significantly enhance the absorption of macromolecular drugs in the gastrointestinal tract by reducing drug interactions with mucus or disrupting the mucus layer, potentially improving the success rate of oral drug delivery.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Yeasts in nanotechnology-enabled oral vaccine and gene delivery

Elena Ivanova

Summary: Yeasts serve as excellent delivery vehicles for oral vaccines and gene therapies, enhancing resistance to the harsh gastrointestinal environment, facilitating mucosal passage, stimulating host immune responses, and potentially improving transfection rates.

BIOENGINEERED (2021)

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Article Materials Science, Multidisciplinary

Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes

Yufen Xiao et al.

Summary: An intelligent oral insulin platform has been developed using glucose-responsive polymeric nanoparticles to protect insulin integrity, overcome intestinal barriers, and release insulin based on blood glucose levels. This platform provides extended therapeutic effects and may reduce insulin administration frequency.

MATTER (2021)

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Article Engineering, Biomedical

Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin

Jung Seok Lee et al.

Summary: Orally delivered nanocarriers made from polymeric bile acid, carrying insulin or rapamycin, demonstrate metabolic and immunomodulatory functions in restoring blood-glucose levels, delaying the onset of diabetes, reversing inflammation, restoring metabolic functions, and extending animal survival. These ingestible bile-acid-polymer nanocarriers may offer translational opportunities for the prevention and treatment of type 1 diabetes.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Materials Science, Biomaterials

Insulin- and cholic acid-loaded zein/casein-dextran nanoparticles enhance the oral absorption and hypoglycemic effect of insulin

Xiaoyan Bao et al.

Summary: Insulin- and cholic acid-loaded zein nanoparticles with dextran surfaces were fabricated to enhance the oral absorptions of insulin in the intestine and in the liver. The dextran significantly increased the disperse stability of the nanoparticles, protected the loaded insulin from hydrolysis in digestive juices, and increased the permeability of the insulin.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Medicine, Research & Experimental

Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery

Yan Li et al.

Summary: The study utilized charge-switchable zwitterionic polycarboxybetaine (PCB) to load insulin and form PCB/insulin (PCB/INS) particles, which showed an opening effect on intestinal epithelium, increasing the intestinal permeability of insulin and enhancing the antidiabetic efficacy after oral administration.

THERANOSTICS (2021)

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Article Chemistry, Multidisciplinary

In vivo oral insulin delivery via covalent organic frameworks

Farah Benyettou et al.

Summary: This study introduces a novel approach using nCOF nanoparticles for oral insulin delivery, which demonstrated protection of insulin and glucose-responsive release in vitro, as well as hyperglycemia-induced release in vivo without toxic effects in diabetic rats. These findings suggest that nCOF-based oral insulin delivery systems could potentially replace traditional subcutaneous injections for insulin therapy.

CHEMICAL SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Oral Delivery of Biologics for Precision Medicine

Matilde Duran-Lobato et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Glucose-Responsive Insulin and Delivery Systems: Innovation and Translation

Jinqiang Wang et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Biomedical

Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

Nicholas G. Lamson et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Engineering, Biomedical

Bio-inspired microneedle design for efficient drug/vaccine coating

Cristina Plamadeala et al.

BIOMEDICAL MICRODEVICES (2020)

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Article Engineering, Environmental

Natural plant-derived polygalacturonic acid-oleanolic acid assemblies as oral-delivered nanomedicine for insulin resistance treatment

Yi Zhang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Multidisciplinary

Smart Protein-Based Formulation of Dendritic Mesoporous Silica Nanoparticles: Toward Oral Delivery of Insulin

Estelle Juere et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Discovery of an Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B

Chen Xie et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Chemistry, Physical

Progress in transdermal drug delivery systems for cancer therapy

Tianyue Jiang et al.

NANO RESEARCH (2020)

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Article Biotechnology & Applied Microbiology

Advances in oral peptide therapeutics

Daniel J. Drucker

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Multidisciplinary Sciences

Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy

Guojun Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Nanoscience & Nanotechnology

Materials for oral delivery of proteins and peptides

Tyler D. Brown et al.

NATURE REVIEWS MATERIALS (2020)

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Article Engineering, Biomedical

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

Jicheng Yu et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Nanoscience & Nanotechnology

A Nanocomposite Vehicle Based on Metal-Organic Framework Nanoparticle Incorporated Biodegradable Microspheres for Enhanced Oral Insulin Delivery

Yuhao Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Pharmacology & Pharmacy

Orally ingestible medical devices for gut engineering

Nikolaj Kofoed Mandsberg et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Pharmacology & Pharmacy

Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

D. J. Brayden et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Multidisciplinary Sciences

Developing a new class of engineered live bacterial therapeutics to treat human diseases

Mark R. Charbonneau et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Temporal pressure enhanced topical drug delivery through micropore formation

Daniel Chin Shivan Lio et al.

SCIENCE ADVANCES (2020)

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Article Nanoscience & Nanotechnology

Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions

Xiangfei Han et al.

NATURE NANOTECHNOLOGY (2020)

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Article Engineering, Biomedical

De novo development of proteolytically resistant therapeutic peptides for oral administration

Xu-Dong Kong et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Review Pharmacology & Pharmacy

Micro and nanoscale technologies in oral drug delivery

Samad Ahadian et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Chemistry, Multidisciplinary

Oral Insulin Delivery Platforms: Strategies To Address the Biological Barriers

Yufen Xiao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Pharmacology & Pharmacy

Effects of intestinal luminal contents and the importance of microfold cells on the ability of cell-penetrating peptides to enhance epithelial permeation of insulin

Noriyasu Kamei et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Article Biotechnology & Applied Microbiology

Oil-soluble reversed lipid nanoparticles for oral insulin delivery

Tao Wang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment

Tatsuya Fukuta et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Chemistry, Multidisciplinary

Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics

Xiao Han et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Comparison of Ionic Liquids and Chemical Permeation Enhancers for Transdermal Drug Delivery

Qin M. Qi et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Ionic-Liquid-Based Safe Adjuvants

Anvay Ukidve et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Biomedical

Targeted nanoparticles towards increased L cell stimulation as a strategy to improve oral peptide delivery in incretin-based diabetes treatment

Yining Xu et al.

BIOMATERIALS (2020)

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Article Chemistry, Applied

Carboxymethyl β-cyclodextrin grafted carboxymethyl chitosan hydrogel-based microparticles for oral insulin delivery

Yu Yang et al.

CARBOHYDRATE POLYMERS (2020)

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Article Multidisciplinary Sciences

Molecular engineering of safe and efficacious oral basal insulin

Frantisek Hubalek et al.

NATURE COMMUNICATIONS (2020)

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Review Chemistry, Multidisciplinary

Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules

Muhammad Mustafa Abeer et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Engineering, Biomedical

Tailored elasticity combined with biomimetic surface promotes nanoparticle transcytosis to overcome mucosal epithelial barrier

Yaxian Zheng et al.

BIOMATERIALS (2020)

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Article Immunology

A Novel Fusion of IL-10 Engineered to Traffic across Intestinal Epithelium to Treat Colitis

Nicole C. Fay et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Dual self-regulated delivery of insulin and glucagon by a hybrid patch

Zejun Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Trisulfide bond-mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Yinxian Yang et al.

SCIENCE ADVANCES (2020)

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Article Pharmacology & Pharmacy

Stable Monomeric Insulin Formulations Enabled by Supramolecular PEGylation of Insulin Analogues

Caitlin L. Maikawa et al.

ADVANCED THERAPEUTICS (2020)

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Article Materials Science, Biomaterials

Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery

Parinaz Sabourian et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Pharmacology & Pharmacy

SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs

Arshad Mahmood et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery

Amrita Banerjee et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Multidisciplinary Sciences

An ingestible self-orienting system for oral delivery of macromolecules

Alex Abramson et al.

SCIENCE (2019)

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Review Pharmacology & Pharmacy

Nanoparticles: Oral Delivery for Protein and Peptide Drugs

Shu-jun Cao et al.

AAPS PHARMSCITECH (2019)

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Review Endocrinology & Metabolism

The Discovery and Development of Liraglutide and Semaglutide

Lotte Bjerre Knudsen et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Article Cell Biology

Snake fang-inspired stamping patch for transdermal delivery of liquid formulations

Won-Gyu Bae et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Chemistry, Multidisciplinary

Engineering a Nanoscale Al-MOF-Armored Antigen Carried by a Trojan Horse-Like Platform for Oral Vaccination to Induce Potent and Long-Lasting Immunity

Yang-Bao Miao et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Nanoscience & Nanotechnology

Investigation Of Vitamin B12-Modified Amphiphilic Sodium Alginate Derivatives For Enhancing The Oral Delivery Efficacy Of Peptide Drugs

Lingli Long et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Chemistry, Multidisciplinary

Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs

Jiangkang Xu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies

Fiona McCartney et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota

Chenwen Li et al.

ADVANCED SCIENCE (2019)

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Article Nanoscience & Nanotechnology

Impact Of Penetratin Stereochemistry On The Oral Bioavailability Of Insulin-Loaded Solid Lipid Nanoparticles

Bader B. Alsulays et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Materials Science, Biomaterials

Bioinspired oral insulin delivery system using yeast microcapsules

Chinnu Sabu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Biochemistry & Molecular Biology

A luminal unfolding microneedle injector for oral delivery of macromolecules

Alex Abramson et al.

NATURE MEDICINE (2019)

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Article Pharmacology & Pharmacy

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Wenji Deng et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Review Pharmacology & Pharmacy

Advances in transdermal insulin delivery

Yuqi Zhang et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Microneedle-Array Patch Fabricated with Enzyme-Free Polymeric Components Capable of On-Demand Insulin Delivery

Siyuan Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Biochemical Research Methods

DM1 Loaded Ultrasmall Gold Nanoparticles Display Significant Efficacy and Improved Tolerability in Murine Models of Hepatocellular Carcinoma

Sarah J. M. Hale et al.

BIOCONJUGATE CHEMISTRY (2019)

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Review Pharmacology & Pharmacy

Yeast-inspired drug delivery: biotechnology meets bioengineering and synthetic biology

Chinnu Sabu et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Chemistry, Physical

Glucose-responsive oral insulin delivery for postprandial glycemic regulation

Jicheng Yu et al.

NANO RESEARCH (2019)

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Article Chemistry, Multidisciplinary

Stimuli-responsive self-assembled dendrimers for oral protein delivery

Zhiying Zeng et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Biotechnology & Applied Microbiology

Non-invasive delivery strategies for biologics

Aaron C. Anselmo et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Multidisciplinary Sciences

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

Pichet Praveschotinunt et al.

NATURE COMMUNICATIONS (2019)

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Article Nanoscience & Nanotechnology

Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin

Yining Xu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Pharmacology & Pharmacy

The role of mucus on drug transport and its potential to affect therapeutic outcomes

Xabier Murgia et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Editorial Material Pharmacology & Pharmacy

Towards Enhancing Skin Drug Delivery

Zhen Gu et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Review Pharmacology & Pharmacy

Current and future technological advances in transdermal gene delivery

Xianfeng Chen

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Review Pharmacology & Pharmacy

Polymeric microneedles for transdermal protein delivery

Yanqi Ye et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Article Engineering, Biomedical

Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery

Weiwei Fan et al.

BIOMATERIALS (2018)

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Review Chemistry, Multidisciplinary

Block Copolymer Micelles in Nanomedicine Applications

Horacio Cabral et al.

CHEMICAL REVIEWS (2018)

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Article Biochemistry & Molecular Biology

Characterization and Oral Delivery of Proinsulin-Transferrin Fusion Protein Expressed Using ExpressTec

Yu-Sheng Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Chemistry, Multidisciplinary

Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications

Vineet Kumar Rai et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Acid-Resistant Mesoporous Metal-Organic Framework toward Oral Insulin Delivery: Protein Encapsulation, Protection, and Release

Yijing Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Multidisciplinary Sciences

The external scent efferent system of selected European true bugs (Heteroptera): a biomimetic inspiration for passive, unidirectional fluid transport

Florian Hischen et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2018)

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Article Chemistry, Multidisciplinary

Cyclization of peptides with two chemical bridges affords large scaffold diversities

Sangram S. Kale et al.

NATURE CHEMISTRY (2018)

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Article Multidisciplinary Sciences

Ionic liquids for oral insulin delivery

Amrita Banerjee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Chemistry, Multidisciplinary

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery

Yuqi Zhang et al.

SMALL (2018)

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Article Engineering, Biomedical

Uniform Core-Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin

Houkuan Tian et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Chemistry, Analytical

In Vivo Experimental Study of Noninvasive Insulin Microinjection through Hollow Si Microneedle Array

Drago Resnik et al.

MICROMACHINES (2018)

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Article Biotechnology & Applied Microbiology

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

Vincent M. Isabella et al.

NATURE BIOTECHNOLOGY (2018)

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Article Cell Biology

Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

Stephen T. Buckley et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Biotechnology & Applied Microbiology

Heat: A Highly efficient Skin enhancer for Transdermal Drug Delivery

Sabine Szunerits et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

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Article Chemistry, Medicinal

Synthesis and characterization of insulin/zirconium phosphate@TiO2 hybrid composites for enhanced oral insulin delivery applications

Mostafa Safari et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2017)

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Review Nanoscience & Nanotechnology

Bioresponsive materials

Yue Lu et al.

NATURE REVIEWS MATERIALS (2017)

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Article Chemistry, Multidisciplinary

Delivery of immunoreactive antigen using a controllable needle-free jet injector

N. Catherine Hogan et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Pharmacology & Pharmacy

Intestinal micropatches for oral insulin delivery

Amrita Banerjee et al.

JOURNAL OF DRUG TARGETING (2017)

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Article Medicine, General & Internal

The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial

Nadine G. Rouphael et al.

LANCET (2017)

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Article Medicine, General & Internal

Comparison of jet injector and insulin pen in controlling plasma glucose and insulin concentrations in type 2 diabetic patients

Lixin Guo et al.

MEDICINE (2017)

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Article Chemistry, Multidisciplinary

Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

Jicheng Yu et al.

NANO LETTERS (2017)

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Article Multidisciplinary Sciences

Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy

Wei Chen et al.

NATURE COMMUNICATIONS (2017)

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Review Biochemical Research Methods

Bioresponsive transcutaneous patches

Jicheng Yu et al.

CURRENT OPINION IN BIOTECHNOLOGY (2017)

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Article Chemistry, Multidisciplinary

Plant-Based Hollow Microcapsules for Oral Delivery Applications: Toward Optimized Loading and Controlled Release

Michael G. Potroz et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Review Chemistry, Multidisciplinary

Orally Absorbed Cyclic Peptides

Daniel S. Nielsen et al.

CHEMICAL REVIEWS (2017)

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Article Chemistry, Multidisciplinary

Long-Acting Release Formulation of Exendin-4 Based on Biomimetic Mineralization for Type 2 Diabetes Therapy

Wei Chen et al.

ACS NANO (2017)

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Article Chemistry, Multidisciplinary

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

Xiuli Hu et al.

ACS NANO (2017)

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Article Chemistry, Multidisciplinary

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

Yanqi Ye et al.

ACS NANO (2016)

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Editorial Material Pharmacology & Pharmacy

Oral delivery of peptides: opportunities and issues for translation

David J. Brayden et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Pharmacology & Pharmacy

Oral delivery of macromolecular drugs: Where we are after almost 100 years of attempts

Elena Moroz et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Pharmacology & Pharmacy

Intestinal permeation enhancers for oral peptide delivery

Sam Maher et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Chemistry, Multidisciplinary

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery

Yanqi Ye et al.

ADVANCED MATERIALS (2016)

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Article Chemistry, Multidisciplinary

Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins

Xi Zhu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Review Chemistry, Multidisciplinary

Mechanical Force-Triggered Drug Delivery

Yuqi Zhang et al.

CHEMICAL REVIEWS (2016)

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Article Pharmacology & Pharmacy

On prilled Nanotubes-in-Microgel Oral Systems for protein delivery

Jan Kendall de Kruif et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

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Review Chemistry, Multidisciplinary

Critical evaluation and methodological positioning of the transdermal microdialysis technique. A review

Franciska Erdo et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery

Michael Clinton Koetting et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

The application of local hypobaric pressure - A novel means to enhance macromolecule entry into the skin

R. Inacio et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Biotechnology & Applied Microbiology

Oral Delivery of Protein Drugs Bioencapsulated in Plant Cells

Kwang-Chul Kwon et al.

MOLECULAR THERAPY (2016)

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Article Chemistry, Multidisciplinary

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

Chao Wang et al.

NANO LETTERS (2016)

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Article Chemistry, Multidisciplinary

Peptides as skin penetration enhancers: Mechanisms of action

Sunny Kumar et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Medicinal

Microneedles for Drug Delivery via the Gastrointestinal Tract

Giovanni Traverso et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

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Article Chemistry, Physical

A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices

Shiyi Zhang et al.

NATURE MATERIALS (2015)

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Article Multidisciplinary Sciences

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

Jicheng Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Chemistry, Multidisciplinary

Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Hywel D. Williams et al.

CHEMICAL COMMUNICATIONS (2014)

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Article Chemistry, Multidisciplinary

In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin

Ebbe Juel Bech Nielsen et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Review Biotechnology & Applied Microbiology

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

Samir Mitragotri et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

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Article Dermatology

Treatment of Nail Psoriasis with Intralesional Triamcinolone Acetonide Using a Needle-Free Jet Injector: A Prospective Trial

Melissa Nantel-Battista et al.

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY (2014)

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Review Chemistry, Multidisciplinary

Boronic acid-containing hydrogels: synthesis and their applications

Ying Guan et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Article Medicine, Research & Experimental

Effect of Cationic Cyclopeptides on Transdermal and Transmembrane Delivery of Insulin

Mingming Chang et al.

MOLECULAR PHARMACEUTICS (2013)

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Article Chemistry, Multidisciplinary

Releasable Layer-by-Layer Assembly of Stabilized Lipid Nanocapsules on Microneedles for Enhanced Transcutaneous Vaccine Delivery

Peter C. DeMuth et al.

ACS NANO (2012)

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Review Pharmacology & Pharmacy

Oral biodrug delivery using cell-penetrating peptide

El-Sayed Khafagy et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Article Engineering, Biomedical

Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin

MinYoung Kim et al.

BIOMATERIALS (2012)

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Review Pharmacology & Pharmacy

The structure and function of the stratum corneum

Gopinathan K. Menon et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Article Chemistry, Multidisciplinary

Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications

C. J. Martin et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Review Chemistry, Multidisciplinary

Microneedle technologies for (trans)dermal drug and vaccine delivery

Koen van der Maaden et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Review Chemistry, Multidisciplinary

Organization of Glucose-Responsive Systems and Their Properties

Qian Wu et al.

CHEMICAL REVIEWS (2011)

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Review Chemistry, Multidisciplinary

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

Yiyun Cheng et al.

CHEMICAL SOCIETY REVIEWS (2011)

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Review Chemistry, Multidisciplinary

Tailoring nanocarriers for intracellular protein delivery

Zhen Gu et al.

CHEMICAL SOCIETY REVIEWS (2011)

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Article Endocrinology & Metabolism

Painless Skin Electroporation as a Novel Way for Insulin Delivery

Tak-Wah Wong et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2011)

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Review Chemistry, Multidisciplinary

Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends

Baris E. Polat et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Physics, Multidisciplinary

Tears of Venom: Hydrodynamics of Reptilian Envenomation

Bruce A. Young et al.

PHYSICAL REVIEW LETTERS (2011)

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Article Chemistry, Multidisciplinary

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

Richard J. Clark et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

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Article Pharmacology & Pharmacy

Effect of different enhancers on the transdermal permeation of insulin analog

K. M. Yerramsetty et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Article Biochemistry & Molecular Biology

Dissolving polymer microneedle patches for influenza vaccination

Sean P. Sullivan et al.

NATURE MEDICINE (2010)

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Review Chemistry, Multidisciplinary

Traveling the Vitamin B-12 Pathway: Oral Delivery of Protein and Peptide Drugs

Amanda K. Petrus et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

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Article Chemistry, Multidisciplinary

Microneedle arrays for the transcutaneous immunization of diphtheria and influenza in BALB/c mice

Z. Ding et al.

JOURNAL OF CONTROLLED RELEASE (2009)

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Article Chemistry, Multidisciplinary

Synthesis, Characterization and In Vivo Efficacy of PEGylated Insulin for Oral Delivery with Complexation Hydrogels

Anthony D. Tuesca et al.

PHARMACEUTICAL RESEARCH (2009)

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Review Biotechnology & Applied Microbiology

Therapeutic application of peptides and proteins: parenteral forever?

Zuzana Antosova et al.

TRENDS IN BIOTECHNOLOGY (2009)

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Review Immunology

Intestinal mucosal barrier function in health and disease

Jerrold R. Turner

NATURE REVIEWS IMMUNOLOGY (2009)

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Article Mechanics

Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery

Constantin C. Coussios et al.

Annual Review of Fluid Mechanics (2008)

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Review Biotechnology & Applied Microbiology

Transdermal drug delivery

Mark R. Prausnitz et al.

NATURE BIOTECHNOLOGY (2008)

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Article Chemistry, Medicinal

Vitamin B12 as a carrier for the oral delivery of insulin

Amanda K. Petrus et al.

CHEMMEDCHEM (2007)

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Article Chemistry, Multidisciplinary

Topical iodine facilitates transdermal delivery of insulin

Amnon C. Sintov et al.

JOURNAL OF CONTROLLED RELEASE (2007)

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Article Pharmacology & Pharmacy

Reversible lipidization for the oral delivery of leu-enkephalin

J Wang et al.

JOURNAL OF DRUG TARGETING (2006)

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Article Biotechnology & Applied Microbiology

Transdermal protein delivery by a coadministered peptide identified via phage display

YP Chen et al.

NATURE BIOTECHNOLOGY (2006)

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Article Dermatology

Dermojet delivery of bleomycin for the treatment of recalcitrant plantar warts

E Agius et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2006)

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Article Oncology

Patients' preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancer

L Fallowfield et al.

ANNALS OF ONCOLOGY (2006)

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Article Biophysics

The penetration of a soft solid by a liquid jet, with application to the administration of a needle-free injection

Oliver A. Shergold et al.

JOURNAL OF BIOMECHANICS (2006)

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Review Biotechnology & Applied Microbiology

Protein therapeutics: new applications for pharmacogenetics

Cecile Krejsa et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

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Review Immunology

Immunization without needles

S Mitragotri

NATURE REVIEWS IMMUNOLOGY (2005)

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Article Chemistry, Multidisciplinary

Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts

KH Song et al.

JOURNAL OF CONTROLLED RELEASE (2005)

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Article Engineering, Biomedical

Sugar micro needles as transdermic drug delivery system

T Miyano et al.

BIOMEDICAL MICRODEVICES (2005)

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Article Obstetrics & Gynecology

Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis

SC Low et al.

HUMAN REPRODUCTION (2005)

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Article Multidisciplinary Sciences

Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent

Y Bai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Review Chemistry, Physical

Biomimetism and bioinspiration as tools for the design of innovative materials and systems

C Sanchez et al.

NATURE MATERIALS (2005)

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Article Chemistry, Multidisciplinary

Transdermal delivery of human growth hormone through RF-microchannels

G Levin et al.

PHARMACEUTICAL RESEARCH (2005)

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Article Multidisciplinary Sciences

Design principles of chemical penetration enhancers for transdermal drug delivery

P Karande et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Review Biotechnology & Applied Microbiology

Current status and future potential of transdermal drug delivery

MR Prausnitz et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

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Review Biotechnology & Applied Microbiology

Challenges for the oral delivery of macromolecules

M Goldberg et al.

NATURE REVIEWS DRUG DISCOVERY (2003)

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Review Pharmacology & Pharmacy

Chemistry for peptide and protein PEGylation

MJ Roberts et al.

ADVANCED DRUG DELIVERY REVIEWS (2002)

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