A rapid and sensitive LC-ESI-MS/MS method for determining vincristine in micro-volumes of plasma for pediatric cancer patients

Review Toxicology

Proactive therapeutic drug monitoring of vincristine in pediatric and adult cancer patients: current supporting evidence and future efforts

Chun-Ying Wu et al.

Summary: This review summarizes the research progress and current issues of therapeutic drug monitoring (TDM) in vincristine treatment, emphasizing the importance of individualized therapy.

ARCHIVES OF TOXICOLOGY (2023)

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Article Oncology

Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients

Shelby Barnett et al.

Summary: This study investigated vincristine dosing, drug exposure, and the feasibility of therapeutic drug monitoring in neonate and infant patients. The results suggest that doses of <0.05mg/kg should not be used in this population due to a risk of suboptimal drug exposures, and therapeutic drug monitoring approaches are effective.

EUROPEAN JOURNAL OF CANCER (2022)

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Article Chemistry, Analytical

A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS

L. T. van der Heijden et al.

Summary: A highly sensitive method using LC-MS/MS was developed for quantification of vinblastine, vincristine, vinorelbine, and its active metabolite in human plasma. The method was successfully applied in pharmacokinetic studies and in vivo mouse models research.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

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Review Biochemistry & Molecular Biology

Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment

Silvia Triarico et al.

Summary: Vincristine-induced peripheral neurotoxicity (VIPN) is a common side effect in pediatric cancer patients undergoing vincristine chemotherapy, leading to potential complications such as treatment delays or discontinuation. The pathogenesis of VIPN involves complex mechanisms including damage to nerve cell endothelium, mitochondria, and microtubules, with both patient-related and treatment-related factors contributing to its development. Despite research into various drugs for prophylaxis and treatment, consensus on the best approach for VIPN management in pediatric oncology patients remains elusive.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Toxicity and pharmacokinetics of actinomycin-D and vincristine in children and adolescents: Children's Oncology Group Study ADVL06B1

Jeffrey Skolnik et al.

Summary: Actinomycin-D and vincristine, commonly used cytotoxic drugs for treating childhood cancers, exhibit high pharmacokinetic variability. Demographic and pharmacokinetic parameters did not correlate with target toxicities for Actinomycin-D, while age and body surface area correlations with neuropathy for vincristine were confounded by various factors. Variability may be attributed to dose reductions and capped doses, warranting further investigation into body surface area-based dosing in young children.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2021)

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Article Oncology