Aluminum(III)-Based Organic Nanofibrous Gels as an Aggregation-Induced Electrochemiluminescence Emitter Combined with a Rigid Triplex DNA Walker as a Signal Magnifier for Ultrasensitive DNA Assay

Article Chemistry, Multidisciplinary

DNA Assembly of Modular Components into a Rotary Nanodevice

Andreas Peil et al.

Summary: Researchers have successfully demonstrated the DNA assembly of a rotary nanodevice that mimics the mechanism of bacterial flagellar motor. This study provides new insights for designing and building artificial nanomachinery.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

A Novel Electrochemiluminescence Janus Emitter for Dual-Mode Biosensing

Tingting Han et al.

Summary: A novel electrochemiluminescence (ECL) Janus emitter combining ruthenium (II) complex and luminol polymer doped hemispheres enables dual-mode biosensing for multiple disease-related biomarkers from cells. It eliminates interference between different ECL mono-luminophores, improving ECL efficiency and detection sensitivity. It also enables ratiometric ECL sensing of H2O2 and simultaneous identification and quantification of cancer-related dual microRNAs.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Analytical

An Immunosensor Using Electroactive COF as Signal Probe for Electrochemical Detection of Carcinoembryonic Antigen

Huihui Liang et al.

Summary: Two-dimensional covalent-organic frameworks (COF) were used to construct a sandwich-type electrochemical immunosensor for the quantitative detection of carcinoembryonic antigen (CEA). The immunosensor exhibited a wide detection range and a low detection limit.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Single-Nanoparticle Collision Electrochemistry Biosensor Based on an Electrocatalytic Strategy for Highly Sensitive and Specific Detection of H7N9 Avian Influenza Virus

Yan-Ju Yang et al.

Summary: This paper presents a highly sensitive and specific biosensor for the detection of H7N9 avian influenza virus based on single-nanoparticle collision electrochemistry (SNCE) and electrocatalytic strategy. By introducing nucleic acid aptamers and cyclic amplification, the biosensor achieved indirect detection of the target virus with improved detection sensitivity and specificity.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Single-Atom Iron Enables Strong Low-Triggering-Potential Luminol Cathodic Electrochemiluminescence

Wenling Gu et al.

Summary: In this study, iron single-atom catalysts were used as efficient co-reaction accelerators to achieve strong cathodic electrochemiluminescence at an ultralow potential. The catalysts activate H2O2 to produce reactive oxygen species, which directly react with a luminol to generate intense emission.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Electrochemiluminescent Transistors: A New Strategy toward Light-Emitting Switching Devices

Seonjeong Lee et al.

Summary: This study introduces a novel ECLT device platform, demonstrating successful fabrication of high-performance LETs using various conventional non-emissive semiconductors, with high carrier mobility and uniform light emission achieved.

ADVANCED MATERIALS (2021)

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Article Chemistry, Analytical

Aggregation-Induced Electrochemiluminescence Bioconjugates of Apoferritin-Encapsulated Iridium(III) Complexes for Biosensing Application

Lei Yang et al.

Summary: An AIECL bioconjugate was developed by encapsulating Ir(ppy)(3) complexes in apoFt, enhancing ECL emission and enabling sensitive detection of CYFRA 21-1. This study demonstrates the potential for utilizing apoFt in designing iridium(III)-based AIECL emitters for innovative ECL immunoassays.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce2Sn2O7 Nanocubes

Malik Saddam Khan et al.

Summary: A novel and simple label-free electrochemiluminescence immunosensor was proposed using Ce2Sn2O7 nanocubes as ECL emitters, which were functionalized with gold nanoparticles to enhance ECL emission. The immunosensor showed improved ECL performance for detecting CEA concentrations, with outstanding stability, reproducibility, and specificity, making it an innovative method for sensitive analysis of biomarkers in real samples.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Single-Particle Electrochemical Biosensor with DNA Walker Amplification for Ultrasensitive HIV-DNA Counting

Fanwei Luo et al.

Summary: The integration of magnetic separation and DNA walker amplification has resulted in a robust and sensitive single-particle electrochemical biosensor. This method effectively captures and separates targets from complex samples, avoiding interference and aggregation, leading to cyclic amplification and greatly enhanced detection sensitivity. The ultrasensitive detection of HIV DNA in complex systems demonstrates promising potential for real sample applications and the development of new single-entity biosensors.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Spatially Selective Imaging of Cell-Matrix and Cell-Cell Junctions by Electrochemiluminescence

Hao Ding et al.

Summary: A novel method for spatially selective imaging of cell junctions by regulating the thickness of the electrochemiluminescence (ECL) layer through control of luminophore and co-reactant concentrations has been reported. Low luminophore concentration reveals cell-matrix adhesions, while high concentration allows sequential imaging of cell-matrix and cell-cell junctions. This strategy not only provides new insights into ECL mechanisms but also expands the potential applications of ECL microscopy in bioimaging.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Biotechnology & Applied Microbiology

Rolling Circle Replication for Biosensing, Bioimaging, and Biomedicine

Shuzhen Yue et al.

Summary: Rolling circle replication (RCR) is an efficient biosensing tool that has been extended to bioimaging and biomedicine. By designing and generating DNA/RNA structures, it can deliver drugs and improve targeting ability.

TRENDS IN BIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Near-Infrared Light Controllable DNA Walker Driven by Endogenous Adenosine Triphosphate for in Situ Spatiotemporal Imaging of Intracellular MicroRNA

Mingqiang Ye et al.

Summary: A NIR-photoactivatable DNA walker system powered by endogenous ATP was developed for in situ miRNA imaging in living cells with high spatial and temporal resolution. The system utilized UCNPs as carriers and transducers, showing stability and low fluorescent background. This smart system based on NIR light initiated DNA walker successfully achieved precise spatiotemporal control in living cells and has been applied for in situ miRNA imaging with high resolution.

ACS NANO (2021)

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Article Chemistry, Analytical

CRISPR/Cas12a-Assisted Ligation-Initiated Loop-Mediated Isothermal Amplification (CAL-LAMP) for Highly Specific Detection of microRNAs

Mai Zhang et al.

Summary: A CRISPR/Cas12a-assisted sequence-specific detection method for LAMP products was developed to eliminate non-specific amplification effects. By designing target-specific stem-loop DNA probes, primer design for LAMP was greatly simplified, achieving sensitive detection of miRNAs with high specificity.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Flap Endonuclease 1-Assisted DNA Walkers for Sensitively and Specifically Sensing ctDNAs

Xianyi Cheng et al.

Summary: A DNA walker assisted by flap endonuclease 1 (FEN 1) has been proposed to achieve mutant biosensing with high specificity and sensitivity. The system is capable of discriminating single-base mutant DNA targets from wild-type DNA, and can detect DNA targets as low as 1 fM and mutation abundance as low as 0.1%. Detection of epidermal growth factor receptor (EGFR) L858R mutation on cell-free DNA samples showed results consistent with next-generation sequencing, indicating the potential of the DNA walker for liquid biopsy.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Aggregation-induced delayed fluorescence luminogens: the innovation of purely organic emitters for aqueous electrochemiluminescence

Baohua Zhang et al.

Summary: This study introduces a new aqueous electrochemiluminescence (ECL) technique based on aggregation-induced delayed fluorescence (AIDF) luminogens. Compared with traditional organic AIE luminogens, AIDF luminogens show higher ECL efficiency.

CHEMICAL SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Simple Single-Legged DNA Walkers at Diffusion-Limited Nanointerfaces of Gold Nanoparticles Driven by a DNA Circuit Mechanism

Motoi Oishi et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Dual Enhancement of Gold Nanocluster Electrochemiluminescence: Electrocatalytic Excitation and Aggregation-Induced Emission

Huaping Peng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Analytical

Aggregation-Induced Electrochemiluminescence of the Dichlorobis(1,10-phenanthroline)ruthenium(II) (Ru(phen)2Cl2)/Tri-n-propylamine (TPrA) System in H2O-MeCN Mixtures for Identification of Nucleic Acids

Liping Lu et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Improved AIE-Active Probe with High Sensitivity for Accurate Uranyl Ion Monitoring in the Wild Using Portable Electrochemiluminescence System for Environmental Applications

Ziyu Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Multidisciplinary Sciences

Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics

Angela C. Stelson et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Aggregation-Induced Electrochemiluminescence by Metal-Binding Protein Responsive Hydrogel Scaffolds

Hui Jiang et al.

SMALL (2019)

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Article Chemistry, Multidisciplinary

Two-Photon Lithographic Patterning of DNA-Coated Single-Microparticle Surfaces

Fujian Huang et al.

NANO LETTERS (2019)

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Article Chemistry, Analytical

Highly Sensitive and Automated Surface Enhanced Raman Scattering-based Immunoassay for H5N1 Detection with Digital Microfluidics

Yang Wang et al.

ANALYTICAL CHEMISTRY (2018)

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Review Chemistry, Multidisciplinary

Optical nano-biosensing interface via nucleic acid amplification strategy: construction and application

Hong Zhou et al.

CHEMICAL SOCIETY REVIEWS (2018)

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Article Chemistry, Multidisciplinary

Highly Ordered and Field-Free 3D DNA Nanostructure: The Next Generation of DNA Nanomachine for Rapid Single-Step Sensing

Pu Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Chemistry, Multidisciplinary

Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants

Yongya Li et al.

CHEMICAL SCIENCE (2018)

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Article Chemistry, Analytical

Terbium(III) Organic Gels: Novel Antenna Effect-Induced Enhanced Electrochemiluminescence Emitters

Yang Li et al.

ANALYTICAL CHEMISTRY (2018)

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Article Multidisciplinary Sciences

A CRISPR-Cas9-triggered strand displacement amplification method for ultrasensitive DNA detection

Wenhua Zhou et al.

NATURE COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

Aggregation-Induced Electrochemiluminescence of Platinum(II) Complexes

Serena Carrara et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Review Chemistry, Multidisciplinary

Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging, and biomedicine

Sai Bi et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Article Nanoscience & Nanotechnology

A stochastic DNA walker that traverses a microparticle surface

C. Jung et al.

NATURE NANOTECHNOLOGY (2016)

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Article Biophysics

Highly sensitive visual detection of Avian Influenza A (H7N9) virus based on the enzyme-induced metallization

Huifang Zhang et al.

BIOSENSORS & BIOELECTRONICS (2016)

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Review Chemistry, Multidisciplinary

Isothermal Amplification of Nucleic Acids

Yongxi Zhao et al.

CHEMICAL REVIEWS (2015)

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Article Multidisciplinary Sciences

Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components

Thomas Gerling et al.

SCIENCE (2015)

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Article Chemistry, Multidisciplinary

Rapid, Sensitive, and Quantitative Detection of Pathogenic DNA at the Point of Care through Microfluidic Electrochemical Quantitative Loop-Mediated Isothermal Amplification

Kuangwen Hsieh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Article Chemistry, Multidisciplinary

An Autonomous and Controllable Light-Driven DNA Walking Device

Mingxu You et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Article Chemistry, Multidisciplinary

DNA Machines: Bipedal Walker and Stepper

Zhen-Gang Wang et al.

NANO LETTERS (2011)

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Article Chemistry, Multidisciplinary

Effect of surface passivation on the electrogenerated chemiluminescence of CdSe/ZnSe nanocrystals

N Myung et al.

NANO LETTERS (2003)

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Article Chemistry, Multidisciplinary

Electrogenerated chemiluminescence of CdSe nanocrystals

N Myung et al.

NANO LETTERS (2002)

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Article Biochemical Research Methods

Accelerated reaction by loop-mediated isothermal amplification using loop primers

K Nagamine et al.

MOLECULAR AND CELLULAR PROBES (2002)

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Article Multidisciplinary Sciences

Electrochemistry and electrogenerated chemiluminescence from silicon nanocrystal quantum dots

ZF Ding et al.

SCIENCE (2002)

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Article Biochemistry & Molecular Biology

Loop-mediated isothermal amplification of DNA

Tsugunori Notomi et al.

NUCLEIC ACIDS RESEARCH (2000)

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Aluminum(III)-Based Organic Nanofibrous Gels as an Aggregation-Induced Electrochemiluminescence Emitter Combined with a Rigid Triplex DNA Walker as a Signal Magnifier for Ultrasensitive DNA Assay

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