Measurement of Minute Liquid Volumes of Chiral Molecules Using In-Fiber Polarimetry

We report an optofluidic method that enables to efficiently measure the enantiomeric excess of chiral molecules at low concentrations. The approach is to monitor the optical activity induced by a Kagome-lattice hollow core photonic crystal fiber filled with a sub-mu L volume of chiral compounds. The technique also allows monitoring the enzymatic racemization of Rmandelic acid.

Automated summary

We have developed an optofluidic method for efficient measurement of enantiomeric excess of chiral molecules at low concentrations. This method involves monitoring the optical activity induced by a Kagome-lattice hollow core photonic crystal fiber filled with a sub-mu L volume of chiral compounds. It also allows monitoring enzymatic racemization of R-mandelic acid.