Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor

Article Chemistry, Analytical

A highly sensitive NIR fluorescence probe for hypoxia imaging in cells and ulcerative colitis

Sheng Wang et al.

Summary: A new fluorescence probe was developed for hypoxia imaging in ulcerative colitis, showing high sensitivity and low detection limit. The probe demonstrated promising application potential in live cells, tumors, and mouse models.

TALANTA (2023)

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Article Chemistry, Analytical

Colorimetric Sensing of Hydrogen Peroxide Based on the Wavelength-Shift of CsPbBr3 Perovskite Nanocrystals on Water-Oil Interface

Heng-Gan Li et al.

Summary: This study investigates the halogen exchange reactions in aqueous solution on CsPbBr3 NCs and demonstrates their potential application in sensing I- and H2O2 concentrations.

JOURNAL OF ANALYSIS AND TESTING (2023)

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Review Chemistry, Multidisciplinary

Small Molecule Fluorescent Probes for Sensing and Bioimaging of Nitroreductase

Samarpita Das et al.

Summary: Hypoxia is a condition caused by a decrease in oxygen and can have various negative effects on the body, especially in cancer patients. Developing diagnostic tools to monitor specific markers of hypoxia, such as NTR, is crucial for improving treatment efficacy. Fluorescent probes have been developed to measure NTR activity.

CHEMISTRYSELECT (2022)

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Article Chemistry, Analytical

Fluorogenic and Mitochondria-Localizable Probe Enables Selective Labeling and Imaging of Nitroreductase

Shuyi Wang et al.

Summary: This study presents the design and synthesis of a new NTR fluorescent probe FY, which achieves permanent retention and enhanced spatial resolution by integrating with QM protein labeling. Compared to conventional fluorescent probes, FY offers mitochondrial localization, fluorogenic response, and high detection sensitivity even after cell fixation.

ANALYTICAL CHEMISTRY (2022)

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Article Engineering, Biomedical

Two-Photon Small-Molecule Fluorogenic Probes for Visualizing Endogenous Nitroreductase Activities from Tumor Tissues of a Cancer Patient

Changmin Yu et al.

Summary: This study successfully developed a series of two-photon small-molecule fluorogenic probes capable of sensitively detecting general NTR activities in various biological samples. The optimized probe, X4, displayed the best performance in terms of sensitivity and selectivity. X4 also showed excellent two-photon excited fluorescence properties and was able to directly monitor endogenous NTR activities in live cells, growing zebrafish, and tumor-bearing mice. By using its outstanding tissue-penetrating imaging property, X4 was used for the first time to detect endogenous NTR activities in liver and cardia tissues from a cancer patient.

ADVANCED HEALTHCARE MATERIALS (2022)

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Review Chemistry, Analytical

Recent Progress in Fluorescent Formaldehyde Detection Using Small Molecule Probes

Jiao-Jiao Zheng et al.

Summary: This review provides a comprehensive summary of recent research on fluorescent analysis of formaldehyde using small molecule probes. It discusses the sensing mechanisms, detection methods, and performance in various environments, as well as the challenges and future trends in formaldehyde detection based on fluorescent probes.

JOURNAL OF ANALYSIS AND TESTING (2022)

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Article Chemistry, Analytical

Activatable near-infrared fluorescent probe triggered by nitroreductase for in vivo ulcerative colitis hypoxia imaging

He-Song Wang et al.

Summary: Ulcerative colitis is a common inflammatory disease related to hypoxia in the colon microenvironment. Researchers have developed a new probe for detecting overexpressed nitroreductase (NTR) and conducting in vivo hypoxia imaging.

ANALYTICA CHIMICA ACTA (2022)

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Article Chemistry, Analytical

Ultrasensitive near-infrared fluorescence probe activated by nitroreductase for in vivo hypoxia detection

Qiao Lin et al.

Summary: In this study, a high-efficiency near-infrared fluorescence probe, YQ-NO2, was synthesized for detecting hypoxia. The probe showed high specificity in vitro and had the characteristics of low background inference, fast response, and prolonged imaging time in vivo. It was also capable of continuously monitoring cell hypoxia and accurately imaging ischemic sites.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Mitochondria-specific two-photon fluorogenic probe for simultaneously visualizing nitroreductase and viscosity in cancer cells

Wei Du et al.

Summary: A dual-functional fluorescent probe, CQ-1, was designed for rapid and accurate detection of early cancer biomarkers. It can visualize the changes of nitroreductase and viscosity in cancer cell mitochondria while displaying mitochondrial targeting ability.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Nanoscience & Nanotechnology

Near-Infrared Fluorescent Probes with Amine-Incorporated Xanthene Platforms for the Detection of Hypoxia

Shulin Wan et al.

Summary: Three near-infrared fluorescent probes A, B, and C have been developed to identify hypoxia via nitroreductase determinations. Theoretical calculations suggest the probes are not planar, and photon absorptions result in electron density transitions.

ACS APPLIED BIO MATERIALS (2022)

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Article Chemistry, Analytical

Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6/STAT3 Activation as Revealed by a Specific Biosensor

Wu-Yingzheng Guo et al.

Summary: PGP-I, identified as a novel inflammatory cytokine, is found to be involved in the development of HCC and could serve as a potential biomarker and therapeutic target for HCC. Bioimaging with a specific biosensor revealed aberrant expression of PGP-I in HCC cells, leading to tumor progression.

ANALYTICAL CHEMISTRY (2021)

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Review Chemistry, Analytical

Diagnostic Techniques for COVID-19: A Mini-review of Early Diagnostic Methods

Gao-Pan Dong et al.

Summary: The outbreak of severe pneumonia caused by SARS-CoV-2 virus spread rapidly worldwide through human-to-human transmission, leading to a high number of suspected cases and massive daily testing requirements. The medical pressure increased significantly, necessitating the urgent establishment of more efficient and accurate diagnostic methods.

JOURNAL OF ANALYSIS AND TESTING (2021)

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Review Chemistry, Multidisciplinary

Recent progress in fluorescent probes for bacteria

Yurou Huang et al.

Summary: Bacteria are closely related to food fermentation, antibiotics, and pollutant degradation, playing both essential and harmful roles in human life. Therefore, effective strategies for accurate monitoring of bacteria are urgently needed. Fluorescence imaging technology, especially the design of organic fluorescent probes, has shown great potential in the detection and imaging of bacteria, offering high specificity and sensitivity with minimal invasiveness.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Recent progress of aggregation-induced emission luminogens (AIEgens) for bacterial detection and theranostics

Xuping Feng et al.

Summary: Bacterial infections present a significant threat to human health, and addressing bacterial resistance is urgent. The development of AIEgens offers a promising new approach for bacterial detection and therapy.

MATERIALS CHEMISTRY FRONTIERS (2021)

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Article Chemistry, Analytical

A mitochondria-targeting nitroreductase fluorescent probe with large Stokes shift and long-wavelength emission for imaging hypoxic status in tumor cells

Quanzhi Yang et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

Activatable fluorescent probe based on aggregation-induced emission for detecting hypoxia-related pathological conditions

Lingfeng Xu et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Multidisciplinary

An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria

Benjamin Brennecke et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Analytical

Rational design of a nitroreductase-activatable two-photon fluorescent probe for hypoxia imaging in cell and in vivo

Yue Wang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Analytical

Activatable Nanocomposite Probe for Preoperative Location and Intraoperative Navigation for Orthotopic Hepatic Tumor Resection via MSOT and Aggregation-Induced Near-IR-I/II Fluorescence Imaging

Zhuo Zeng et al.

ANALYTICAL CHEMISTRY (2020)

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Review Chemistry, Analytical

Electrochemical Immuno- and Aptamer-Based Assays for Bacteria: Pros and Cons over Traditional Detection Schemes

Rimsha Binte Jamal et al.

SENSORS (2020)

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Article Spectroscopy

One step synthesis of red-emitting fluorescence turn-on probe for nitroreductase and its application to bacterial detection and oral cancer cell imaging

Shan Jiao et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

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Article Chemistry, Analytical

Hypoxia imaging in living cells, tissues and zebrafish with a nitroreductase-specific fluorescent probe

Li Fan et al.

ANALYST (2020)

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Article Chemistry, Multidisciplinary

Rapid differentiation between bacterial infections and cancer using a near-infrared fluorogenic probe

Ling-Ling Wu et al.

CHEMICAL SCIENCE (2020)

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Article Chemistry, Analytical

Evolving a Unique Red-Emitting Fluorophore with an Optically Tunable Hydroxy Group for Imaging Nitroreductase in Cells, in Tissues, and in Vivo

Rong Peng et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

An efficient fluorescence sensor for nitroreductase selective imaging based on intramolecular photoinduced electron transfer

Na Zhang et al.

TALANTA (2019)

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Article Materials Science, Biomaterials

A fluorescent probe for simultaneously sensing NTR and hNQO1 and distinguishing cancer cells

Fanpeng Kong et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Materials Science, Biomaterials

Development of a red-light emission hypoxia-sensitive two-photon fluorescent probe for in vivo nitroreductase imaging

Kalayou Hiluf Gebremedhin et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Review Chemistry, Multidisciplinary

Recent progress in small molecule fluorescent probes for nitroreductase

Wenjing Qin et al.

CHINESE CHEMICAL LETTERS (2018)

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Article Chemistry, Organic

A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cell

Zhaoshuai He et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2018)

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Review Plant Sciences

Chlorophyll fluorescence emission spectroscopy of oxygenic organisms at 77 K

J. J. Lamb et al.

PHOTOSYNTHETICA (2018)

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Article Spectroscopy

Construction of an efficient two-photon fluorescent probe for imaging nitroreductase in live cells and tissues

Liyi Zhou et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2018)

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Article Spectroscopy

Endoplasmic reticulum-targeted two-photon turn-on fluorescent probe for nitroreductase in tumor cells and tissues

An Xu et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2018)

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Article Chemistry, Analytical

A novel fluorescent turn-on probe for highly selective detection of nitroreductase in tumor cells

Kangning Zhu et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

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Article Chemistry, Multidisciplinary

Ultrasensitive Near-Infrared Fluorescence-Enhanced Probe for in Vivo Nitroreductase Imaging

Yuhao Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Review Pathology

Nonculture Molecular Techniques for Diagnosis of Bacterial Disease in Animals: A Diagnostic Laboratory Perspective

H. Y. Cai et al.

VETERINARY PATHOLOGY (2014)

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Article Chemistry, Analytical

Electroanalytical studies on green leaf volatiles for potential sensor development

Yogeswaran Umasankar et al.

ANALYST (2012)

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Review Plant Sciences

Top 10 plant pathogenic bacteria in molecular plant pathology

John Mansfield et al.

MOLECULAR PLANT PATHOLOGY (2012)

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Article Ecology

First observations of global and seasonal terrestrial chlorophyll fluorescence from space

J. Joiner et al.

BIOGEOSCIENCES (2011)

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Review Biochemistry & Molecular Biology

Induced plant volatiles allow sensitive monitoring of plant health status in greenhouses

Roel M. C. Jansen et al.

PLANT SIGNALING & BEHAVIOR (2009)

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Review Microbiology

Reduction of polynitroaromatic compounds: the bacterial nitroreductases

Maria Dolores Roldan et al.

FEMS MICROBIOLOGY REVIEWS (2008)

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Review Biotechnology & Applied Microbiology

Innovative tools for detection of plant pathogenic viruses and bacteria

MM Lopez et al.

INTERNATIONAL MICROBIOLOGY (2003)

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Article Biochemical Research Methods

Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method

KJ Livak et al.

METHODS (2001)

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Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor

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