期刊
ANALYTICAL CHEMISTRY
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.2c02937
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A polymer inclusion membrane (PIM) based sampling probe was developed for efficient electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dipcoating a nonconductive glass capillary tube in a homogeneous solution consisting of cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), and 1-ethyl-3methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIM][NTf2]. The developed technique demonstrated practicality and reliability in extracting doxorubicin from various biological samples, with a quantification limit of 0.2-2 ng/mL.
A polymer inclusion membrane (PIM) based sampling probe was developed for electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dipcoating a nonconductive glass capillary tube in a homogeneous PIM solution for three cycles. The PIM solution comprised cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), and 1-ethyl-3methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIM][NTf2] in a ratio of 5:4:2. The developed probe electrokinetically extracted doxorubicin from human plasma, human serum, and dried blood spot (DBS). The practicability and reliability of the electrokinetic extraction were evaluated by LC-MS/MS to quantify the desorption of extracted doxorubicin. Under the optimized conditions, a quantification limit of 0.2-2 ng/mL was achieved for the three biological samples. The probe was further integrated into a portable battery-powered device for safe low-voltage (36 V) electrokinetic extraction. The developed technique is envisioned to provide a more efficient analytical workflow in the laboratory.
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