期刊
ANALYTICAL CHEMISTRY
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.2c05043
关键词
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资金
- Key Laboratory Construction Program of Xi?an Municipal Bureau of Science and Technology
- National Postdoctoral Program for Innovative Talent
- National Natural Science Foundation of China
- Natural Science Basic Research Plan in Shaanxi Province of China
- [201805056ZD7CG40]
- [BX20190277]
- [21674085]
- [2020JZ-01]
In this study, a new type of biosensor was constructed using nanozymes, which can detect the COVID-19 virus with high sensitivity and visualization. The biosensor has the characteristics of ultrafast and ultrasensitive detection, and it can detect various variants of the SARS-CoV-2 virus.
The COVID-19 pandemic has spread to every corner of the world and seriously affected our health and daily activities in the past three years; thereby, it is still urgent to develop various simple, quick, and accurate methods for early detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) transmission. Nanozymes, a kind of nanomaterial with intrinsic enzyme-mimicking activity, have emerged as a suitable alternative for both therapy and diagnosis of SARS-CoV-2. Here, ultrasensitive and ultrafast MIL-101(CuFe)-CD147 biosensors are established for the detection of SARS-CoV-2 by a simple colorimetric method. A MIL-101(CuFe) metal-organic framework has excellent peroxidase-like activity due to the synergistic effect of Fe and Cu atoms. In addition, the MIL-101(CuFe)-CD147 biosensor shows great potential to detect the various variants of SARS-CoV-2 due to the universal receptor of CD147. The enzyme-based biosensor for the detection of SARS-CoV-2 achieves a very low limit of detection (about 3 PFU/mL) within 30 min. Therefore, the present method provides a new generation of an alternative approach for highly sensitive and visual diagnosis of COVID-19.
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