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Article
Chemistry, Analytical
Anna Blsakova et al.
Summary: This study presents the development of a novel SUspension Magnetic-Bead-based Assay (SUMBA) for the detection of antibodies against aberrant glycans (AGA) as potential cancer biomarkers. The SUMBA method was extensively optimised to achieve ultrasensitive detection of AGA with high recovery rates in serum samples.
ANALYTICA CHIMICA ACTA
(2022)
Review
Oncology
Ryan Charles Pink et al.
Summary: Expanding blood biopsy technologies like detection of circulating tumor cells and cell-free DNA show clinical promise in early cancer diagnosis. Extracellular vesicles offer a snapshot of the whole tumor, containing a complex array of molecules such as DNA, RNA, and proteins. These biomarker targets can be collected and analyzed from blood samples, showing great potential for early diagnosis.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Kiyotaka Kondo et al.
Summary: Protein N-glycosylation in lung cancer sEVs may potentially reflect the histology of lung cancers.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Biochemical Research Methods
Yeonjeong Ha et al.
Summary: During the ongoing COVID-19 pandemic, there is an urgent need for point-of-care (POC) detection methods with high sensitivity and rapid detection time. Magnetic nanoparticles (MNPs) are attractive materials that can enhance the sensitivity and reduce the detection time of conventional immunoassays. This review discusses recent advances in different types of MNPs-based immunoassays and their advantages and strategies. Furthermore, the use of MNPs for COVID-19 diagnosis through color development is also introduced, demonstrating their potential as common tools for on-site diagnosis.
Article
Biochemical Research Methods
Sha Liu et al.
Summary: This study investigated the N-glycoproteome of saliva samples for lung cancer detection and identified dysregulated site-specific glycoforms that hold promise for noninvasive detection of lung cancer.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Chemistry, Analytical
Veronika Pinkova Gajdosova et al.
Summary: This article describes the construction of a bioreceptive interface for detecting the breast cancer biomarker carbohydrate antigen CA15-3. The interface was patterned using a 2D nanomaterial MXene and a mixed layer containing sulfobetaine and carboxybetaine. An anti-CA15-3 antibody was covalently immobilized on the modified interface as a bioreceptive probe. Two different strategies for constructing an immunosensor were applied, either by blocking the interface with bovine serum albumin or without such modification. Electrochemical reading was performed using a soluble redox probe for the detection of CA15-3 in a clinically relevant range. The results show that the immunosensor based on the non-blocked interface can be used for biosensing using differential pulse voltammetry or electrochemical impedance spectroscopy, while the blocked electrode allows additional mode of action through detecting changes in the potential. Additionally, the study reveals that the redox probe used can distinguish protein molecules at different distances from the electrode.
ANALYTICA CHIMICA ACTA
(2022)
Review
Biotechnology & Applied Microbiology
Haining Li et al.
Summary: Glycans play important roles in biological systems and aberrant glycosylation can lead to disease development. Advances in glycoanalytics technologies have generated increasing amounts of glycomics data, requiring innovations for analysis. Artificial intelligence offers powerful tools for glycosylation analysis and can be used to gain insights into glycosylation machinery and the formation of glycans in different scenarios. Developing predictive AI-based models of glycosylation will provide valuable insights into glycosylation and glycan machinery.
BIOTECHNOLOGY ADVANCES
(2022)
Review
Chemistry, Multidisciplinary
Amadeo Sena-Torralba et al.
Summary: This article reviews the application of nanomaterial-based lateral flow assays (LFAs) in point-of-care diagnostics. By incorporating novel nanomaterials as signal transducers or receptor immobilization platforms, the analytical capabilities of LFAs have been improved. The article highlights strategies that can address the limitations of current LFAs and have shown commercial feasibility.
Review
Chemistry, Analytical
Tomas Bertok et al.
Summary: The review gives an overview of prostate cancer (PCa) incidence, mortality, and diagnostic methods, highlighting the need for novel biomarkers. In addition to prostate specific antigen, the review discusses alternative biomarkers available for PCa diagnostics, including low and high molecular mass biomolecules.
Review
Biochemistry & Molecular Biology
Divya Thomas et al.
Summary: Glycosylation is a crucial post-translational modification that plays a significant role in health and diseases. Aberrantly glycosylated proteins have been recognized as modulators of cancer cell phenotype, highlighting the potential of glycans as novel clinical biomarkers. The roles of glycans in tumor progression emphasize their promising target for cancer therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Biochemical Research Methods
Tomas Bertok et al.
Summary: Breast cancer is the most common cancer type in women, and novel diagnostic approaches are needed to decrease disease incidence and mortality. Research has explored cellular metabolism and altered glycosylation in breast cancer, as well as the application of glycan-based analysis in understanding the disease. Studies suggest that glycan-based biomarkers offer high accuracy for breast cancer diagnostics and patient management.
EXPERT REVIEW OF PROTEOMICS
(2021)
Review
Biotechnology & Applied Microbiology
Benjamin A. H. Smith et al.
Summary: Carbohydrates, specifically glycans, decorate every cell in the human body and most secreted proteins. Advances in genomics, glycoproteomics, and tools from chemical biology have made glycobiology more understandable and tractable. Dysregulated glycosylation plays a major role in disease processes, sparking research targeting glycans for therapeutic benefit and leading to a boom in drug development in the field.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Biochemistry & Molecular Biology
J. Sebastian Temme et al.
Summary: Carbohydrate-binding antibodies play various roles in human health, preventing infections and maintaining microbial homeostasis. While they can be beneficial in reducing infectious diseases, they may also have limitations, such as impacting blood transfusions. Vaccines and monoclonal antibodies also play a significant role in inducing anti-glycan antibodies for protection and therapeutic purposes.
BIOCHEMICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Ana Magalhaes et al.
Summary: O-glycosylation is a frequent post-translational modification of proteins with functional implications in both physiological and disease contexts. The biosynthesis depends on regulation of cellular glycosylation machinery, affecting organ-, tissue-, and cell-specific functions. Diseases triggered or modulated by aberrant O-glycosylation include genetic disorders, infectious diseases, and cancer, with potential therapeutic strategies focusing on O-glycans and their pathways.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Filip Kveton et al.
Article
Multidisciplinary Sciences
Dannielle D. Engle et al.
Review
Pathology
Anna Blsakova et al.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2019)
Review
Chemistry, Physical
Anna Blsakova et al.
CURRENT OPINION IN ELECTROCHEMISTRY
(2019)
Article
Chemistry, Physical
Marta Bukackova et al.
JOURNAL OF SOLUTION CHEMISTRY
(2018)
Review
Chemistry, Medicinal
Erika Dosekova et al.
MEDICINAL RESEARCH REVIEWS
(2017)
Review
Chemistry, Multidisciplinary
Zdenek Farka et al.
Article
Biophysics
Jaroslav Filip et al.
BIOSENSORS & BIOELECTRONICS
(2017)
Review
Biochemistry & Molecular Biology
Jennifer Munkley
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Review
Oncology
Salome S. Pinho et al.
NATURE REVIEWS CANCER
(2015)
Article
Chemistry, Physical
Vincent Goovaerts et al.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2013)
Review
Biochemical Research Methods
Tongzhong Ju et al.
PROTEOMICS CLINICAL APPLICATIONS
(2013)
Review
Biochemistry & Molecular Biology
Barbara Adamczyk et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2012)
Article
Biochemistry & Molecular Biology
Charlotte Welinder et al.
