期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 107, 期 5, 页码 992-995出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.22-0338
关键词
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资金
- CDC [U01 GH002235]
In January 2020, acute febrile illness surveillance was conducted in 11 hospitals and clinics across Belize, leading to the diagnosis of the first known case of acute Chagas infection in the country. Molecular analysis revealed a multiclonal Trypanosoma cruzi infection and the presence of Triatoma species vectors in the patient's home. The case was confirmed through seroconversion and successfully treated.
In January 2020, we instituted acute febrile illness surveillance in 11 hospitals and clinics across Belize. Within 3 months, we diagnosed an acute case of Chagas disease by polymerase chain reaction in a 7-year-old child in the northern part of the country. Phylogenetic analyses of the parasite from the acute blood specimen revealed a multiclonal Trypanosoma cruzi infection, including parasites from the TcII (25.0% of haplotypes), TcIV (2.5% of haplotypes), and TcV (72.5% of haplotypes) discrete typing units. The family reported no history of travel, and three Triatoma species vectors were found within the home. The child's mother was seronegative for antibodies to T. cruzi, ruling out congenital transmission. Convalescent blood samples documented seroconversion and confirmed acute infection. The child was successfully treated with nifurtimox. This is the first known diagnosed case of acute Chagas infection in Belize, highlighting the need for further investigation and public health prevention measures.
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