期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 23, 期 2, 页码 248-256出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajt.2022.11.004
关键词
clinical research/practice; liver transplantation/hepatology; patient survival; complication: infectious
The absolute lymphocyte count (ALC) is a surrogate marker for nutritional status and immunocompetence. This study investigates the association between ALC and post-liver transplant outcomes in deceased donor liver transplant (DDLT) patients. The results show that patients with low ALC have higher 180-day mortality, as well as increased incidence of bacteremia and cytomegaloviremia.
Absolute lymphocyte count (ALC) is considered a surrogate marker for nutritional status and immunocompetence. We investigated the association between ALC and post-liver transplant outcomes in patients who received a deceased donor liver transplant (DDLT). Patients were categorized by ALC at liver transplant: low (<500/mu L), mid (500-1000/mu L), and high ALC (>1000/mu L). Our main analysis used retrospective data (2013-2018) for DDLT recipients from Henry Ford Hospital (United States); the results were further validated using data from the Toronto General Hospital (Canada). Among 449 DDLT recipients, the low ALC group demonstrated higher 180-day mortality than mid and high ALC groups (83.1% vs 95.8% and 97.4%, respectively; low vs mid: P =.001; low vs high: P <.001). A larger proportion of patients with low ALC died of sepsis compared with the combined mid/high groups (9.1% vs 0.8%; P <.001). In multivariable analysis, pretransplant ALC was associated with 180-day mortality (hazard ratio, 0.20; P =.004). Patients with low ALC had higher rates of bacteremia (22.7% vs 8.1%; P <.001) and cytomegaloviremia (15.2% vs 6.8%; P =.03) than patients with mid/high ALC. Low ALC pretransplant through postoperative day 30 was associated with 180-day mortality among patients who received rabbit antithymocyte globulin induction (P =.001). Pretransplant lymphopenia is associated with short-term mortality and a higher incidence of posttransplant infections in DDLT patients.
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