期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 323, 期 6, 页码 H1231-H1238出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00537.2022
关键词
diabetes; glucose control; insulin resistance; obesity; vascular dysfunction
资金
- National Institutes of Health [R01HL137769, R01HL151384, R01HL153264, R21DK116081, R01HL142770]
- Veterans Affairs Merit Grant [1I01CX002399]
Insulin resistance is a hallmark of type 2 diabetes, leading to blunting of insulin-induced vasodilation. Impaired vasodilation results in reduced glucose uptake and contributes to impaired glucose control in diabetes. Understanding the mechanisms of insulin resistance is crucial for the development of diabetes and cardiovascular disease.
Insulin resistance in the vasculature is a hallmark of type 2 diabetes (T2D), and blunting of insulin-induced vasodilation is its primary consequence. Individuals with T2D exhibit a marked impairment in insulin-induced dilation in resistance arteries across vascular beds. Importantly, reduced insulin-stimulated vasodilation and blood flow to skeletal muscle limits glucose uptake and contributes to impaired glucose control in T2D. The study of mechanisms responsible for the suppressed vasodilatory effects of insulin has been a growing topic of interest for not only its association with glucose control and extension to T2D but also its relationship with cardiovascular disease development and progression. In this mini-review, we integrate findings from recent studies by our group with the existing literature focused on the mechanisms underlying endothelial insulin resistance in T2D.
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