4.7 Review

Atherosclerosis and endothelial mechanotransduction: current knowledge and models for future research

期刊

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 324, 期 2, 页码 C488-C504

出版社

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00449.2022

关键词

atherosclerosis; endothelial cell glycocalyx; mechanotransduction; shear stress; stiffness

向作者/读者索取更多资源

Endothelium health is crucial for regulating physiological vascular functions. Dysfunction of endothelial cells (ECs) is associated with various vascular diseases, especially atherosclerosis and cardiovascular diseases. This review discusses mechanotransduction events mediated by ECs, the involved subcellular components, and potential pathways. It also reviews current research efforts using in vivo animal models and in vitro biomimetic models, along with recommendations for future modeling approaches to aid the development of novel therapies targeting atherosclerosis and related cardiovascular diseases.
Endothelium health is essential to the regulation of physiological vascular functions. Because of the critical capability of endothe-lial cells (ECs) to sense and transduce chemical and mechanical signals in the local vascular environment, their dysfunction is associated with a vast variety of vascular diseases and injuries, especially atherosclerosis and subsequent cardiovascular dis-eases. This review describes the mechanotransduction events that are mediated through ECs, the EC subcellular components involved, and the pathways reported to be potentially involved. Up-to-date research efforts involving in vivo animal models and in vitro biomimetic models are also discussed, including their advantages and drawbacks, with recommendations on future mod-eling approaches to aid the development of novel therapies targeting atherosclerosis and related cardiovascular diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据