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Comment on: Personalized Model to Predict Keratoconus Progression From Demographic, Topographic, and Genetic Data

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Article Ophthalmology

Personalized Model to Predict Keratoconus Progression From Demographic, Topographic, and Genetic Data

Howard p. Maile et al.

Summary: The study aimed to develop a prognostic model to predict keratoconus progression to corneal crosslinking (CXL) and found that CXL provided a stronger predictive model than keratometric progression. Age and keratometry were significant predictors of progression risk, while candidate SNPs associated with keratoconus did not contribute to progression risk.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2022)

Article Ophthalmology

Heritability of Corneal Parameters in Nuclear Families With Keratoconus

Yawen Wang et al.

Summary: This study investigated the heritability of corneal parameters in nuclear families with keratoconus (KC), and found that pachymetric indices are heritable and may be a corneal characteristic to predict the occurrence of KC.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2022)

Article Ophthalmology

Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus

Yaron S. Rabinowitz et al.

Summary: Keratoconus is a complex disease influenced by both genetic and environmental factors, with eye rubbing and sleeping position compression playing a significant role. Genetic factors and mechanical trauma are believed to be key in the development of the condition.

EXPERIMENTAL EYE RESEARCH (2021)