Gender Differences in Age-Stratified Early Outcomes in Patients With Transcatheter Aortic Valve Implantation

Few researchers have discussed the differences in gender between the age groups of patients who underwent transcatheter aortic valve implantation (TAVI). We searched the National Readmissions Database from 2012 to 2019 to identify adults who underwent TAVI. We studied hospital outcomes and short-to medium-term outcomes by age stratification (18 to 59, 60 to 69, 70 to 79, and 80 to 90 years) after TAVI and categorized by gen-der. We included 147,481 patients who underwent TAVI, and 54,802 pairs were matched using propensity score matching separately for each age group. Compared with men, women in all age groups had a similar rate of hospital death. Except the 18-to 59-year-old groups, female patients were less likely to undergo permanent pacemaker implantation and transfusion. Records of readmission at 30 days and 6 months were used as the follow-up outcome according to the presence or absence of readmission. Major adverse cardio-vascular events (MACEs) were a composite of cardiovascular readmission, all-cause mortality during readmission, and stroke readmission. At the 30-day follow-up visit, there was no difference in the all-cause readmission and MACE between women and men in any group. At the 6-month follow-up visit, women in the 70-to 79-year-old and 80-to 90-year -old groups had a high risk of all-cause readmission. In conclusion, we reported that female patients have similar in-hospital death rates to male patients who underwent TAVI. During the 30-day follow-up visit, the all-cause readmission and MACE were not different in all age groups between men and women. At 6 months, women in the 70-to 79-year-old and 80-to 90-year-old groups had a higher risk of all-cause readmission. (C) 2022 The Author (s). Published by Elsevier Inc.

Automated summary

This study examined the gender and age differences in patients who underwent transcatheter aortic valve implantation (TAVI). The results showed that female patients had similar in-hospital death rates as male patients, and at the 30-day and 6-month follow-up visits, there was no difference in all-cause readmission and major adverse cardiovascular events (MACE) between men and women in most age groups, except for women aged 18 to 59 who were less likely to undergo pacemaker implantation and transfusion. However, women in the 70 to 79 and 80 to 90 age groups had a higher risk of all-cause readmission at the 6-month follow-up.