期刊
JOURNAL OF NEUROINFLAMMATION
卷 13, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s12974-016-0633-4
关键词
Matrix metalloproteinases; Neurodegenerative disease; Trafficking; Neuroinflammation; IL-1 beta; Amyloidogenesis; Amyloid precursor protein
资金
- CNRS
- Aix-Marseille Universite
- French National Agency for Research (ANR)
- LECMA
- France Alzheimer
- French Fondation Plan Alzheimer
- Aix-Marseille Universite A*MIDEX
We have recently identified in a transgenic mouse model of Alzheimer's disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer's pathogenesis, which displays pro-amyloidogenic features and proteolytic processing of amyloid precursor protein (APP). Another group has reported that MT5-MMP processing of APP may release a novel neurotoxic APP fragment. Although MT5-MMP-mediated APP processing appears to be a key pathogenic step, we hypothesize that MT5-MMP may also contribute to AD pathogenesis through complementary mechanisms that involve the activation of pro-inflammatory pathways and/or APP trafficking.
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