期刊
ALZHEIMERS & DEMENTIA
卷 19, 期 5, 页码 2034-2046出版社
WILEY
DOI: 10.1002/alz.12867
关键词
Alzheimer's disease; functional magnetic resonance imaging; network segregation; tau spreading; tau positron emission tomography
This study found that lower network segregation is associated with accelerated cognitive decline in Alzheimer's disease. Furthermore, the degree of network segregation is related to the speed of tau protein spreading in the brain.
IntroductionLower network segregation is associated with accelerated cognitive decline in Alzheimer's disease (AD), yet it is unclear whether less segregated brain networks facilitate connectivity-mediated tau spreading. MethodsWe combined resting state functional magnetic resonance imaging (fMRI) with longitudinal tau positron emission tomography (PET) in 42 betamyloid-negative controls and 81 amyloid beta positive individuals across the AD spectrum. Network segregation was determined using resting-state fMRI-assessed connectivity among 400 cortical regions belonging to seven networks. ResultsAD subjects with higher network segregation exhibited slower brain-wide tau accumulation relative to their baseline entorhinal tau PET burden (typical onset site of tau pathology). Second, by identifying patient-specific tau epicenters with highest baseline tau PET we found that stronger epicenter segregation was associated with a slower rate of tau accumulation in the rest of the brain in relation to baseline epicenter tau burden. DiscussionOur results indicate that tau spreading is facilitated by a more diffusely organized connectome, suggesting that brain network topology modulates tau spreading in AD. HighlightsHigher brain network segregation is associated with attenuated tau pathology accumulation in Alzheimer's disease (AD).A patient-tailored approach allows for the more precise localization of tau epicenters.The functional segregation of subject-specific tau epicenters predicts the rate of future tau accumulation.
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