☆ 4.7 Article

Amyloid futures in the expanding pathology of brain aging and dementia

ALZHEIMERS & DEMENTIA (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Geriatrics & Gerontology

Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer's Disease: A Focus on Aducanumab and Lecanemab

Mingchao Shi et al.

Summary: Alzheimer's disease is the most prevalent form of age-related dementia in the world, with limited treatment options available to provide only partial symptomatic relief. Disease-modifying therapies, targeting the systemic failure of cell-mediated Aβ clearance, are currently being studied in clinical trials.

FRONTIERS IN AGING NEUROSCIENCE (2022)

添加到收藏夹

Article Immunology

Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention

Kevin D. Rynearson et al.

Summary: The potent gamma-secretase modulator has shown robust time- and dose-dependent efficacy in animal studies, with a >40-fold safety margin in rats.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis

Sarah F. Ackley et al.

Summary: Pooled evidence from 14 randomized controlled trials targeting amyloid mechanism suggests that reducing amyloid levels does not substantially improve cognition.

BMJ-BRITISH MEDICAL JOURNAL (2021)

添加到收藏夹

Article Clinical Neurology

To what degree is late life cognitive decline driven by age-related neuropathologies?

Patricia A. Boyle et al.

Summary: The study found that cognitive decline in old age is driven by a wide array of neuropathologies, with Alzheimer's disease, infarcts, non-Alzheimer's disease neurodegenerative diseases, and cerebrovascular conditions playing significant roles. While most pathological indices were associated with faster decline, they only accounted for a portion of the variation in decline, highlighting the complexity of cognitive ageing.

BRAIN (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Regulation of beta-amyloid production in neurons by cholesterol

Hao Wang et al.

Summary: The study shows that apoE uses astrocyte-derived cholesterol to traffic neuronal APP in and out of lipid clusters, generating A beta peptide. Deletion of astrocyte cholesterol synthesis reduces amyloid and tau burden in a mouse model of AD, indicating that cholesterol is kept low in neurons and astrocytes regulate A beta accumulation through cholesterol signaling.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Clinical Neurology

The development and convergence of co-pathologies in Alzheimer's disease

John L. Robinson et al.

Summary: This study found that CAA, LATE-NC, and Lewy bodies are common pathologies in Alzheimer's disease that worsen in severity as the disease progresses. Age was associated with all pathologies, while the APOE epsilon 4 gene was specifically linked to CAA. In individuals with dementia, age was linked to LATE-NC, while Lewy bodies were more common in younger patients.

BRAIN (2021)

添加到收藏夹

Article Clinical Neurology

Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019

David S. Knopman et al.

Summary: Aducanumab recently underwent two large phase III clinical trials that were stopped prematurely by the sponsor due to divergent outcomes. One trial showed potential benefits from high doses of Aducanumab, while the other did not show any benefits. Further analysis is needed to determine the true efficacy as a treatment for Alzheimer's disease.

ALZHEIMERS & DEMENTIA (2021)

添加到收藏夹

Review Neurosciences

Clusterin in Alzheimer's Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

Evangeline M. Foster et al.

FRONTIERS IN NEUROSCIENCE (2019)

添加到收藏夹

Article Neurosciences

Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer's Disease Status and Risk Genotype

Erica Lana et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting

Robert Kisilevsky et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2016)

添加到收藏夹

Article Neurosciences

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

Axel Montagne et al.

NEURON (2015)

添加到收藏夹

Article Psychology, Multidisciplinary

When Does Cognitive Functioning Peak? The Asynchronous Rise and Fall of Different Cognitive Abilities Across the Life Span

Joshua K. Hartshorne et al.

PSYCHOLOGICAL SCIENCE (2015)

添加到收藏夹

Review Geriatrics & Gerontology

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease

Takahisa Kanekiyo et al.

FRONTIERS IN AGING NEUROSCIENCE (2014)

添加到收藏夹

Review Clinical Neurology

Amyloid beta-protein oligomers and Alzheimer's disease

Eric Y. Hayden et al.

ALZHEIMERS RESEARCH & THERAPY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

Jie Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

添加到收藏夹

Article Biochemical Research Methods

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

Katherine Lynn Youmans et al.

JOURNAL OF NEUROSCIENCE METHODS (2011)

添加到收藏夹

Article Neurosciences

Age-related changes in processing speed: unique contributions of cerebellar and prefrontal cortex

Mark A. Eckert et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2010)

添加到收藏夹

Article Clinical Neurology

Amyloid Deposition and Influx Transporter Expression at the Blood-Brain Barrier Increase in Normal Aging

Gerald D. Silverberg et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

The neurobiology of middle-age has arrived

Caleb E. Finch

NEUROBIOLOGY OF AGING (2009)

添加到收藏夹

Article Neurosciences

Age-related changes in serum and brain levels of androgens in male Brown Norway rats

Emily R. Rosario et al.

NEUROREPORT (2009)

添加到收藏夹

Article Pathology

β-secretase activity increases with aging in human, monkey, and mouse brain

H Fukumoto et al.

AMERICAN JOURNAL OF PATHOLOGY (2004)

添加到收藏夹

Review Biochemistry & Molecular Biology

Review: History of the amyloid fibril

JD Sipe et al.

JOURNAL OF STRUCTURAL BIOLOGY (2000)

添加到收藏夹

Article Medicine, General & Internal

Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline

J Näslund et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.