期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 293, 期 -, 页码 100-104出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.03.004
关键词
IL-12; IL-27; IL-35; Neuromyelitis optica spectrum disorders (NMOSD)
资金
- Tianjin Research Program of Application Foundation and Advanced Technology [15JCZDJC35700]
- National Science Foundation of China [81471221, 81171183]
- National Key Clinical Specialty Construction Project of China
The interleukin 12 (IL-12) family plays important roles in autoimmune diseases. To explore the roles of the IL-12 family members IL-27 and IL-35 in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD), we determined their serum and cerebral spinal fluid levels and assessed potential correlations with clinical characteristics. Serum IL-27 levels were negatively correlated with disease severity and spinal cord lesion length, while serum IL-35 levels were negatively correlated with disease severity and annual relapse rate. Thus, IL-27 and IL-35 may be important biomarkers of NMOSD severity and these molecules might represent potential therapeutic cytokines for treating NMOSD. (C) 2016 Elsevier B.V. All rights reserved.
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