期刊
ALLERGY
卷 78, 期 6, 页码 1628-1638出版社
WILEY
DOI: 10.1111/all.15645
关键词
adrenaline; anaphylaxis; death; food; mortality
A retrospective analysis was conducted on severe anaphylaxis cases recorded by the Allergy-Vigilance (R) Network (2002-2020) to evaluate the characteristics associated with survival, age, and allergens. The results showed that food was the main allergen for severe anaphylaxis in both children and adults, and young age, asthma history, and exercise were characteristic features of severe food anaphylaxis.
BackgroundHaving a better understanding of the risk factors of severe anaphylaxis is a crucial challenge for physicians. MethodsTo retrospectively analyse fatal/near-fatal anaphylaxis cases recorded by the Allergy-Vigilance (R) Network (2002-2020) and evaluate the characteristics associated with survival, age and allergens. ResultsAmong the 3510 anaphylaxis cases documented in the network, 70 (2%) patients (males: 57%; mean age: 35.4 y) presented grade 4 (Ring-Messmer) anaphylaxis and 25 died (19 food-related); 33% had a history of asthma. The main allergens were food (60%; peanut, 20%; milks, 11%) involved in 25/26 cases in children and in 17/44 (39%) cases in adults. Non-food anaphylaxis was related to drugs/latex (24%; neuromuscular blocking agents, 10%; betalactamins, 6%), Hymenoptera (16%). Three food-related cases (one death) occurred during oral food challenge in children. Patients with a food allergy were younger (22.2 years vs. 55 years, p < .001), had more likely a history of asthma (50% vs. 7%; p < .001), a pre-existing allergy (62% vs. 18%; p < .001) compared with other allergies. A cofactor was identified in 35 cases (50%) but predominantly in adults as opposed to children (64% vs. 27%; p = .01). The patients who died were younger (25.6 vs. 40.8 years; p = .01) than the survivors and mostly presented bronchospasm (56% vs. 29%; p = .05). Gaps in the prevention and management of anaphylaxis were noted in 15 cases (21%). ConclusionsSevere food anaphylaxis has specific features compared with other causes such as young age, asthma history and exercise. Food is also involved in severe anaphylaxis in adults that should not be underestimated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据