4.7 Article

Randomised clinical trial: effects of MD-7246 on irritable bowel syndrome with diarrhoea

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Gastroenterology & Hepatology

Placebo Response Rates in Trials of Licensed Drugs for Irritable Bowel Syndrome With Constipation or Diarrhea: Meta-analysis

Brigida Barberio et al.

Summary: This study assessed the placebo response rates of licensed drugs for irritable bowel syndrome and found that adhering to FDA-recommended endpoints can lower placebo response rates. However, further refinement of some of these endpoints may be needed to better differentiate between active drug and placebo.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Diarrhea

Anthony Lembo et al.

Summary: This article presents medication management guidelines for irritable bowel syndrome (IBS). The guidelines provide 8 recommendations for the pharmacological treatment of IBS-D patients, and evaluate the evidence and certainty of different medications.

GASTROENTEROLOGY (2022)

Article Gastroenterology & Hepatology

Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

Ami D. Sperber et al.

Summary: FGIDs have a high prevalence globally, especially among women. Individuals with FGIDs experience lower quality of life and require more frequent medical visits. The proportion of irritable bowel syndrome patients diagnosed using the Rome IV criteria is lower compared to the Rome III criteria.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Randomized Trial of 2 Delayed-Release Formulations of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

William D. Chey et al.

Summary: The study demonstrates that the delayed-release formulation of linaclotide and MD-7246 show better improvement in abdominal pain compared to placebo. MD-7246 shows sustained but modest effects on pain relief, suggesting further investigation as a novel treatment for abdominal pain.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

ACG Clinical Guideline: Management of Irritable Bowel Syndrome

Brian E. Lacy et al.

Summary: Irritable bowel syndrome (IBS) is a chronic disorder that significantly impacts patients' quality of life. The American College of Gastroenterology has developed a clinical guideline using GRADE methodology for the management of IBS, recommending a positive diagnostic approach, specific tests, treatments, and gut-directed psychotherapy to improve symptoms for patients with IBS.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System

Lin Chang et al.

Summary: Linaclotide significantly improved abdominal symptoms related to constipation-predominant irritable bowel syndrome (IBS-C) compared to placebo, including bloating, discomfort, and pain. The study found that linaclotide had a higher overall change from baseline in abdominal score (AS) and a higher responder rate for abdominal symptoms improvement, with diarrhea being the most common side effect. The use of a novel multi-item AS derived from the Diary for IBS Symptoms-Constipation may be valuable in future clinical studies for IBS-C to measure meaningful improvements beyond traditional endpoints.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Review Gastroenterology & Hepatology

The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis

Michelle Bosman et al.

Summary: The study found that continuing infliximab treatment in patients with ulcerative colitis resulted in a higher remission rate compared to discontinuing the treatment. Adverse events were similar between the two groups. Patients who relapsed and were re-treated with infliximab achieved remission without infusion reactions.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Gastroenterology & Hepatology

Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis

Priya Oka et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Medicine, General & Internal

Functional Gastrointestinal Disorders 2 Irritable bowel syndrome

Alexander C. Ford et al.

LANCET (2020)

Review Psychiatry

Placebo Responses and Placebo Effects in Functional Gastrointestinal Disorders

Paul Enck et al.

FRONTIERS IN PSYCHIATRY (2020)

Article Gastroenterology & Hepatology

Effects of Irritable Bowel Syndrome on Daily Activities Vary Among Subtypes Based on Results From the IBS in America Survey

Sarah Ballou et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

Review Physiology

Visceral Pain

Luke Grundy et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)

Article Gastroenterology & Hepatology

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome

Alexander C. Ford et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

Factors Associated With Response to Placebo in Patients With Irritable Bowel Syndrome and Constipation

Sarah Ballou et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Health Care Sciences & Services

Health-related quality of life, work productivity, and indirect costs among patients with irritable bowel syndrome with diarrhea

Jessica L. Buono et al.

HEALTH AND QUALITY OF LIFE OUTCOMES (2017)

Article Gastroenterology & Hepatology

Eluxadoline Efficacy in IBS-D Patients Who Report Prior Loperamide Use

Brian E. Lacy et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV

Douglas A. Drossman

GASTROENTEROLOGY (2016)

Article Gastroenterology & Hepatology

Bowel Disorders

Brian E. Lacy et al.

GASTROENTEROLOGY (2016)

Article Gastroenterology & Hepatology

Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation

Satish S. C. Rao et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

Placebo Effect in Clinical Trial Design for Irritable Bowel Syndrome

Eric Shah et al.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2014)

Article Gastroenterology & Hepatology

Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes

Patrick A. Hughes et al.

Article Medicine, General & Internal

Two Randomized Trials of Linaclotide for Chronic Constipation

Anthony J. Lembo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Gastroenterology & Hepatology

Meta-analysis: factors affecting placebo response rate in the irritable bowel syndrome

A. C. Ford et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2010)

Article Gastroenterology & Hepatology

Placebo responses in patients with gastrointestinal disorders

Frauke Musial et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2007)

Review Gastroenterology & Hepatology

Defining the predictors of the placebo response in irritable bowel syndrome

M Pitz et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2005)