期刊
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
卷 47, 期 1, 页码 36-44出版社
WILEY
DOI: 10.1111/acer.14979
关键词
alcohol use disorder; immunity; inflammation; multi-organ dysfunction
This critical review describes the potential mechanisms by which alcohol misuse leads to immune system dysfunction and highlights the current research gaps.
Alcohol misuse contributes to the dysregulation of immune responses and multiorgan dysfunction across various tissues, which are associated with higher risk of morbidity and mortality in people with alcohol use disorders. Organ-specific immune cells, including microglia in the brain, alveolar macrophages in the lungs, and Kupffer cells in the liver, play vital functions in host immune defense through tissue repair and maintenance of homeostasis. However, binge drinking and chronic alcohol misuse impair these immune cells' abilities to regulate inflammatory signaling and metabolism, thus contributing to multiorgan dysfunction. Further complicating these delicate systems, immune cell dysfunction associated with alcohol misuse is exacerbated by aging and gut barrier leakage. This critical review describes recent advances in elucidating the potential mechanisms by which alcohol misuse leads to derangements in host immunity and highlights current gaps in knowledge that may be the focus of future investigations.
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