期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 298, 期 -, 页码 51-57出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2016.07.001
关键词
Myasthenia gravis; Thymoma; Titin antibodies; Ryanodine receptor antibodies; Muscle-specific kinase antibodies
资金
- Torbjorg Hauges' Legacy
- National Natural Science Foundation of China [81070963]
- Natural Science Foundation of Shandong Province [ZR2010HM019]
Myasthenia gravis (MG) is an autoimmune disorder with heterogeneity. Antibodies against acetylcholine receptor (AChR), muscle-specific kinase (MuSK), titin and ryanodine receptor (RyR) were examined in 437 adult Chinese MG patients. The AChR, MuSK, titin and RyR antibodies were found in 82.2%, 2.3%, 28.4% and 23.8% of all patients. Autoantibody profiles vary among different MG subgroups. Thymoma MG patients had high frequencies of AChR (99.2%), titin (50.8%) and RyR antibodies (46.9%).The titin and RyR antibodies also showed high frequencies in late onset patients (54.4% and 33.3%, respectively). These two antibodies may indicate an underlying thymoma when combined. The patients with titin and RyR antibodies tend to have more severe disease and worse outcome, and may need more active immunosuppressive treatment. (C) 2016 Elsevier B.V. All rights reserved.
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