期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 293, 期 -, 页码 86-90出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.02.016
关键词
Parkinson's disease; ZnT proteins; Autoimmunity; MAP; Antigenic peptides
资金
- Sardinian Region L.R.7, Progetti di ricerca di base
In Parkinson's disease (PD) ZnT proteins play an important role. Zinc is a co-factor of numerous enzymes and stabilizes the tertiary structure of several proteins. Nothing is known about previous infections mediated by Mycobacterium avium subsp. paratuberculosis (MAP). We evaluated if a previous infection with MAP could induce the production of antibodies that cross-reacted with the Znt homologous antigenic peptides associated to Parkinson. The humoral response toward MAP3865c peptides, ZnT3 and ZnT10 was evaluated. The hypothesis of cross reactivity needs to be confirmed: we have observed the presence of MAP in PD patients by PCR, positivity to MAP3865c peptides, therefore MAP infection but not cross-reaction with human homologous Znt proteins. (C) 2016 Elsevier B.V. All rights reserved.
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