期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 297, 期 -, 页码 38-45出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.05.004
关键词
Neuromuscular junction disorders; Immune regulation; Bregs; IL-10; Cytokines; B cells
资金
- Muscular Dystrophy Association (MDA Grant) [234223]
- pilot grant from Myasthenia Gravis Foundation of Illinois
- Alexander Corey Memorial Fund
Regulatory B cells (Bregs) attenuate the severity of experimental autoimmune myasthenia gravis (EAMG) in an interleukin-10 (IL-10)-dependent manner. The goal of this study was to investigate the role of human Bregs in MG focusing on CD19(+)CD1d(hi) CD5(+) and CD19(+)CD24(hi)CD38(hi) subsets. We found that MG patients exhibited a decrease in the frequency of both Breg subsets and IL-10 producing B cells within each subset, which correlated with disease severity. In addition, there was impaired suppression of Th1 polarization in MG. These findings, taken together with EAMG data, indicate that Bregs play an important role in regulating the severity of MG. (C) 2016 Elsevier B.V. All rights reserved.
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