期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 292, 期 -, 页码 1-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.01.005
关键词
leucine-rich repeat kinase 2; B1 cell; B2 cell; B cell receptor signaling; IgA; TI antigen
资金
- Kitasato University School of Allied Health Sciences [18-1]
- Grants-in-Aid for Scientific Research [15H01565, 15K06777] Funding Source: KAKEN
LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRIC mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRICknockout (LRRK2(-/-)) mice. LRRK2(-/-) mice had significantly higher counts of peritoneal B1 cells than wild-type mice. After BCR stimulation, phosphor-Erk1/2 of splenic B2 cells was enhanced to a higher degree in LRRK2(-/-) mice. LRRK2(-/-) mice had a significantly higher serum IgA level, and TNP-Ficoll immunization increased the titer of serum anti-TNP IgM antibody. LRRK2(-/-) may play important roles in B cells. (C) 2016 Elsevier B.V. All rights reserved.
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