Arterial myogenic response and aging

The arterial myogenic response is an inherent property of resistance arteries. Myogenic tone is crucial for maintaining a relatively constant blood flow in response to changes in intraluminal pressure and protects delicate organs from excessive blood flow. Although this fundamental physiological phenomenon has been extensively studied, the underlying molecular mechanisms are largely unknown. Recent studies identified a crucial role of mechano-activated angiotensin II type 1 receptors (AT1R) in this process. The development of myogenic response is affected by aging. In this review, we summarize recent progress made to understand the role of AT1R and other mechanosensors in the control of arterial myogenic response. We discuss age-related alterations in myogenic response and possible underlying mechanisms and implications for healthy aging.

Automated summary

The arterial myogenic response is a critical mechanism in maintaining constant blood flow and protecting delicate organs. The activation of mechanosensors, such as angiotensin II type 1 receptors (AT1R), plays a crucial role in this process. Aging affects the development of myogenic response. This review summarizes recent progress in understanding the role of AT1R and other mechanosensors in arterial myogenic response, along with the implications for healthy aging.