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Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
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The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
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CELL DEATH & DISEASE (2010)
Phase II Trial of CoQ10 for ALS Finds Insufficient Evidence to Justify Phase III
Petra Kaufmann et al.
ANNALS OF NEUROLOGY (2009)
Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis
Lana Kupershmidt et al.
FASEB JOURNAL (2009)
Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process
Stefania Mantovani et al.
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Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis
Suh Young Jeong et al.
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Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer's Disease
Cristina Rodriguez-Rodriguez et al.
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Interactions between riluzole and ABCG2/BCRP transporter
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A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease
C. Warren Olanow et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats
Hiroaki Obata et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)
R(+) pramipexole as a mitochondrially focused neuroprotectant: Initial early phase studies in ALS
Hua Wang et al.
AMYOTROPHIC LATERAL SCLEROSIS (2008)
Creatine monohydrate in ALS: Effects on strength, fatigue, respiratory status and ALSFRS
Jeffrey Rosenfeld et al.
AMYOTROPHIC LATERAL SCLEROSIS (2008)
Motoneuronotrophic factor analog GM6 reduces infarct volume and behavioral deficits following transient ischemia in the mouse
Jin Yu et al.
BRAIN RESEARCH (2008)
Withaferin A inhibits NOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-κB in RAW 264.7 cells
Jung Hwa Oh et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Mitochondrial dysfunction in S0D1G93A-bearing astrocytes promotes motor neuron degeneration:: Prevention by mitochondrial-targeted antioxidants
Patricia Cassina et al.
JOURNAL OF NEUROSCIENCE (2008)
c-Rel, an NF-κB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation
Hyung Jin Ahn et al.
LEARNING & MEMORY (2008)
Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease
G. Nagesh Babu et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
An analysis of the entire SOD1 gene in sporadic ALS
Natasha Luquin et al.
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Selective assoction of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria
Christine Vande Velde et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
Paul H. Gordon et al.
LANCET NEUROLOGY (2007)
Toll-like receptors modulate adult hippocampal neurogenesis
Asya Rolls et al.
NATURE CELL BIOLOGY (2007)
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
Thierry Bordet et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis
Susanne Petri et al.
JOURNAL OF NEUROCHEMISTRY (2007)
High erythropoletin and low vascular endothelial growth factor levels in cerebrospinal fluid from hypoxemic ALS patients suggest an abnormal response to hypoxia
N. Just et al.
NEUROMUSCULAR DISORDERS (2007)
Mitochondria and neuronal activity
Oliver Kann et al.
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Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice
Yaoming Wang et al.
JOURNAL OF NEUROSCIENCE (2007)
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
Sian C. Barber et al.
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The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes
Juan C. Chavez et al.
JOURNAL OF NEUROSCIENCE (2006)
Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials
Alberto Ferri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors
KJ O'Riordan et al.
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Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
HX Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Paradoxical response of VEGF expression to hypoxia in CSF of patients with ALS
C Moreau et al.
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Targeted antioxidative and neuroprotective properties of the dopamine agonist pramipexole and its nondopaminergic enantiomer SND919CL2x [(+)2-amino-4,5,6,7-tetrahydro-6-L-propylamino-benzathiazole dihydrochloride]
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Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases:: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition
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JOURNAL OF NEUROCHEMISTRY (2005)
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion
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JOURNAL OF NEUROCHEMISTRY (2005)
Signaling via NF-κB in the nervous system
B Kaltschmidt et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)
High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study
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JOURNAL OF NEURAL TRANSMISSION (2005)
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice
C Vijayvergiya et al.
JOURNAL OF NEUROSCIENCE (2005)
Clinical trials of coenzyme Q(10) in neurological disorders
Clifford W. Shults et al.
BIOFACTORS (2005)
Shaping the nuclear action of NF-κB
LF Chen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-Rel
JM Levenson et al.
JOURNAL OF NEUROSCIENCE (2004)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis:: an [11C](R)-PK11195 positron emission tomography study
MR Turner et al.
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Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model
S Waibel et al.
JOURNAL OF NEUROLOGY (2004)
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
J Liu et al.
NEURON (2004)
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
P Pasinelli et al.
NEURON (2004)
Effects of coenzyme Q10 in early Parkinson disease -: Evidence of slowing of the functional decline
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ARCHIVES OF NEUROLOGY (2002)
Mitochondrial involvement in amyotrophic lateral sclerosis
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Immune reactivity in a mouse model of familial ALS correlates with disease progression
ME Alexianu et al.
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Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis
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Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
B Oosthuyse et al.
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Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation
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Mitochondria and neuronal survival
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