期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 301, 期 -, 页码 41-48出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.10.009
关键词
Biomarkers; Inflammation; HIV-associated neurocognitive disorders; HIV-1; Subtype; Cerebrospinal fluid; Blood-CSF barrier
资金
- National Institutes of Health, NIH [R21 MH76651, R01 MH83552, S10 RR31646, K24 MH097673]
- University of California, San Diego
- Center for AIDS Research (CFAR), an NIH [P30 AI036214]
- NIAID
- NCI
- NIMH [P30MH062512]
- NIDA
- NICHD
- NHLBI
- NIA
- NIGMS
- NIDDK
- Ministerio da Ciencia e Tecnologia/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, MCT/CNPq-Universal, Brazil [014/2008]
HIV infection is persistent in the CNS, to evaluate the compartmentalization of the CNS immune response to HIV, we compared soluble markers of cellular immunity in the blood and CSF among HIV - (n = 19) and HIV+ (n = 68), as well as among HIV participants with or without CSF pleocytosis. Dysfunction of the blood cerebrospinal fluid barrier (BCSFB) was common in HIV participants. CSF levels of TNF alpha, IFN gamma, IL-2, IL-6, IL-7, IL-10, IP-10, MIP-1 alpha, MIP-1 beta, and RANTES were significantly higher in participants with CSF pleocytosis (P < 0.05); serum levels of these biomarkers were comparable. The CNS immune response is compartmentalized, and remains so despite the BCSFB dysfunction during HIV infection; it is markedly reduced by virology suppression, although BCSFB dysfunction persists on this subgroup. (C) 2016 Elsevier B.V. All rights reserved.
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