期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 298, 期 -, 页码 138-145出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2016.07.016
关键词
Astilbin; Experimental autoimmune myasthenia gravis; Th cells; Th17 cells; MHC class II
资金
- Natural Science Foundation of Shandong Province [ZR2010HM068]
Astilbin, a major bioactive compound extracted from Rhizoma smilacis glabrae (RSG), has been reported to possess immunosuppressive properties. Our study first evaluated the effect of astilbin on experimental autoimmune myasthenia gravis (EAMG) in Lewis rats. The results showed that astilbin could attenuate the severity of EAMG by decreasing antigen-specific autoantibodies with up-regulation of regulatory T cells and down-regulation of Th17 cells. In addition to, astilbin also reduced the.efficiency of the antigen presenting cells on which the expression of MHC class II decreased. These results suggest that astilbin might be a candidate drug for immunoregulation of EAMG, and provide us new treatment ideas for human myasthenia gravis (MG). (C) 2016 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据