期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 297, 期 -, 页码 56-62出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.05.012
关键词
Multiple sclerosis; Clinically isolated syndrome; Epstein-Barr virus; Epstein-Barr nuclear antigen; Antibodies; Peptide microarray
资金
- Deutsche Forschungsgemeinschaft [DFG Exc 257]
- German Ministry of Education and Research (BMBF/KKNMS, Competence Network Multiple Sclerosis)
We analyzed the fine specificity of antibodies to Epstein-Barr nuclear antigen-2 (EBNA-2) and other Epstein-Barr virus (EBV) proteins in 29 patients with clinically isolated syndrome (CIS, the first clinical manifestation of multiple sclerosis [MS]) and 29 controls with a peptide microarray containing 117 overlapping peptides representing the full-length EBNA-2 protein and 71 peptides from 8 further EBV proteins. While EBV peptide antibodies were elevated in CIS, suggesting that EBV contributes to MS early during disease development, they discriminated groups only slightly better than EBNA-1 antibodies. Thus, the additional value of EBV peptide antibodies as diagnostic biomarlcers for CIS appears moderate. (C) 2016 Elsevier B.V. All rights reserved.
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