期刊
AFRICAN HEALTH SCIENCES
卷 22, 期 3, 页码 62-71出版社
MAKERERE UNIV, COLL HEALTH SCIENCES,SCH MED
DOI: 10.4314/ahs.v22i3.8
关键词
Chlamydia trachomatis; Neisseria gonorrhoeae; Prevalence; Antimicrobial resistance; Genomic Analysis; Sexual partner networks
资金
- Office Of The Director, National Institutes Of Health (OD) [D43TW010132]
- National Institute Of Dental & Craniofacial Research (NIDCR)
- National Institute Of Neurological Disorders And Stroke (NINDS)
- National Heart, Lung, And Blood Institute (NHLBI)
- Fogarty International Center (FIC)
- National Institute On Minority Health And Health Disparities (NIMHD)
- National Institute On Aging
- Fogarty International Center of the National Institutes of Health [D43 TW010037]
- [U54EB007958-13]
Sexually transmitted diseases (STDs) management in sub-Saharan Africa is typically based on syndromic diagnosis, but molecular diagnostics can provide faster and more sensitive diagnosis and treatment. This study assessed the feasibility of using the Xpert CT/NG test to identify prevalent Chlamydia trachomatis (CT) and Neisseria gonorrhea (NG) infections among STD clinic attendees and their sexual partners, and tested for antimicrobial resistance for N. gonorrhea. The findings showed a high prevalence of NG, particularly among men, and a significant proportion of dual infections. The study highlights the importance of partner tracing and treatment to effectively control CT/NG in this population.
Background: Sexually transmitted diseases (STDs) management in sub-Saharan Africa is syndromic but molecular diagnostics provide quicker, sensitive diagnosis and treatment. Effective STD control hinges on identification and treatment of infected persons and sexual partner contact tracing. Objectives: This study assessed feasibility of using the Xpert CT/NG test to identify prevalent Chlamydia trachomatis (CT) and Neisseria gonorrhea (NG) infections among STD clinic attendees and their sexual partners and tested for antimicrobial resistance for N. gonorrhea. Methods: A cross-sectional study was conducted at 4 outpatient STD clinics in Kampala, Uganda from February 2019 to October 2019. Participants received a syndromic diagnosis, were tested for NG and CT, as well as their sexual partners. Urine (men) and high vaginal swabs (women) were collected, examined using Xpert CT/NG assay. A total of 79 participants were enrolled at baseline of whom 25 had CT/NG. 21 partners of infected baseline participants and 7 partners of the 21 primary partners were enrolled. Results: The mean age of the reported sexual partners was 26 (18-43) years. The prevalence of NG was 25% at baseline and 18 % for CT. Nine (11.4%) people were dually infected. Men were more likely to have NG (p<0.001) at multivariable level. Two participants tested HIV-1 positive. On microbiological culture, 8 samples (2.5%) grew NG and all were resistant to penicillin, ciprofloxacin. For CT, we found a preponderance of the F-serovar in this population. Conclusion: The most prevalent organism was Neisseria gonorrhea. Generally, the prevalence of CT and NG was high. Infection proportions increased among primary partners, particularly women. Etiologic testing without partner tracing and treatment may underestimate burden of CT/NG in this population and contribute to re-infection.
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